Diabetes -- Table of Contents (December 2007, 56 [12])

Editorial:

Lost in Translation: Facing Up to Translational Research: James Levine
Diabetes 2007 56: 2841 . [Extract] [Full Text] [PDF]

Commentaries:

Genetic Factors in Type 2 Diabetes: All in the (Lipin) Family: Karen Reue and Jimmy Donkor
Diabetes 2007 56: 2842 -2843. [Extract] [Full Text] [PDF]

Genome-Wide Association: Which Do You Want First: the Good News, the Bad News, or the Good News?: Kent D. Taylor, Jill M. Norris, and Jerome I. Rotter
Diabetes 2007 56: 2844 -2848. [Extract] [Full Text] [PDF]

Metabolism:

Short-Term Caloric Restriction Induces Accumulation of Myocardial Triglycerides and Decreases Left Ventricular Diastolic Function in Healthy Subjects: Rutger W. van der Meer, Sebastiaan Hammer, Johannes W.A. Smit, Marijke Frölich, Jeroen J. Bax, Michaela Diamant, Luuk J. Rijzewijk, Albert de Roos, Johannes A. Romijn, and Hildo J. Lamb
Diabetes 2007 56: 2849 -2853. First published on August 23, 2007 as 10.2337/db07-0768 [Abstract] [Full Text] [PDF]

Calmodulin-Binding Domain of AS160 Regulates Contraction- but Not Insulin-Stimulated Glucose Uptake in Skeletal Muscle: Henning F. Kramer, Eric B. Taylor, Carol A. Witczak, Nobuharu Fujii, Michael F. Hirshman, and Laurie J. Goodyear
Diabetes 2007 56: 2854 -2862. First published on August 23, 2007 as 10.2337/db07-0681 [Abstract] [Full Text] [PDF] Online-Only Appendix

Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity: Debby P.Y. Koonen, René L. Jacobs, Maria Febbraio, Martin E. Young, Carrie-Lynn M. Soltys, Huy Ong, Dennis E. Vance, and Jason R.B. Dyck
Diabetes 2007 56: 2863 -2871. First published on August 29, 2007 as 10.2337/db07-0907 [Abstract] [Full Text] [PDF]

Central Insulin Regulates Heart Rate and Arterial Blood Flow: An Endothelial Nitric Oxide Synthase–Dependent Mechanism Altered During Diabetes: Cendrine Cabou, Patrice D. Cani, Gérard Campistron, Claude Knauf, Caroline Mathieu, Claudio Sartori, Jacques Amar, Urs Scherrer, and Rémy Burcelin
Diabetes 2007 56: 2872 -2877. First published on September 5, 2007 as 10.2337/db07-0115 [Abstract] [Full Text] [PDF] Online-Only Appendix

Splanchnic Spillover of Extracellular Lipase–Generated Fatty Acids in Overweight and Obese Humans: Robert H. Nelson, Rita Basu, C. Michael Johnson, Robert A. Rizza, and John M. Miles
Diabetes 2007 56: 2878 -2884. First published on September 19, 2007 as 10.2337/db07-0812 [Abstract] [Full Text] [PDF] Online-Only Appendix

Local Nitric Oxide Synthase Inhibition Reduces Skeletal Muscle Glucose Uptake but Not Capillary Blood Flow During In Situ Muscle Contraction in Rats: Renee M. Ross, Glenn D. Wadley, Michael G. Clark, Stephen Rattigan, and Glenn K. McConell
Diabetes 2007 56: 2885 -2892. First published on September 19, 2007 as 10.2337/db07-0745 [Abstract] [Full Text] [PDF]

Signal Transduction:

Mechanisms of Low-Glucose Sensitivity in Carotid Body Glomus Cells: María García-Fernández, Patricia Ortega-Sáenz, Antonio Castellano, and José López-Barneo
Diabetes 2007 56: 2893 -2900. First published on September 7, 2007 as 10.2337/db07-0122 [Abstract] [Full Text] [PDF]

