Banting Lecture 2006:

Orchestration of Glucose Homeostasis: From a Small Acorn to the California Oak

Richard N. Bergman
Diabetes 2007 56: 1489 -1501. [Extract] [Full Text] [PDF] Online-Only Appendix  

Perspectives in Diabetes:

(How) Can We Prevent Type 2 Diabetes?

Thomas A. Buchanan
Diabetes 2007 56: 1502 -1507. First published on March 27, 2007 as 10.2337/db07-0140 [Extract] [Full Text] [PDF]  

Signal Transduction:

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

Zhengping Yi, Paul Langlais, Elena A. De Filippis, Moulun Luo, Charles R. Flynn, Stefanie Schroeder, Susan T. Weintraub, Rebekka Mapes, and Lawrence J. Mandarino
Diabetes 2007 56: 1508 -1516. First published on March 14, 2007 as 10.2337/db06-1355 [Abstract] [Full Text] [PDF] Online Only Appendix  

The STAT5A-Mediated Induction of Pyruvate Dehydrogenase Kinase 4 Expression by Prolactin or Growth Hormone in Adipocytes

Ursula A. White, Ann A. Coulter, Tiffany K. Miles, and Jacqueline M. Stephens
Diabetes 2007 56: 1623 -1629. First published on March 14, 2007 as 10.2337/db06-1286 [Abstract] [Full Text] [PDF]  

Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle

Stephan Glund, Atul Deshmukh, Yun Chau Long, Theodore Moller, Heikki A. Koistinen, Kenneth Caidahl, Juleen R. Zierath, and Anna Krook
Diabetes 2007 56: 1630 -1637. First published on March 15, 2007 as 10.2337/db06-1733 [Abstract] [Full Text] [PDF]  

Growth Hormone Regulation of p85 Expression and Phosphoinositide 3-Kinase Activity in Adipose Tissue: Mechanism for Growth Hormone–Mediated Insulin Resistance

Juan-Pablo del Rincon, Keiji Iida, Bruce D. Gaylinn, Carrie E. McCurdy, J. Wayne Leitner, Linda A. Barbour, John J. Kopchick, Jacob E. Friedman, Boris Draznin, and Michael O. Thorner
Diabetes 2007 56: 1638 -1646. First published on March 15, 2007 as 10.2337/db06-0299 [Abstract] [Full Text] [PDF]  

Obesity Studies:

Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels

Satoshi Nishimura, Ichiro Manabe, Mika Nagasaki, Yumiko Hosoya, Hiroshi Yamashita, Hideo Fujita, Mitsuru Ohsugi, Kazuyuki Tobe, Takashi Kadowaki, Ryozo Nagai, and Seiryo Sugiura
Diabetes 2007 56: 1517 -1526. First published on March 27, 2007 as 10.2337/db06-1749 [Abstract] [Full Text] [PDF] Online-Only AppendixOnline-Only Appendix  

Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms

Yiying Zhang, Kaiying Guo, Robert E. LeBlanc, Daniella Loh, Gary J. Schwartz, and Yi-Hao Yu
Diabetes 2007 56: 1647 -1654. First published on March 14, 2007 as 10.2337/db07-0123 [Abstract] [Full Text] [PDF]  

Omentin Plasma Levels and Gene Expression Are Decreased in Obesity

Celia M. de Souza Batista, Rong-Ze Yang, Mi-Jeong Lee, Nicole M. Glynn, Dao-Zhan Yu, Jessica Pray, Kelechi Ndubuizu, Susheel Patil, Alan Schwartz, Mark Kligman, Susan K. Fried, Da-Wei Gong, Alan R. Shuldiner, Toni I. Pollin, and John C. McLenithan
Diabetes 2007 56: 1655 -1661. First published on February 28, 2007 as 10.2337/db06-1506 [Abstract] [Full Text] [PDF]  

PPAR Agonists Suppress Osteopontin Expression in Macrophages and Decrease Plasma Levels in Patients With Type 2 Diabetes

Takafumi Nakamachi, Takashi Nomiyama, Florence Gizard, Elizabeth B. Heywood, Karrie L. Jones, Yue Zhao, Lucia Fuentes, Kohzo Takebayashi, Yoshimasa Aso, Bart Staels, Toshihiko Inukai, and Dennis Bruemmer
Diabetes 2007 56: 1662 -1670. First published on March 14, 2007 as 10.2337/db06-1177 [Abstract] [Full Text] [PDF]  

