Diabetes -- Table of Contents (April 2007, 56 [4])

Obesity Studies:

Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation: Naomi Hosogai, Atsunori Fukuhara, Kazuya Oshima, Yugo Miyata, Sachiyo Tanaka, Katsumori Segawa, Shigetada Furukawa, Yoshihiro Tochino, Ryutaro Komuro, Morihiro Matsuda, and Iichiro Shimomura
Diabetes 2007 56: 901 -911. [Abstract] [Full Text] [PDF]

Uncoupling Protein-2 Controls Adiponectin Gene Expression in Adipose Tissue Through the Modulation of Reactive Oxygen Species Production: Emmanuel Chevillotte, Marta Giralt, Bruno Miroux, Daniel Ricquier, and Francesc Villarroya
Diabetes 2007 56: 1042 -1050. [Abstract] [Full Text] [PDF]

Estradiol-Dependent Decrease in the Orexigenic Potency of Ghrelin in Female Rats: Deborah J. Clegg, Lynda M. Brown, Jeffrey M. Zigman, Christopher J. Kemp, April D. Strader, Stephen C. Benoit, Stephen C. Woods, Michela Mangiaracina, and Nori Geary
Diabetes 2007 56: 1051 -1058. First published on January 24, 2007 as 10.2337/db06-0015 [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Characterization of Donor Dendritic Cells and Enhancement of Dendritic Cell Efflux With cc-Chemokine Ligand 21: A Novel Strategy to Prolong Islet Allograft Survival: Paolo Fiorina, Mollie Jurewicz, Katsunori Tanaka, Negin Behazin, Andrea Augello, Andrea Vergani, Uli Von Adrian, Neal R. Smith, Mohamed H. Sayegh, and Reza Abdi
Diabetes 2007 56: 912 -920. First published on February 7, 2007 as 10.2337/db06-1445 [Abstract] [Full Text] [PDF] Online-Only Appendix

Minimal Impact of a De Novo–Expressed ß-Cell Autoantigen on Spontaneous Diabetes Development in NOD Mice: Marianne M. Martinic, Amy E. Juedes, Damien Bresson, Dirk Homann, Kresten Skak, Christoph Huber, Eleanor Ling, Mette Ejrnaes, Tom Wolfe, Lisa Togher, Urs Christen, and Matthias G. von Herrath
Diabetes 2007 56: 1059 -1068. [Abstract] [Full Text] [PDF]

Islet Studies:

Insulin-Expressing Colonies Developed From Murine Embryonic Stem Cell–Derived Progenitors: Hsun Teresa Ku, Jing Chai, Yoon-Jung Kim, Peter White, Sheetal Purohit-Ghelani, Klaus H. Kaestner, and Jonathan S. Bromberg
Diabetes 2007 56: 921 -929. [Abstract] [Full Text] [PDF] Online-Only Appendix

Ubiquitinated-Protein Aggregates Form in Pancreatic ß-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy: Natalia A. Kaniuk, Michael Kiraly, Holly Bates, Mladen Vranic, Allen Volchuk, and John H. Brumell
Diabetes 2007 56: 930 -939. [Abstract] [Full Text] [PDF]

Phenotype and Functional Characteristics of Islet-Infiltrating B-Cells Suggest the Existence of Immune Regulatory Mechanisms in Islet Milieu: Maria Carmen Puertas, Jorge Carrillo, Xavier Pastor, Rosa Maria Ampudia, Aurora Alba, Raquel Planas, Ricardo Pujol-Borrell, Marta Vives-Pi, and Joan Verdaguer
Diabetes 2007 56: 940 -949. [Abstract] [Full Text] [PDF]

Novel Function of the Ciliogenic Transcription Factor RFX3 in Development of the Endocrine Pancreas: Aouatef Ait-Lounis, Dominique Baas, Emmanuèle Barras, Carine Benadiba, Anne Charollais, Rachel Nlend Nlend, Delphine Liègeois, Paolo Meda, Bénédicte Durand, and Walter Reith
Diabetes 2007 56: 950 -959. First published on January 17, 2007 as 10.2337/db06-1187 [Abstract] [Full Text] [PDF] Online-Only Appendix

