Obesity Studies:

Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin

Romain Harmancey, Jean-Michel Senard, Philippe Rouet, Atul Pathak, and Fatima Smih
Diabetes 2007 56: 553 -563. [Abstract] [Full Text] [PDF]  

Diet-Induced Increases in Adiposity, but Not Plasma Lipids, Promote Macrophage Infiltration Into White Adipose Tissue

Kimberly R. Coenen, Marnie L. Gruen, Alan Chait, and Alyssa H. Hasty
Diabetes 2007 56: 564 -573. [Abstract] [Full Text] [PDF]  

Antidiabetic Effects of cis-9, trans-11–Conjugated Linoleic Acid May Be Mediated via Anti-Inflammatory Effects in White Adipose Tissue

Fiona Moloney, Sinead Toomey, Enda Noone, Anne Nugent, Bernard Allan, Christine E. Loscher, and Helen M. Roche
Diabetes 2007 56: 574 -582. [Abstract] [Full Text] [PDF]  

Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism

Mikael Bjursell, Andrea Ahnmark, Mohammad Bohlooly-Y, Lena William-Olsson, Magdalena Rhedin, Xiao-Rong Peng, Karolina Ploj, Anna-Karin Gerdin, Gunnel Arnerup, Anders Elmgren, Anna-Lena Berg, Jan Oscarsson, and Daniel Lindén
Diabetes 2007 56: 583 -593. [Abstract] [Full Text] [PDF]  

Immunology/Transplantation:

Superiority of Small Islets in Human Islet Transplantation

Roger Lehmann, Richard A. Zuellig, Patrick Kugelmeier, Philipp B. Baenninger, Wolfgang Moritz, Aurel Perren, Pierre-Alain Clavien, Markus Weber, and Giatgen A. Spinas
Diabetes 2007 56: 594 -603. [Abstract] [Full Text] [PDF]  

No Alterations in the Frequency of FOXP3⁺ Regulatory T-Cells in Type 1 Diabetes

Todd Brusko, Clive Wasserfall, Kieran McGrail, Richard Schatz, Hilla Lee Viener, Desmond Schatz, Michael Haller, Jennifer Rockell, Peter Gottlieb, Michael Clare-Salzler, and Mark Atkinson
Diabetes 2007 56: 604 -612. [Abstract] [Full Text] [PDF]  

CD8⁺ T-Cell Responses Identify ß-Cell Autoimmunity in Human Type 1 Diabetes

Roberto Mallone, Emanuela Martinuzzi, Philippe Blancou, Giulia Novelli, Georgia Afonso, Manuel Dolz, Graziella Bruno, Lucy Chaillous, Lucienne Chatenoud, Jean-Marie Bach, and Peter van Endert
Diabetes 2007 56: 613 -621. [Abstract] [Full Text] [PDF]  

CCL4 Protects From Type 1 Diabetes by Altering Islet ß-Cell–Targeted Inflammatory Responses

Craig Meagher, Guillermo Arreaza, Andrew Peters, Craig A. Strathdee, Philippe A. Gilbert, Qing-Sheng Mi, Pere Santamaria, Gregory A. Dekaban, and Terry L. Delovitch
Diabetes 2007 56: 809 -817. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Islet Studies:

PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic ß-Cells

Claudia Miele, Gregory Alexander Raciti, Angela Cassese, Chiara Romano, Ferdinando Giacco, Francesco Oriente, Flora Paturzo, Francesco Andreozzi, Assunta Zabatta, Giancarlo Troncone, Fatima Bosch, Anna Pujol, Hervé Chneiweiss, Pietro Formisano, and Francesco Beguinot
Diabetes 2007 56: 622 -633. [Abstract] [Full Text] [PDF]  

Patients With Chronic Pancreatitis Have Islet Progenitor Cells in Their Ducts, but Reversal of Overt Diabetes in NOD Mice by Anti-CD3 Shows No Evidence for Islet Regeneration

Jenny M. Phillips, Lorraine O’Reilly, Chris Bland, Alan K. Foulis, and Anne Cooke
Diabetes 2007 56: 634 -640. [Abstract] [Full Text] [PDF]  

Rapid Turnover of Phosphatidylinositol-4,5-Bisphosphate in Insulin-Secreting Cells Mediated by Ca²⁺ and the ATP-to-ADP Ratio

Sophia Thore, Anne Wuttke, and Anders Tengholm
Diabetes 2007 56: 818 -826. [Abstract] [Full Text] [PDF]  

Glucose Regulation of Insulin Gene Transcription and Pre-mRNA Processing in Human Islets