Glucagon-Like Peptide-1 Gene Therapy in Obese Diabetic Mice Results in Long-Term Cure of Diabetes by Improving Insulin Sensitivity and Reducing Hepatic Gluconeogenesis

Young-Sun Lee, Seungjin Shin, Toshikatsu Shigihara, Eunsil Hahm, Meng-Ju Liu, Jaeseok Han, Ji-Won Yoon, and Hee-Sook Jun
Diabetes 2007 56: 1671 -1679. First published on March 16, 2007 as 10.2337/db06-1182 [Abstract] [Full Text] [PDF]  

Body Size and Shape Changes and the Risk of Diabetes in the Diabetes Prevention Program

Wilfred Y. Fujimoto, Kathleen A. Jablonski, George A. Bray, Andrea Kriska, Elizabeth Barrett-Connor, Steven Haffner, Robert Hanson, James O. Hill, Van Hubbard, E. Stamm, F. Xavier Pi-Sunyer for the Diabetes Prevention Program Research Group
Diabetes 2007 56: 1680 -1685. First published on March 15, 2007 as 10.2337/db07-0009 [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

GAD Autoantibody Affinity and Epitope Specificity Identify Distinct Immunization Profiles in Children at Risk for Type 1 Diabetes

Anja Mayr, Michael Schlosser, Natalie Grober, Heidrun Kenk, Anette G. Ziegler, Ezio Bonifacio, and Peter Achenbach
Diabetes 2007 56: 1527 -1533. First published on February 26, 2007 as 10.2337/db06-1715 [Abstract] [Full Text] [PDF]  

Transient Upregulation of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Human Chorionic Gonadotropin Downregulates Autoimmune Diabetes

Aito Ueno, Suzanne Cho, Lu Cheng, Jianxiong Wang, Sheng Hou, Hiroko Nakano, Pere Santamaria, and Yang Yang
Diabetes 2007 56: 1686 -1693. First published on March 14, 2007 as 10.2337/db06-1727 [Abstract] [Full Text] [PDF]  

Islet Studies:

Chronic Activation of Liver X Receptor Induces ß-Cell Apoptosis Through Hyperactivation of Lipogenesis: Liver X Receptor–Mediated Lipotoxicity in Pancreatic ß-Cells

Sung Sik Choe, A Hyun Choi, Joo-Won Lee, Kang Ho Kim, Jun-Jae Chung, Jiyoung Park, Kyeong-Min Lee, Keun-Gyu Park, In-Kyu Lee, and Jae Bum Kim
Diabetes 2007 56: 1534 -1543. First published on March 16, 2007 as 10.2337/db06-1059 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Implantation Site–Dependent Dysfunction of Transplanted Pancreatic Islets

Joey Lau, Göran Mattsson, Carina Carlsson, Daniel Nyqvist, Martin Köhler, Per-Olof Berggren, Leif Jansson, and Per-Ola Carlsson
Diabetes 2007 56: 1544 -1550. First published on March 30, 2007 as 10.2337/db06-1258 [Abstract] [Full Text] [PDF]  

Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator

Daniel Johnson, Ruth M. Shepherd, Debra Gill, Tracy Gorman, David M. Smith, and Mark J. Dunne
Diabetes 2007 56: 1694 -1702. First published on March 14, 2007 as 10.2337/db07-0026 [Abstract] [Full Text] [PDF]  

Contribution of Hepatic and Extrahepatic Insulin Resistance to the Pathogenesis of Impaired Fasting Glucose: Role of Increased Rates of Gluconeogenesis

Gerlies Bock, Elizabeth Chittilapilly, Rita Basu, Gianna Toffolo, Claudio Cobelli, Visvanathan Chandramouli, Bernard R. Landau, and Robert A. Rizza
Diabetes 2007 56: 1703 -1711. First published on March 23, 2007 as 10.2337/db06-1776 [Abstract] [Full Text] [PDF]  

Pathophysiology:

Downregulation of GLP-1 and GIP Receptor Expression by Hyperglycemia: Possible Contribution to Impaired Incretin Effects in Diabetes