Transcriptional Regulation of the Endoplasmic Reticulum Stress Gene Chop in Pancreatic Insulin-Producing Cells: Pierre Pirot, Fernanda Ortis, Miriam Cnop, Yanjun Ma, Linda M. Hendershot, Décio L. Eizirik, and Alessandra K. Cardozo
Diabetes 2007 56: 1069 -1077. [Abstract] [Full Text] [PDF] Online-Only Appendix

Cx36-Mediated Coupling Reduces ß-Cell Heterogeneity, Confines the Stimulating Glucose Concentration Range, and Affects Insulin Release Kinetics: Stephan Speier, Asllan Gjinovci, Anne Charollais, Paolo Meda, and Marjan Rupnik
Diabetes 2007 56: 1078 -1086. [Abstract] [Full Text] [PDF]

GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo: Martin G. Latour, Thierry Alquier, Elizabeth Oseid, Caroline Tremblay, Thomas L. Jetton, Jian Luo, Daniel C.-H. Lin, and Vincent Poitout
Diabetes 2007 56: 1087 -1094. [Abstract] [Full Text] [PDF]

Effects of Diazoxide on Gene Expression in Rat Pancreatic Islets Are Largely Linked to Elevated Glucose and Potentially Serve to Enhance ß-Cell Sensitivity: Zuheng Ma, Neil Portwood, David Brodin, Valdemar Grill, and Anneli Björklund
Diabetes 2007 56: 1095 -1106. First published on January 17, 2007 as 10.2337/db06-0322 [Abstract] [Full Text] [PDF]

Zinc, Not Insulin, Regulates the Rat ${alpha}$ -Cell Response to Hypoglycemia In Vivo: Huarong Zhou, Tao Zhang, Jamie S. Harmon, Joseph Bryan, and R. Paul Robertson
Diabetes 2007 56: 1107 -1112. First published on February 22, 2007 as 10.2337/db06-1454 [Abstract] [Full Text] [PDF]

Complications:

Ischemic Vascular Damage Can Be Repaired by Healthy, but Not Diabetic, Endothelial Progenitor Cells: Sergio Caballero, Nilanjana Sengupta, Aqeela Afzal, Kyung-Hee Chang, Sergio Li Calzi, Dennis L. Guberski, Timothy S. Kern, and Maria B. Grant
Diabetes 2007 56: 960 -967. [Abstract] [Full Text] [PDF]

Nephrin Is Critical for the Action of Insulin on Human Glomerular Podocytes: Richard J.M. Coward, Gavin I. Welsh, Ania Koziell, Sagair Hussain, Rachel Lennon, Lan Ni, Jeremy M. Tavaré, Peter W. Mathieson, and Moin A. Saleem
Diabetes 2007 56: 1127 -1135. [Abstract] [Full Text] [PDF]

Effects of Palmitate on Ca²⁺ Handling in Adult Control and ob/ob Cardiomyocytes: Impact of Mitochondrial Reactive Oxygen Species: Jérémy Fauconnier, Daniel C. Andersson, Shi-Jin Zhang, Johanna T. Lanner, Rolf Wibom, Abram Katz, Joseph D. Bruton, and Håkan Westerblad
Diabetes 2007 56: 1136 -1142. First published on January 17, 2007 as 10.2337/db06-0739 [Abstract] [Full Text] [PDF]

Rosiglitazone Inhibits Acyl-CoA Synthetase Activity and Fatty Acid Partitioning to Diacylglycerol and Triacylglycerol via a Peroxisome Proliferator–Activated Receptor- ${gamma}$ –Independent Mechanism in Human Arterial Smooth Muscle Cells and Macrophages: Bardia Askari, Jenny E. Kanter, Ashley M. Sherrid, Deidre L. Golej, Andrew T. Bender, Joey Liu, Willa A. Hsueh, Joseph A. Beavo, Rosalind A. Coleman, and Karin E. Bornfeldt
Diabetes 2007 56: 1143 -1152. First published on January 26, 2007 as 10.2337/db06-0267 [Abstract] [Full Text] [PDF] Figures

