Editorial:

Obesity: Mission Possible

James Levine
Diabetes 2007 56: 2653 -2654. [Extract] [Full Text] [PDF]  

Perspectives in Diabetes:

Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular Disease

Marc T. Hamilton, Deborah G. Hamilton, and Theodore W. Zderic
Diabetes 2007 56: 2655 -2667. First published on September 7, 2007 as 10.2337/db07-0882 [Abstract] [Full Text] [PDF]  

Economic Consequences of the Obese

C. Ford Runge
Diabetes 2007 56: 2668 -2672. First published on June 29, 2007 as 10.2337/db07-0633 [Abstract] [Full Text] [PDF]  

Evidence Implicating Eating as a Primary Driver for the Obesity Epidemic

Robert W. Jeffery and Lisa J. Harnack
Diabetes 2007 56: 2673 -2676. First published on September 18, 2007 as 10.2337/db07-1029 [Abstract] [Full Text] [PDF]  

New Methodologies and Databases:

Noninvasive Magnetic Resonance Imaging of Microvascular Changes in Type 1 Diabetes

Zdravka Medarova, Gerardo Castillo, Guangping Dai, Elijah Bolotin, Alexei Bogdanov, and Anna Moore
Diabetes 2007 56: 2677 -2682. First published on August 6, 2007 as 10.2337/db07-0822 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Metabolism:

Effect of Insulin Deprivation on Muscle Mitochondrial ATP Production and Gene Transcript Levels in Type 1 Diabetic Subjects

Helen Karakelides, Yan W. Asmann, Maureen L. Bigelow, Kevin R. Short, Ketan Dhatariya, Jill Coenen-Schimke, Jane Kahl, Debabrata Mukhopadhyay, and K. Sreekumaran Nair
Diabetes 2007 56: 2683 -2689. First published on July 27, 2007 as 10.2337/db07-0378 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Endothelial Nitric Oxide Synthase (eNOS) Knockout Mice Have Defective Mitochondrial ß-Oxidation

Eric Le Gouill, Maria Jimenez, Christophe Binnert, Pierre-Yves Jayet, Sebastien Thalmann, Pascal Nicod, Urs Scherrer, and Peter Vollenweider
Diabetes 2007 56: 2690 -2696. First published on August 6, 2007 as 10.2337/db06-1228 [Abstract] [Full Text] [PDF]  

Inflammation and Endothelial Activation Is Evident at Birth in Offspring of Mothers With Type 1 Diabetes

Scott M. Nelson, Naveed Sattar, Dilys J. Freeman, James D. Walker, and Robert S. Lindsay
Diabetes 2007 56: 2697 -2704. First published on August 17, 2007 as 10.2337/db07-0662 [Abstract] [Full Text] [PDF]  

IGF-1 and Leptin Associate With Fetal HDL Cholesterol at Birth: Examination in Offspring of Mothers With Type 1 Diabetes

Scott M. Nelson, Dilys J. Freeman, Naveed Sattar, Frank D. Johnstone, and Robert S. Lindsay
Diabetes 2007 56: 2705 -2709. First published on July 31, 2007 as 10.2337/db07-0585 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Low Birth Weight and Zygosity Status Is Associated With Defective Muscle Glycogen and Glycogen Synthase Regulation in Elderly Twins

Pernille Poulsen, Jørgen F.P. Wojtaszewski, Erik A. Richter, Henning Beck-Nielsen, and Allan Vaag
Diabetes 2007 56: 2710 -2714. First published on August 13, 2007 as 10.2337/db07-0155 [Abstract] [Full Text] [PDF]  

Signal Transduction:

High Glucose Attenuates Protein S-Nitrosylation in Endothelial Cells: Role of Oxidative Stress

Carol Wadham, Angela Parker, Lijun Wang, and Pu Xia
Diabetes 2007 56: 2715 -2721. First published on August 17, 2007 as 10.2337/db06-1294 [Abstract] [Full Text] [PDF]  