Loss of TR4 Orphan Nuclear Receptor Reduces Phosphoenolpyruvate Carboxykinase–Mediated Gluconeogenesis: Ning-Chun Liu, Wen-Jye Lin, Eungseok Kim, Loretta L. Collins, Hung-Yun Lin, I-Chen Yu, Janet D. Sparks, Lu-Min Chen, Yi-Fen Lee, and Chawnshang Chang
Diabetes 2007 56: 2901 -2909. First published on September 7, 2007 as 10.2337/db07-0359 [Abstract] [Full Text] [PDF]

Obesity Studies:

Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications: Katherine J. Strissel, Zlatina Stancheva, Hideaki Miyoshi, James W. Perfield, II, Jason DeFuria, Zoe Jick, Andrew S. Greenberg, and Martin S. Obin
Diabetes 2007 56: 2910 -2918. First published on September 11, 2007 as 10.2337/db07-0767 [Abstract] [Full Text] [PDF] Online-Only Appendix

Immunology and Transplantation:

Aberrant Endometrial Features of Pregnancy in Diabetic NOD Mice: Suzanne D. Burke, Hongmei Dong, Aleah D. Hazan, and B. Anne Croy
Diabetes 2007 56: 2919 -2926. First published on September 7, 2007 as 10.2337/db07-0773 [Abstract] [Full Text] [PDF]

Islet Studies:

Free Fatty Acid–Induced Reduction in Glucose-Stimulated Insulin Secretion: Evidence for a Role of Oxidative Stress In Vitro and In Vivo: Andrei I. Oprescu, George Bikopoulos, Anthony Naassan, Emma M. Allister, Christine Tang, Edward Park, Hiroshi Uchino, Gary F. Lewis, I. George Fantus, Maria Rozakis-Adcock, Michael B. Wheeler, and Adria Giacca
Diabetes 2007 56: 2927 -2937. First published on August 23, 2007 as 10.2337/db07-0075 [Abstract] [Full Text] [PDF] Online-Only Appendix

MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse: Francis C. Lynn, Peter Skewes-Cox, Yasuhiro Kosaka, Michael T. McManus, Brian D. Harfe, and Michael S. German
Diabetes 2007 56: 2938 -2945. First published on September 5, 2007 as 10.2337/db07-0175 [Abstract] [Full Text] [PDF] Online-Only Appendix

Stromal Cell–Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic ß-Cell Survival by Activation of the Prosurvival Kinase Akt: Tatsuya Yano, Zhengyu Liu, Jennifer Donovan, Melissa K. Thomas, and Joel F. Habener
Diabetes 2007 56: 2946 -2957. First published on September 18, 2007 as 10.2337/db07-0291 [Abstract] [Full Text] [PDF] Online-Only Appendix

Pathophysiology:

Hyperinsulinemia Rapidly Increases Human Muscle Microvascular Perfusion but Fails to Increase Muscle Insulin Clearance: Evidence That a Saturable Process Mediates Muscle Insulin Uptake: Emma M. Eggleston, Linda A. Jahn, and Eugene J. Barrett
Diabetes 2007 56: 2958 -2963. First published on August 24, 2007 as 10.2337/db07-0670 [Abstract] [Full Text] [PDF]

Childhood Predictors of Young-Onset Type 2 Diabetes: Paul W. Franks, Robert L. Hanson, William C. Knowler, Carol Moffett, Gleebah Enos, Aniello M. Infante, Jonathan Krakoff, and Helen C. Looker
Diabetes 2007 56: 2964 -2972. First published on August 24, 2007 as 10.2337/db06-1639 [Abstract] [Full Text] [PDF] Online-Only Appendix

Essential Role of Mitochondrial Function in Adiponectin Synthesis in Adipocytes: Eun Hee Koh, Joong-Yeol Park, Hye-Sun Park, Min Jae Jeon, Je Won Ryu, Mina Kim, Sun Young Kim, Min-Seon Kim, Seung-Whan Kim, In Sun Park, Jang Hyun Youn, and Ki-Up Lee
Diabetes 2007 56: 2973 -2981. First published on September 7, 2007 as 10.2337/db07-0510 [Abstract] [Full Text] [PDF] Online-Only Appendix