Pharmacology and Therapeutics:

Renal Effects of S18886 (Terutroban), a TP Receptor Antagonist, in an Experimental Model of Type 2 Diabetes: Katarína Sebeková, Timo Eifert, André Klassen, August Heidland, and Kerstin Amann
Diabetes 2007 56: 968 -974. First published on January 31, 2007 as 10.2337/db06-1136 [Abstract] [Full Text] [PDF]

Factors Associated With Diabetes Onset During Metformin Versus Placebo Therapy in the Diabetes Prevention Program: John M. Lachin, Costas A. Christophi, Sharon L. Edelstein, David A. Ehrmann, Richard F. Hamman, Steven E. Kahn, William C. Knowler, David M. Nathan on behalf of the DPP Research Group
Diabetes 2007 56: 1153 -1159. [Abstract] [Full Text] [PDF]

Genetics:

Identification of PVT1 as a Candidate Gene for End-Stage Renal Disease in Type 2 Diabetes Using a Pooling-Based Genome-Wide Single Nucleotide Polymorphism Association Study: Robert L. Hanson, David W. Craig, Meredith P. Millis, Kimberly A. Yeatts, Sayuko Kobes, John V. Pearson, Anne M. Lee, William C. Knowler, Robert G. Nelson, and Johanna K. Wolford
Diabetes 2007 56: 975 -983. [Abstract] [Full Text] [PDF]

Genome-Wide Linkage Analyses to Identify Loci for Diabetic Retinopathy: Helen C. Looker, Robert G. Nelson, Emily Chew, Ronald Klein, Barbara E.K. Klein, William C. Knowler, and Robert L. Hanson
Diabetes 2007 56: 1160 -1166. [Abstract] [Full Text] [PDF]

A Genome-Wide Linkage Scan for Diabetic Retinopathy Susceptibility Genes in Mexican Americans With Type 2 Diabetes From Starr County, Texas: D. Michael Hallman, Eric Boerwinkle, Victor H. Gonzalez, Barbara E. K. Klein, Ronald Klein, and Craig L. Hanis
Diabetes 2007 56: 1167 -1173. First published on January 24, 2007 as 10.2337/db06-1373 [Abstract] [Full Text] [PDF] Online-Only Appendix

Metabolism:

Serial Metabolic Measurements and Conversion to Type 2 Diabetes in the West of Scotland Coronary Prevention Study: Specific Elevations in Alanine Aminotransferase and Triglycerides Suggest Hepatic Fat Accumulation as a Potential Contributing Factor: Naveed Sattar, Alex McConnachie, Ian Ford, Allan Gaw, Stephen J. Cleland, Nita G. Forouhi, Peter McFarlane, James Shepherd, Stuart Cobbe, and Chris Packard
Diabetes 2007 56: 984 -991. [Abstract] [Full Text] [PDF]

Acute Hyperglycemia Induces a Global Downregulation of Gene Expression in Adipose Tissue and Skeletal Muscle of Healthy Subjects: Emmanuelle Meugnier, May Faraj, Sophie Rome, Geneviève Beauregard, Angélique Michaut, Véronique Pelloux, Jean-Louis Chiasson, Martine Laville, Karine Clement, Hubert Vidal, and Rémi Rabasa-Lhoret
Diabetes 2007 56: 992 -999. First published on February 15, 2007 as 10.2337/db06-1242 [Abstract] [Full Text] [PDF] Supplementary Tables

Restoration of Glucokinase Expression in the Liver Normalizes Postprandial Glucose Disposal in Mice With Hepatic Deficiency of PDK1: Yasuo Okamoto, Wataru Ogawa, Akihiko Nishizawa, Hiroshi Inoue, Kiyoshi Teshigawara, Shinichi Kinoshita, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Hiroshi Sakaue, Tetsuo Noda, and Masato Kasuga
Diabetes 2007 56: 1000 -1009. First published on January 31, 2007 as 10.2337/db06-1322 [Abstract] [Full Text] [PDF]