Carmella Evans-Molina, James C. Garmey, Robert Ketchum, Kenneth L. Brayman, Shaoping Deng, and Raghavendra G. Mirmira
Diabetes 2007 56: 827 -835. [Abstract] [Full Text] [PDF]  

Complications:

Contributions of Inflammation and Cardiac Matrix Metalloproteinase Activity to Cardiac Failure in Diabetic Cardiomyopathy: The Role of Angiotensin Type 1 Receptor Antagonism

Dirk Westermann, Susanne Rutschow, Sebastian Jäger, Anne Linderer, Stefan Anker, Alexander Riad, Thomas Unger, Heinz-Peter Schultheiss, Matthias Pauschinger, and Carsten Tschöpe
Diabetes 2007 56: 641 -646. [Abstract] [Full Text] [PDF]  

Anti-Inflammatory Effects of the Advanced Glycation End Product Inhibitor LR-90 in Human Monocytes

James L. Figarola, Narkunaraja Shanmugam, Rama Natarajan, and Samuel Rahbar
Diabetes 2007 56: 647 -655. [Abstract] [Full Text] [PDF]  

In Mice With Type 2 Diabetes, a Vascular Endothelial Growth Factor (VEGF)-Activating Transcription Factor Modulates VEGF Signaling and Induces Therapeutic Angiogenesis After Hindlimb Ischemia

Yongjun Li, Surovi Hazarika, Donghua Xie, Anne M. Pippen, Christopher D. Kontos, and Brian H. Annex
Diabetes 2007 56: 656 -665. [Abstract] [Full Text] [PDF]  

Endothelial Nitric Oxide Synthase Uncoupling Impairs Endothelial Progenitor Cell Mobilization and Function in Diabetes

Thomas Thum, Daniela Fraccarollo, Maximilian Schultheiss, Sabrina Froese, Paolo Galuppo, Julian D. Widder, Dimitrios Tsikas, Georg Ertl, and Johann Bauersachs
Diabetes 2007 56: 666 -674. [Abstract] [Full Text] [PDF]  

Relationship of Traditional and Nontraditional Cardiovascular Risk Factors to Coronary Artery Calcium in Type 2 Diabetes

Theodore Mazzone, Peter M. Meyer, George T. Kondos, Michael H. Davidson, Steven B. Feinstein, Ralph B. D’Agostino, Sr., Alfonso Perez, and Steven M. Haffner
Diabetes 2007 56: 849 -855. [Abstract] [Full Text] [PDF]  

Genetics:

Investigation of the Estrogen Receptor- Gene With Type 2 Diabetes and/or Nephropathy in African-American and European-American Populations

Carla J. Gallagher, Keith L. Keene, Josyf C. Mychaleckyj, Carl D. Langefeld, Joel N. Hirschhorn, Brian E. Henderson, Candace J. Gordon, Barry I. Freedman, Stephen S. Rich, Donald W. Bowden, and Michèle M. Sale
Diabetes 2007 56: 675 -684. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

Wendy Winckler, Michael N. Weedon, Robert R. Graham, Steven A. McCarroll, Shaun Purcell, Peter Almgren, Tiinamaija Tuomi, Daniel Gaudet, Kristina Bengtsson Boström, Mark Walker, Graham Hitman, Andrew T. Hattersley, Mark I. McCarthy, Kristin G. Ardlie, Joel N. Hirschhorn, Mark J. Daly, Timothy M. Frayling, Leif Groop, and David Altshuler
Diabetes 2007 56: 685 -693. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Activating Transcription Factor 6 (ATF6) Sequence Polymorphisms in Type 2 Diabetes and Pre-Diabetic Traits

Winston S. Chu, Swapan Kumar Das, Hua Wang, Juliana C. Chan, Panos Deloukas, Philippe Froguel, Leslie J. Baier, Weiping Jia, Mark I. McCarthy, Maggie C.Y. Ng, Coleen Damcott, Alan R. Shuldiner, Eleftheria Zeggini, and Steven C. Elbein
Diabetes 2007 56: 856 -862. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Polymorphisms of the Renin-Angiotensin System Genes Predict Progression of Subclinical Coronary Atherosclerosis

Adam Kretowski, Kim McFann, John E. Hokanson, David Maahs, Gregory Kinney, Janet K. Snell-Bergeon, R. Paul Wadwa, Robert H. Eckel, Lorraine Ogden, Satish Garg, Jia Li, Suzanne Cheng, Henry A. Erlich, and Marian Rewers
Diabetes 2007 56: 863 -871. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Genetic Variation, C-Reactive Protein Levels, and Incidence of Diabetes