Thrombospondin-1 Is an Endogenous Activator of TGF-ß in Experimental Diabetic Nephropathy In Vivo: Christoph Daniel, Kathrin Schaub, Kerstin Amann, Jack Lawler, and Christian Hugo
Diabetes 2007 56: 2982 -2989. First published on September 18, 2007 as 10.2337/db07-0551 [Abstract] [Full Text] [PDF]

A 20-Year Prospective Study of Childbearing and Incidence of Diabetes in Young Women, Controlling for Glycemia Before Conception: The Coronary Artery Risk Development in Young Adults (CARDIA) Study: Erica P. Gunderson, Cora E. Lewis, Ai-Lin Tsai, Vicky Chiang, Mercedes Carnethon, Charles P. Quesenberry, Jr., and Stephen Sidney
Diabetes 2007 56: 2990 -2996. First published on September 26, 2007 as 10.2337/db07-1024 [Abstract] [Full Text] [PDF]

Complications:

Protective Effects of Cyclooxygenase-2 Gene Inactivation Against Peripheral Nerve Dysfunction and Intraepidermal Nerve Fiber Loss in Experimental Diabetes: Aaron P. Kellogg, Tim D. Wiggin, Dennis D. Larkin, John M. Hayes, Martin J. Stevens, and Rodica Pop-Busui
Diabetes 2007 56: 2997 -3005. First published on August 24, 2007 as 10.2337/db07-0740 [Abstract] [Full Text] [PDF]

Pharmacology and Therapeutics:

Incretin Receptors for Glucagon-Like Peptide 1 and Glucose-Dependent Insulinotropic Polypeptide Are Essential for the Sustained Metabolic Actions of Vildagliptin in Mice: Grace Flock, Laurie L. Baggio, Christine Longuet, and Daniel J. Drucker
Diabetes 2007 56: 3006 -3013. First published on August 23, 2007 as 10.2337/db07-0697 [Abstract] [Full Text] [PDF] Online-Only Appendix

The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Joseph DiChiara, Kevin P. Bliden, Udaya S. Tantry, Miruais S. Hamed, Mark J. Antonino, Thomas A. Suarez, Oscar Bailon, Anand Singla, and Paul A. Gurbel
Diabetes 2007 56: 3014 -3019. First published on September 11, 2007 as 10.2337/db07-0707 [Abstract] [Full Text] [PDF]

Genetics:

LPIN2 Is Associated With Type 2 Diabetes, Glucose Metabolism, and Body Composition: Yurii S. Aulchenko, Jan Pullen, Wigard P. Kloosterman, Mojgan Yazdanpanah, Albert Hofman, Norbert Vaessen, Pieter J.L.M. Snijders, Dmitry Zubakov, Ian Mackay, Mark Olavesen, Balbinder Sidhu, Vicki E. Smith, Alisoun Carey, Eugene Berezikov, André G. Uitterlinden, Ronald H.A. Plasterk, Ben A. Oostra, and Cornelia M. van Duijn
Diabetes 2007 56: 3020 -3026. First published on September 5, 2007 as 10.2337/db07-0338 [Abstract] [Full Text] [PDF] Online-Only Appendix

Variants in the Plasmacytoma Variant Translocation Gene (PVT1) Are Associated With End-Stage Renal Disease Attributed to Type 1 Diabetes: Meredith P. Millis, Danielle Bowen, Christopher Kingsley, Richard M. Watanabe, and Johanna K. Wolford
Diabetes 2007 56: 3027 -3032. First published on September 19, 2007 as 10.2337/db07-0675 [Abstract] [Full Text] [PDF] Online-Only Appendix

Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-Wide Association Studies: M. Geoffrey Hayes, Anna Pluzhnikov, Kazuaki Miyake, Ying Sun, Maggie C.Y. Ng, Cheryl A. Roe, Jennifer E. Below, Raluca I. Nicolae, Anuar Konkashbaev, Graeme I. Bell, Nancy J. Cox, and Craig L. Hanis
Diabetes 2007 56: 3033 -3044. First published on September 10, 2007 as 10.2337/db07-0482 [Abstract] [Full Text] [PDF] Online-Only Appendix

A Search for Variants Associated With Young-Onset Type 2 Diabetes in American Indians in a 100K Genotyping Array: Robert L. Hanson, Clifton Bogardus, David Duggan, Sayuko Kobes, Michele Knowlton, Aniello M. Infante, Leslie Marovich, Deb Benitez, Leslie J. Baier, and William C. Knowler
Diabetes 2007 56: 3045 -3052. First published on September 10, 2007 as 10.2337/db07-0462 [Abstract] [Full Text] [PDF] Online-Only Appendix

Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order Amish: Evidence for Replication From Diabetes-Related Quantitative Traits and From Independent Populations: Evadnie Rampersaud, Coleen M. Damcott, Mao Fu, Haiqing Shen, Patrick McArdle, Xiaolian Shi, John Shelton, Jing Yin, Yen-Pei C. Chang, Sandra H. Ott, Li Zhang, Yiju Zhao, Braxton D. Mitchell, Jeffery O'Connell, and Alan R. Shuldiner
Diabetes 2007 56: 3053 -3062. First published on September 10, 2007 as 10.2337/db07-0457 [Abstract] [Full Text] [PDF] Online-Only Appendix

A 100K Genome-Wide Association Scan for Diabetes and Related Traits in the Framingham Heart Study: Replication and Integration With Other Genome-Wide Datasets: Jose C. Florez, Alisa K. Manning, Josée Dupuis, Jarred McAteer, Kathryn Irenze, Lauren Gianniny, Daniel B. Mirel, Caroline S. Fox, L. Adrienne Cupples, and James B. Meigs
Diabetes 2007 56: 3063 -3074. First published on September 11, 2007 as 10.2337/db07-0451 [Abstract] [Full Text] [PDF] Online-Only Appendix

Interleukin-6 Receptor Gene Variations, Plasma Interleukin-6 Levels, and Type 2 Diabetes in U.S. Women: Lu Qi, Nader Rifai, and Frank B. Hu
Diabetes 2007 56: 3075 -3081. First published on September 26, 2007 as 10.2337/db07-0505 [Abstract] [Full Text] [PDF]

TCF7L2 Is Not a Major Susceptibility Gene for Type 2 Diabetes in Pima Indians: Analysis of 3,501 Individuals: Tingwei Guo, Robert L. Hanson, Michael Traurig, Yunhua Li Muller, Lijun Ma, Janel Mack, Sayuko Kobes, William C. Knowler, Clifton Bogardus, and Leslie J. Baier
Diabetes 2007 56: 3082 -3088. First published on October 1, 2007 as 10.2337/db07-0621 [Abstract] [Full Text] [PDF] Online-Only Appendix

Variants in the Ca_v2.3 ( ${alpha}$ 1E) Subunit of Voltage-Activated Ca²⁺ Channels Are Associated With Insulin Resistance and Type 2 Diabetes in Pima Indians: Yunhua Li Muller, Robert L. Hanson, Collin Zimmerman, Inge Harper, Jeff Sutherland, Sayuko Kobes, the International Type 2 Diabetes 1q Consortium, William C. Knowler, Clifton Bogardus, and Leslie J. Baier
Diabetes 2007 56: 3089 -3094. First published on August 24, 2007 as 10.2337/db07-0587 [Abstract] [Full Text] [PDF] Online-Only Appendix