Visceral Fat Adipokine Secretion Is Associated With Systemic Inflammation in Obese Humans: Luigi Fontana, J. Christopher Eagon, Maria E. Trujillo, Philipp E. Scherer, and Samuel Klein
Diabetes 2007 56: 1010 -1013. First published on February 7, 2007 as 10.2337/db06-1656 [Abstract] [Full Text] [PDF]

Signal Transduction:

Defective Insulin and Acetylcholine Induction of Endothelial Cell–Nitric Oxide Synthase Through Insulin Receptor Substrate/Akt Signaling Pathway in Aorta of Obese Rats: Henrique G. Zecchin, Fernanda B.M. Priviero, Claudio T. Souza, Karina G. Zecchin, Patrícia O. Prada, José B.C. Carvalheira, Licio A. Velloso, Edson Antunes, and Mario J.A. Saad
Diabetes 2007 56: 1014 -1024. First published on January 17, 2007 as 10.2337/db05-1147 [Abstract] [Full Text] [PDF]

Chronic Treatment With Sildenafil Improves Energy Balance and Insulin Action in High Fat–Fed Conscious Mice: Julio E. Ayala, Deanna P. Bracy, Brianna M. Julien, Jeffrey N. Rottman, Patrick T. Fueger, and David H. Wasserman
Diabetes 2007 56: 1025 -1033. First published on January 17, 2007 as 10.2337/db06-0883 [Abstract] [Full Text] [PDF] Figures

n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor- ${alpha}$ –Dependent Manner: Susanne Neschen, Katsutaro Morino, Jianying Dong, Yanlin Wang-Fischer, Gary W. Cline, Anthony J. Romanelli, Jörg C. Rossbacher, Irene K. Moore, Werner Regittnig, David S. Munoz, Jung H. Kim, and Gerald I. Shulman
Diabetes 2007 56: 1034 -1041. First published on January 24, 2007 as 10.2337/db06-1206 [Abstract] [Full Text] [PDF] Figures

Pathophysiology:

Effects of Nonglucose Nutrients on Insulin Secretion and Action in People With Pre-Diabetes: Gerlies Bock, Chiara Dalla Man, Marco Campioni, Elizabeth Chittilapilly, Rita Basu, Gianna Toffolo, Claudio Cobelli, and Robert Rizza
Diabetes 2007 56: 1113 -1119. [Abstract] [Full Text] [PDF]

ATP-Sensitive K⁺ Channels Regulate the Release of GABA in the Ventromedial Hypothalamus During Hypoglycemia: Owen Chan, Marcus Lawson, Wanling Zhu, Joseph Lee Beverly, and Robert S. Sherwin
Diabetes 2007 56: 1120 -1126. First published on January 24, 2007 as 10.2337/db06-1102 [Abstract] [Full Text] [PDF]

Brief Reports:

Toward Further Mapping of the Association Between the IL2RA Locus and Type 1 Diabetes: Hui-Qi Qu, Alexander Montpetit, Bing Ge, Thomas J. Hudson, and Constantin Polychronakos
Diabetes 2007 56: 1174 -1176. [Abstract] [Full Text] [PDF]

SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes: Hsing-Yi Lin, Chiao-Ling Wang, Pi-Jung Hsiao, Yung-Chuan Lu, Su-Yu Chen, Kun-Der Lin, Shih-Chie Hsin, Ming-Chia Hsieh, and Shyi-Jang Shin
Diabetes 2007 56: 1177 -1180. First published on January 17, 2007 as 10.2337/db06-1283 [Abstract] [Full Text] [PDF]

Single Nucleotide Polymorphisms of the Peroxisome Proliferator–Activated Receptor- ${alpha}$ Gene (PPARA) Influence the Conversion From Impaired Glucose Tolerance to Type 2 Diabetes: The STOP-NIDDM Trial: Laura Andrulionyte, Teemu Kuulasmaa, Jean-Louis Chiasson, Markku Laakso for the STOP-NIDDM Study Group
Diabetes 2007 56: 1181 -1186. First published on February 22, 2007 as 10.2337/db06-1110 [Abstract] [Full Text] [PDF]