Islet Studies:

Evidence for a Role of Superoxide Generation in Glucose-Induced ß-Cell Dysfunction In Vivo

Christine Tang, Ping Han, Andrei I. Oprescu, Simon C. Lee, Armen V. Gyulkhandanyan, Gary N.Y. Chan, Michael B. Wheeler, and Adria Giacca
Diabetes 2007 56: 2722 -2731. First published on August 6, 2007 as 10.2337/db07-0279 [Abstract] [Full Text] [PDF]  

Protein Kinase C- Activation Markedly Enhances ß-Cell Proliferation: An Essential Role in Growth Factor–Mediated ß-Cell Mitogenesis

Rupangi C. Vasavada, Lin Wang, Yuichi Fujinaka, Karen K. Takane, Taylor C. Rosa, Jose M.D. Mellado-Gil, Peter A. Friedman, and Adolfo Garcia-Ocaña
Diabetes 2007 56: 2732 -2743. First published on August 8, 2007 as 10.2337/db07-0461 [Abstract] [Full Text] [PDF] Online-Only Appendix  

A Switch From Prohormone Convertase (PC)-2 to PC1/3 Expression in Transplanted -Cells Is Accompanied by Differential Processing of Proglucagon and Improved Glucose Homeostasis in Mice

Rhonda D. Wideman, Scott D. Covey, Gene C. Webb, Daniel J. Drucker, and Timothy J. Kieffer
Diabetes 2007 56: 2744 -2752. First published on August 13, 2007 as 10.2337/db07-0563 [Abstract] [Full Text] [PDF]  

Pathophysiology:

Evidence for Vasculoprotective Effects of ET_B Receptors in Resistance Artery Remodeling in Diabetes

Kamakshi Sachidanandam, Vera Portik-Dobos, Alex K. Harris, Jim R. Hutchinson, Erin Muller, Maribeth H. Johnson, and Adviye Ergul
Diabetes 2007 56: 2753 -2758. First published on August 1, 2007 as 10.2337/db07-0426 [Abstract] [Full Text] [PDF]  

Genes Involved in Fatty Acid Partitioning and Binding, Lipolysis, Monocyte/Macrophage Recruitment, and Inflammation Are Overexpressed in the Human Fatty Liver of Insulin-Resistant Subjects

Jukka Westerbacka, Maria Kolak, Tuula Kiviluoto, Perttu Arkkila, Jukka Sirén, Anders Hamsten, Rachel M. Fisher, and Hannele Yki-Järvinen
Diabetes 2007 56: 2759 -2765. First published on August 17, 2007 as 10.2337/db07-0156 [Abstract] [Full Text] [PDF]  

Complications:

Attenuation of Amydgala and Frontal Cortical Responses to Low Blood Glucose Concentration in Asymptomatic Hypoglycemia in Type 1 Diabetes: A New Player in Hypoglycemia Unawareness?

Joel T. Dunn, Iain Cranston, Paul K. Marsden, Stephanie A. Amiel, and Laurence J. Reed
Diabetes 2007 56: 2766 -2773. First published on July 27, 2007 as 10.2337/db07-0666 [Abstract] [Full Text] [PDF]  

Serum Cystatin C Predicts Progression of Subclinical Coronary Atherosclerosis in Individuals With Type 1 Diabetes

David M. Maahs, Lorraine G. Ogden, Adam Kretowski, Janet K. Snell-Bergeon, Gregory L. Kinney, Tomas Berl, and Marian Rewers
Diabetes 2007 56: 2774 -2779. First published on July 27, 2007 as 10.2337/db07-0539 [Abstract] [Full Text] [PDF]  

Decreased L-Type Ca²⁺ Current in Cardiac Myocytes of Type 1 Diabetic Akita Mice Due to Reduced Phosphatidylinositol 3-Kinase Signaling