Gang Xu, Hideaki Kaneto, D. Ross Laybutt, Valerie F. Duvivier-Kali, Nitin Trivedi, Kiyoshi Suzuma, George L. King, Gordon C. Weir, and Susan Bonner-Weir
Diabetes 2007 56: 1551 -1558. First published on March 14, 2007 as 10.2337/db06-1033 [Abstract] [Full Text] [PDF]  

Paradoxical Elevation of High–Molecular Weight Adiponectin in Acquired Extreme Insulin Resistance Due to Insulin Receptor Antibodies

Robert K. Semple, Nils H. Halberg, Keith Burling, Maria A. Soos, Todd Schraw, Jian'an Luan, Elaine K. Cochran, David B. Dunger, Nicholas J. Wareham, Philipp E. Scherer, Phillip Gorden, and Stephen O'Rahilly
Diabetes 2007 56: 1712 -1717. First published on February 26, 2007 as 10.2337/db06-1665 [Abstract] [Full Text] [PDF]  

Complications:

High Glucose Impairs Early and Late Endothelial Progenitor Cells by Modifying Nitric Oxide–Related but Not Oxidative Stress–Mediated Mechanisms

Yung-Hsiang Chen, Shing-Jong Lin, Feng-Yen Lin, Tao-Cheng Wu, Chen-Rong Tsao, Po-Hsun Huang, Po-Len Liu, Yuh-Lien Chen, and Jaw-Wen Chen
Diabetes 2007 56: 1559 -1568. First published on March 26, 2007 as 10.2337/db06-1103 [Abstract] [Full Text] [PDF]  

Pathogenesis of Spinally Mediated Hyperalgesia in Diabetes

Khara M. Ramos, Yun Jiang, Camilla I. Svensson, and Nigel A. Calcutt
Diabetes 2007 56: 1569 -1576. First published on February 7, 2007 as 10.2337/db06-1269 [Abstract] [Full Text] [PDF]  

Genome-Wide Scans for Diabetic Nephropathy and Albuminuria in Multiethnic Populations: The Family Investigation of Nephropathy and Diabetes (FIND)

Sudha K. Iyengar, Hanna E. Abboud, Katrina A.B. Goddard, Mohammed F. Saad, Sharon G. Adler, Nedal H. Arar, Donald W. Bowden, Ravi Duggirala, Robert C. Elston, Robert L. Hanson, Eli Ipp, W.H. Linda Kao, Paul L. Kimmel, Michael J. Klag, William C. Knowler, Lucy A. Meoni, Robert G. Nelson, Susanne B. Nicholas, Madeleine V. Pahl, Rulan S. Parekh, Shannon R.E. Quade, Stephen S. Rich, Jerome I. Rotter, Marina Scavini, Jeffrey R. Schelling, John R. Sedor, Ashwini R. Sehgal, Vallabh O. Shah, Michael W. Smith, Kent D. Taylor, Cheryl A. Winkler, Philip G. Zager, Barry I. Freedman on behalf of the Family Investigation of Nephropathy and Diabetes Research Group
Diabetes 2007 56: 1577 -1585. First published on March 15, 2007 as 10.2337/db06-1154 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Variations in Adiponectin Receptor Genes and Susceptibility to Type 2 Diabetes in Women: A Tagging–Single Nucleotide Polymorphism Haplotype Analysis

Lu Qi, Alessandro Doria, Elena Giorgi, and Frank B. Hu
Diabetes 2007 56: 1586 -1591. First published on April 6, 2007 as 10.2337/db06-1447 [Abstract] [Full Text] [PDF]  

Prevalence and Prognostic Impact of Subclinical Cardiovascular Disease in Individuals With the Metabolic Syndrome and Diabetes

Erik Ingelsson, Lisa M. Sullivan, Joanne M. Murabito, Caroline S. Fox, Emelia J. Benjamin, Joseph F. Polak, James B. Meigs, Michelle J. Keyes, Christopher J. O'Donnell, Thomas J. Wang, Ralph B. D'Agostino, Sr., Philip A. Wolf, and Ramachandran S. Vasan
Diabetes 2007 56: 1718 -1726. First published on March 16, 2007 as 10.2337/db07-0078 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Metabolism:

Mitochondrial Respiration Is Decreased in Skeletal Muscle of Patients With Type 2 Diabetes

Martin Mogensen, Kent Sahlin, Maria Fernström, Dorte Glintborg, Birgitte F. Vind, Henning Beck-Nielsen, and Kurt Højlund
Diabetes 2007 56: 1592 -1599. First published on March 9, 2007 as 10.2337/db06-0981 [Abstract] [Full Text] [PDF]  

The Mammalian Target of Rapamycin Pathway Regulates Nutrient-Sensitive Glucose Uptake in Man

Michael Krebs, Barbara Brunmair, Attila Brehm, Michaela Artwohl, Julia Szendroedi, Peter Nowotny, Erich Roth, Clemens Fürnsinn, Miriam Promintzer, Christian Anderwald, Martin Bischof, and Michael Roden
Diabetes 2007 56: 1600 -1607. First published on February 28, 2007 as 10.2337/db06-1016 [Abstract] [Full Text] [PDF]  

Resistance Exercise and Insulin Regulate AS160 and Interaction With 14-3-3 in Human Skeletal Muscle

Kirsten F. Howlett, Kei Sakamoto, Andrew Garnham, David Cameron-Smith, and Mark Hargreaves
Diabetes 2007 56: 1608 -1614. First published on March 16, 2007 as 10.2337/db06-1398 [Abstract] [Full Text] [PDF]  

Aerobic Exercise Overcomes the Age-Related Insulin Resistance of Muscle Protein Metabolism by Improving Endothelial Function and Akt/Mammalian Target of Rapamycin Signaling

Satoshi Fujita, Blake B. Rasmussen, Jerson G. Cadenas, Micah J. Drummond, Erin L. Glynn, Fred R. Sattler, and Elena Volpi
Diabetes 2007 56: 1615 -1622. First published on March 9, 2007 as 10.2337/db06-1566 [Abstract] [Full Text] [PDF]  

Brief Reports:

Reduction in Microalbuminuria as an Integrated Indicator for Renal and Cardiovascular Risk Reduction in Patients With Type 2 Diabetes

Shin-ichi Araki, Masakazu Haneda, Daisuke Koya, Hideki Hidaka, Toshiro Sugimoto, Motohide Isono, Keiji Isshiki, Masami Chin-Kanasaki, Takashi Uzu, and Atsunori Kashiwagi
Diabetes 2007 56: 1727 -1730. First published on March 14, 2007 as 10.2337/db06-1646 [Abstract] [Full Text] [PDF]  

A Novel Susceptibility Locus on Rat Chromosome 8 Affects Spontaneous but Not Experimentally Induced Type 1 Diabetes

Robert H. Wallis, KeSheng Wang, Dominika Dabrowski, Leili Marandi, Terri Ning, Eugene Hsieh, Andrew D. Paterson, John P. Mordes, Elisabeth P. Blankenhorn, and Philippe Poussier
Diabetes 2007 56: 1731 -1736. First published on March 27, 2007 as 10.2337/db06-1790 [Abstract] [Full Text] [PDF]  

New ABCC8 Mutations in Relapsing Neonatal Diabetes and Clinical Features

Martine Vaxillaire, Aurélie Dechaume, Kanetee Busiah, Hélène Cavé, Sabrina Pereira, Raphael Scharfmann, Guiomar Perez de Nanclares, Luis Castano, Philippe Froguel, Michel Polak and the SUR1–Neonatal Diabetes Study Group
Diabetes 2007 56: 1737 -1741. First published on March 27, 2007 as 10.2337/db06-1540 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Quantitative Trait Loci for Fasting Glucose in Young Europeans Replicate Previous Findings for Type 2 Diabetes in 2q23–24 and Other Locations

Delphine Fradin, Simon Heath, Mark Lathrop, and Pierre Bougnères
Diabetes 2007 56: 1742 -1745. First published on April 6, 2007 as 10.2337/db06-1329 [Abstract] [Full Text] [PDF]  

Errata:

Errata

Diabetes 2007 56: 1746 . [Extract] [Full Text] [PDF]  

Errata

Diabetes 2007 56: 1747 . [Extract] [Full Text] [PDF]  

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