Abbas Dehghan, Isabella Kardys, Moniek P.M. de Maat, Andre G. Uitterlinden, Eric J.G. Sijbrands, Aart H. Bootsma, Theo Stijnen, Albert Hofman, Miranda T. Schram, and Jacqueline C.M. Witteman
Diabetes 2007 56: 872 -878. [Abstract] [Full Text] [PDF]  

Brief Reports:

Common Variation in LMNA Increases Susceptibility to Type 2 Diabetes and Associates With Elevated Fasting Glycemia and Estimates of Body Fat and Height in the General Population: Studies of 7,495 Danish Whites

Lise Wegner, Gitte Andersen, Thomas Sparsø, Niels Grarup, Charlotte Glümer, Knut Borch-Johnsen, Torben Jørgensen, Torben Hansen, and Oluf Pedersen
Diabetes 2007 56: 694 -698. [Abstract] [Full Text] [PDF] Online-Only Appendix  

No Evidence for Mouse Pancreatic ß-Cell Epithelial-Mesenchymal Transition In Vitro

Fouad Atouf, Cheol Hong Park, Klaus Pechhold, Malancha Ta, Yong Choi, and Nadya L. Lumelsky
Diabetes 2007 56: 699 -702. [Abstract] [Full Text] [PDF]  

Limited Capacity of Human Adult Islets Expanded In Vitro to Redifferentiate Into Insulin-Producing ß-Cells

Ayse G. Kayali, Luis E. Flores, Ana D. Lopez, Burak Kutlu, Emmanuel Baetge, Ryuichi Kitamura, Ergeng Hao, Gillian M. Beattie, and Alberto Hayek
Diabetes 2007 56: 703 -708. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene With Diabetes

Luc Marchand and Constantin Polychronakos
Diabetes 2007 56: 709 -713. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Analysis of Genetic Variation in Akt2/PKB-ß in Severe Insulin Resistance, Lipodystrophy, Type 2 Diabetes, and Related Metabolic Phenotypes

Karen Tan, Wendy A. Kimber, Jian’an Luan, Maria A. Soos, Robert K. Semple, Nicholas J. Wareham, Stephen O’Rahilly, and Inês Barroso
Diabetes 2007 56: 714 -719. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Common Variation in the LMNA Gene (Encoding Lamin A/C) and Type 2 Diabetes: Association Analyses in 9,518 Subjects

Katharine R. Owen, Christopher J. Groves, Robert L. Hanson, William C. Knowler, Alan R. Shuldiner, Steven C. Elbein, Braxton D. Mitchell, Philippe Froguel, Maggie C.Y. Ng, Juliana C. Chan, Weiping Jia, Panos Deloukas, Graham A. Hitman, Mark Walker, Timothy M. Frayling, Andrew T. Hattersley, Eleftheria Zeggini, Mark I. McCarthy for the International Type 2 Diabetes 1q Consortium
Diabetes 2007 56: 879 -883. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Lamin A/C Polymorphisms, Type 2 Diabetes, and the Metabolic Syndrome: Case-Control and Quantitative Trait Studies

José L. Mesa, Ruth J.F. Loos, Paul W. Franks, Ken K. Ong, Jian’an Luan, Stephen O’Rahilly, Nicholas J. Wareham, and Inês Barroso
Diabetes 2007 56: 884 -889. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Meta-Analysis of Genome-Wide Linkage Studies of Quantitative Lipid Traits in Families Ascertained for Type 2 Diabetes

Alka Malhotra, Steven C. Elbein, Maggie C.Y. Ng, Ravindranath Duggirala, Rector Arya, Giuseppina Imperatore, Adebowale Adeyemo, Toni I. Pollin, Wen-Chi Hsueh, Juliana C.N. Chan, Charles Rotimi, Robert L. Hanson, Sandra J. Hasstedt, Johanna K. Wolford, and and the American Diabetes Association GENNID Study Group
Diabetes 2007 56: 890 -896. [Abstract] [Full Text] [PDF]  

Metabolism:

Family History of Diabetes Links Impaired Substrate Switching and Reduced Mitochondrial Content in Skeletal Muscle

Barbara Ukropcova, Olga Sereda, Lilian de Jonge, Iwona Bogacka, Tuong Nguyen, Hui Xie, George A. Bray, and Steven R. Smith
Diabetes 2007 56: 720 -727. [Abstract] [Full Text] [PDF]  

Endothelin Limits Insulin Action in Obese/Insulin-Resistant Humans

Amale Lteif, Prashant Vaishnava, Alain D. Baron, and Kieren J. Mather
Diabetes 2007 56: 728 -734. [Abstract] [Full Text] [PDF]  