Zhongju Lu, Ya-Ping Jiang, Xin-Hua Xu, Lisa M. Ballou, Ira S. Cohen, and Richard Z. Lin
Diabetes 2007 56: 2780 -2789. First published on July 31, 2007 as 10.2337/db06-1629 [Abstract] [Full Text] [PDF]  

Evidence of Increased Inflammation and Microcirculatory Abnormalities in Patients With Type 1 Diabetes and Their Role in Microvascular Complications

Sridevi Devaraj, Anthony T. Cheung, Ishwarlal Jialal, Steven C. Griffen, Danh Nguyen, Nicole Glaser, and Thomas Aoki
Diabetes 2007 56: 2790 -2796. First published on August 8, 2007 as 10.2337/db07-0784 [Abstract] [Full Text] [PDF]  

Pharmacology and Therapeutics:

S 26948: a New Specific Peroxisome Proliferator–Activated Receptor Modulator With Potent Antidiabetes and Antiatherogenic Effects

Maria Carmen Carmona, Katie Louche, Bruno Lefebvre, Antoine Pilon, Nathalie Hennuyer, Véronique Audinot-Bouchez, Catherine Fievet, Gérard Torpier, Pierre Formstecher, Pierre Renard, Philippe Lefebvre, Catherine Dacquet, Bart Staels, Louis Casteilla, Luc Pénicaud on behalf of the Consortium of the French Ministry of Research and Technology
Diabetes 2007 56: 2797 -2808. First published on August 17, 2007 as 10.2337/db06-1734 [Abstract] [Full Text] [PDF]  

Abnormal Connexin Expression Underlies Delayed Wound Healing in Diabetic Skin

Chiuhui Mary Wang, Jill Lincoln, Jeremy E. Cook, and David L. Becker
Diabetes 2007 56: 2809 -2817. First published on August 23, 2007 as 10.2337/db07-0613 [Abstract] [Full Text] [PDF]  

Genetics:

Genotype by Diabetes Interaction Effects on the Detection of Linkage of Glomerular Filtration Rate to a Region on Chromosome 2q in Mexican Americans

Sobha Puppala, Rector Arya, Farook Thameem, Nedal H. Arar, Kusum Bhandari, Donna M. Lehman, Jennifer Schneider, Sharon Fowler, Vidya S. Farook, Vincent P. Diego, Laura Almasy, John Blangero, Michael P. Stern, Ravindranath Duggirala, and Hanna E. Abboud
Diabetes 2007 56: 2818 -2828. First published on August 13, 2007 as 10.2337/db06-0984 [Abstract] [Full Text] [PDF]  

Impact of Kir6.2 E23K Polymorphism on the Development of Type 2 Diabetes in a General Japanese Population: The Hisayama Study

Yasufumi Doi, Michiaki Kubo, Toshiharu Ninomiya, Koji Yonemoto, Masanori Iwase, Hisatomi Arima, Jun Hata, Yumihiro Tanizaki, Mitsuo Iida, and Yutaka Kiyohara
Diabetes 2007 56: 2829 -2833. [Abstract] [Full Text] [PDF]  

Frequency of the G/G Genotype of Resistin Single Nucleotide Polymorphism at –420 Appears to Be Increased in Younger-Onset Type 2 Diabetes

Masaaki Ochi, Haruhiko Osawa, Yushi Hirota, Kazuo Hara, Yasuharu Tabara, Yoshiharu Tokuyama, Ikki Shimizu, Azuma Kanatsuka, Yasuhisa Fujii, Jun Ohashi, Tetsuro Miki, Naoto Nakamura, Takashi Kadowaki, Mitsuo Itakura, Masato Kasuga, and Hideichi Makino
Diabetes 2007 56: 2834 -2838. First published on August 13, 2007 as 10.2337/db06-1157 [Abstract] [Full Text] [PDF] Online-Only Appendix  

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