Effects of Genetic Variation in the Human Retinol Binding Protein-4 Gene (RBP4) on Insulin Resistance and Fat Depot–Specific mRNA Expression: Peter Kovacs, Michaela Geyer, Janin Berndt, Nora Klöting, Timothy E. Graham, Yvonne Böttcher, Beate Enigk, Anke Tönjes, Dorit Schleinitz, Michael R. Schön, Barbara B. Kahn, Matthias Blüher, and Michael Stumvoll
Diabetes 2007 56: 3095 -3100. First published on August 29, 2007 as 10.2337/db06-1647 [Abstract] [Full Text] [PDF] Online-Only Appendix

Common Variants of the Novel Type 2 Diabetes Genes CDKAL1 and HHEX/IDE Are Associated With Decreased Pancreatic ß-Cell Function: Laura Pascoe, Andrea Tura, Sheila K. Patel, Ibrahim M. Ibrahim, Ele Ferrannini, Eleftheria Zeggini, Michael N. Weedon, Andrea Mari, Andrew T. Hattersley, Mark I. McCarthy, Timothy M. Frayling, Mark Walker for the RISC Consortium and the U.K. Type 2 Diabetes Genetics Consortium
Diabetes 2007 56: 3101 -3104. First published on September 5, 2007 as 10.2337/db07-0634 [Abstract] [Full Text] [PDF] Online-Only Appendix

Studies of Association of Variants Near the HHEX, CDKN2A/B, and IGF2BP2 Genes With Type 2 Diabetes and Impaired Insulin Release in 10,705 Danish Subjects: Validation and Extension of Genome-Wide Association Studies: Niels Grarup, Chrisian S. Rose, Ehm A. Andersson, Gitte Andersen, Arne L. Nielsen, Anders Albrechtsen, Jesper O. Clausen, Signe S. Rasmussen, Torben Jørgensen, Annelli Sandbæk, Torsten Lauritzen, Ole Schmitz, Torben Hansen, and Oluf Pedersen
Diabetes 2007 56: 3105 -3111. First published on September 7, 2007 as 10.2337/db07-0856 [Abstract] [Full Text] [PDF] Online-Only Appendix

Studies in 3,523 Norwegians and Meta-Analysis in 11,571 Subjects Indicate That Variants in the Hepatocyte Nuclear Factor 4 ${alpha}$ (HNF4A) P2 Region Are Associated With Type 2 Diabetes in Scandinavians: Stefan Johansson, Helge Ræder, Stig Å Eide, Kristian Midthjell, Kristian Hveem, Oddmund Søvik, Anders Molven, and Pål Rasmus Njølstad
Diabetes 2007 56: 3112 -3117. First published on September 7, 2007 as 10.2337/db07-0513 [Abstract] [Full Text] [PDF] Online-Only Appendix

Online Letters to the Editor:

Comment on: Cani et al. (2007) Metabolic Endotoxemia Initiates Obesity and Insulin Resistance: Diabetes 56:1761–1772: Toshiyuki Saito, Hideaki Hayashida, and Reiko Furugen
Diabetes 2007 56: e20 . [Extract] [Full Text] [PDF]

Response to Comment on: Cani et al. (2007) Metabolic Endotoxemia Initiates Obesity and Insulin Resistance: Diabetes 56:1761–1772: Rémy Burcelin, Patrice D. Cani, and Jacques Amar
Diabetes 2007 56: e21 . [Extract] [Full Text] [PDF]

Comment on: Chang et al. (2007) Association Study of the Genetic Polymorphisms of the Transcription Factor 7-like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population: Diabetes 56:2631–2637: Chee-Seng Ku, Moira Khaw, and Kee Seng Chia
Diabetes 2007 56: e22 . First published on December 1, 2007 as 10.2337/db07-1213 [Extract] [Full Text] [PDF]

Response to Comment on: Chang et al. (2007) Association Study of the Genetic Polymorphisms of the Transcription Factor 7-like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population: Diabetes 56:2631–2637: Yi-Cheng Chang, Ken C. Chiu, and Lee-Ming Chuang
Diabetes 2007 56: e23 . [Extract] [Full Text] [PDF]