Increases in Adiponectin Predict Improved Liver, but Not Peripheral, Insulin Sensitivity in Severely Obese Women During Weight Loss

Edward Lin, Lawrence S. Phillips, Thomas R. Ziegler, Brian Schmotzer, Kongjun Wu, Li H. Gu, Leena Khaitan, Scott A. Lynch, William E. Torres, C. Daniel Smith, and Nana Gletsu-Miller
Diabetes 2007 56: 735 -742. [Abstract] [Full Text] [PDF]  

Paradoxical Changes in Muscle Gene Expression in Insulin-Resistant Subjects After Sustained Reduction in Plasma Free Fatty Acid Concentration

Mandeep Bajaj, Rafael Medina-Navarro, Swangjit Suraamornkul, Christian Meyer, Ralph A. DeFronzo, and Lawrence J. Mandarino
Diabetes 2007 56: 743 -752. [Abstract] [Full Text] [PDF]  

Two Years of Treatment With Dehydroepiandrosterone Does Not Improve Insulin Secretion, Insulin Action, or Postprandial Glucose Turnover in Elderly Men or Women

Rita Basu, Chiara Dalla Man, Marco Campioni, Ananda Basu, K. Sree Nair, Michael D. Jensen, Sundeep Khosla, George Klee, Gianna Toffolo, Claudio Cobelli, and Robert A. Rizza
Diabetes 2007 56: 753 -766. [Abstract] [Full Text] [PDF]  

The Small Polyphenolic Molecule Kaempferol Increases Cellular Energy Expenditure and Thyroid Hormone Activation

Wagner S. da-Silva, John W. Harney, Brian W. Kim, Jing Li, Suzy D.C. Bianco, Alessandra Crescenzi, Marcelo A. Christoffolete, Stephen A. Huang, and Antonio C. Bianco
Diabetes 2007 56: 767 -776. [Abstract] [Full Text] [PDF] Online-Only Appendix  

Role of Excess Glycogenolysis in Fasting Hyperglycemia Among Pre-Diabetic and Diabetic Zucker (fa/fa) Rats

Eunsook S. Jin, Byung-Hyun Park, A. Dean Sherry, and Craig R. Malloy
Diabetes 2007 56: 777 -785. [Abstract] [Full Text] [PDF]  

Signal Transduction:

AMP-Activated Protein Kinase 2 Deficiency Affects Cardiac Cardiolipin Homeostasis and Mitochondrial Function

Yoni Athéa, Benoît Viollet, Philippe Mateo, Delphine Rousseau, Marta Novotova, Anne Garnier, Sophie Vaulont, James R. Wilding, Alain Grynberg, Vladimir Veksler, Jacqueline Hoerter, and Renée Ventura-Clapier
Diabetes 2007 56: 786 -794. [Abstract] [Full Text] [PDF]  

Effects of Pioglitazone on Suppressor of Cytokine Signaling 3 Expression: Potential Mechanisms for Its Effects on Insulin Sensitivity and Adiponectin Expression

Yukiko Kanatani, Isao Usui, Ken Ishizuka, Agussalim Bukhari, Shiho Fujisaka, Masaharu Urakaze, Tetsuro Haruta, Tadamitsu Kishimoto, Tetsuji Naka, and Masashi Kobayashi
Diabetes 2007 56: 795 -803. [Abstract] [Full Text] [PDF]  

Globular Adiponectin Activates Nuclear Factor-B and Activating Protein-1 and Enhances Angiotensin II–Induced Proliferation in Cardiac Fibroblasts

Yoshiyuki Hattori, Sachiko Hattori, Kazumi Akimoto, Toshio Nishikimi, Kunihiro Suzuki, Hiroaki Matsuoka, and Kikuo Kasai
Diabetes 2007 56: 804 -808. [Abstract] [Full Text] [PDF]  

Pathophysiology:

Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects With Type 2 Diabetes: A Time-Course and Dose-Response Study

Apiradee Sriwijitkamol, Dawn K. Coletta, Estela Wajcberg, Gabriela B. Balbontin, Sara M. Reyna, John Barrientes, Phyllis A. Eagan, Christopher P. Jenkinson, Eugenio Cersosimo, Ralph A. DeFronzo, Kei Sakamoto, and Nicolas Musi
Diabetes 2007 56: 836 -848. [Abstract] [Full Text] [PDF]  

Errata:

Errata

Diabetes 2007 56: 897 . [Extract] [Full Text] [PDF]  

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