Metabolism:

Neuregulins Increase Mitochondrial Oxidative Capacity and Insulin Sensitivity in Skeletal Muscle Cells

Carles Cantó, Sara Pich, José C. Paz, Rosario Sanches, Vicente Martínez, Meritxell Orpinell, Manuel Palacín, Antonio Zorzano, and Anna Gumà
Diabetes 2007 56: 2185 -2193. First published on June 11, 2007 as 10.2337/db06-1726 [Abstract] [Full Text] [PDF]  

Contraction Stimulates Nitric Oxide–Independent Microvascular Recruitment and Increases Muscle Insulin Uptake

April C. Inyard, Lucy H. Clerk, Michelle A. Vincent, and Eugene J. Barrett
Diabetes 2007 56: 2194 -2200. First published on June 11, 2007 as 10.2337/db07-0020 [Abstract] [Full Text] [PDF]  

Metallothionein Prevents High-Fat Diet–Induced Cardiac Contractile Dysfunction: Role of Peroxisome Proliferator–Activated Receptor Coactivator 1 and Mitochondrial Biogenesis

Feng Dong, Qun Li, Nair Sreejayan, Jennifer M. Nunn, and Jun Ren
Diabetes 2007 56: 2201 -2212. First published on June 15, 2007 as 10.2337/db06-1596 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Physiological Hyperinsulinemia Has No Detectable Effect on Access of Macromolecules to Insulin-Sensitive Tissues in Healthy Humans

Heinz Weinhandl, Christoph Pachler, Julia K. Mader, Dimas Ikeoka, Agnes Mautner, Andreas Falk, Maria Suppan, Thomas R. Pieber, and Martin Ellmerer
Diabetes 2007 56: 2213 -2217. First published on June 29, 2007 as 10.2337/db07-0238 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Signal Transduction:

Characterization of a Protein Kinase B Inhibitor In Vitro and in Insulin-Treated Liver Cells

Lisa Logie, Antonio J. Ruiz-Alcaraz, Michael Keane, Yvonne L. Woods, Jennifer Bain, Rudolfo Marquez, Dario R. Alessi, and Calum Sutherland
Diabetes 2007 56: 2218 -2227. First published on June 11, 2007 as 10.2337/db07-0343 [Abstract] [Full Text] [PDF] Online-Only Appendix  

AMP Kinase Activation Increases Glucose Uptake, Decreases Apoptosis, and Improves Pregnancy Outcome in Embryos Exposed to High IGF-I Concentrations

Grace S. Eng, Rachael A. Sheridan, Amanda Wyman, Maggie M.-Y. Chi, Kristin P. Bibee, Emily S. Jungheim, and Kelle H. Moley
Diabetes 2007 56: 2228 -2234. First published on June 15, 2007 as 10.2337/db07-0074 [Abstract] [Full Text] [PDF]  

Normalization of Prandial Blood Glucose and Improvement of Glucose Tolerance by Liver-Specific Inhibition of SH2 Domain–Containing Inositol Phosphatase 2 (SHIP2) in Diabetic KKA^y Mice: SHIP2 Inhibition Causes Insulin-Mimetic Effects on Glycogen Metabolism, Gluconeogenesis, and Glycolysis

Rolf Grempler, Darya Zibrova, Corinna Schoelch, André van Marle, Joerg F. Rippmann, and Norbert Redemann
Diabetes 2007 56: 2235 -2241. First published on June 27, 2007 as 10.2337/db06-1660 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Obesity Studies:

Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue

Karen E. Inouye, Hang Shi, Jane K. Howard, Christine H. Daly, Graham M. Lord, Barrett J. Rollins, and Jeffrey S. Flier
Diabetes 2007 56: 2242 -2250. First published on May 1, 2007 as 10.2337/db07-0425 [Abstract] [Full Text] [PDF]  

Immunology and Transplantation:

Bone Marrow Is a Preferential Homing Site for Autoreactive T-Cells in Type 1 Diabetes

Ruobing Li, Nicolas Perez, Subha Karumuthil-Melethil, and Chenthamarakshan Vasu
Diabetes 2007 56: 2251 -2259. First published on June 27, 2007 as 10.2337/db07-0502 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion

Chang Yeop Han, Savitha Subramanian, Christina K. Chan, Mohamed Omer, Tsuyoshi Chiba, Thomas N. Wight, and Alan Chait
Diabetes 2007 56: 2260 -2273. First published on June 11, 2007 as 10.2337/db07-0218 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Angiopoietin-1 Production in Islets Improves Islet Engraftment and Protects Islets From Cytokine-Induced Apoptosis

Dongming Su, Nan Zhang, Jing He, Shen Qu, Sandra Slusher, Rita Bottino, Suzanne Bertera, Jonathan Bromberg, and H. Henry Dong
Diabetes 2007 56: 2274 -2283. First published on June 27, 2007 as 10.2337/db07-0371 [Abstract] [Full Text] [PDF]  

Islet Studies:

Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic ß-Cell Apoptosis

Sílvia Casas, Ramon Gomis, Fiona M. Gribble, Jordi Altirriba, Sakari Knuutila, and Anna Novials
Diabetes 2007 56: 2284 -2294. First published on June 11, 2007 as 10.2337/db07-0178 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Metabolic Mechanisms of Failure of Intraportally Transplanted Pancreatic ß-Cells in Rats: Role of Lipotoxicity and Prevention by Leptin

Young Lee, Mariella Ravazzola, Byung-Hyun Park, Yuriy K. Bashmakov, Lelio Orci, and Roger H. Unger
Diabetes 2007 56: 2295 -2301. First published on June 11, 2007 as 10.2337/db07-0460 [Abstract] [Full Text] [PDF]  

Distinct In Vivo Roles of Caspase-8 in ß-Cells in Physiological and Diabetes Models

Nicole Liadis, Leonardo Salmena, Edwin Kwan, Panteha Tajmir, Stephanie A. Schroer, Anna Radziszewska, Xie Li, Laura Sheu, Mohamed Eweida, Shilong Xu, Herbert Y. Gaisano, Razqallah Hakem, and Minna Woo
Diabetes 2007 56: 2302 -2311. First published on June 11, 2007 as 10.2337/db06-1771 [Abstract] [Full Text] [PDF]  

Normal Relationship of ß- and Non–ß-Cells Not Needed for Successful Islet Transplantation

Aileen J.F. King, Justin R. Fernandes, Jennifer Hollister-Lock, Cameron E. Nienaber, Susan Bonner-Weir, and Gordon C. Weir
Diabetes 2007 56: 2312 -2318. First published on June 11, 2007 as 10.2337/db07-0191 [Abstract] [Full Text] [PDF]  

Ghrelin Uses G_i2 and Activates Voltage-Dependent K⁺ Channels to Attenuate Glucose-Induced Ca²⁺ Signaling and Insulin Release in Islet ß-Cells: Novel Signal Transduction of Ghrelin

Katsuya Dezaki, Masafumi Kakei, and Toshihiko Yada
Diabetes 2007 56: 2319 -2327. First published on June 15, 2007 as 10.2337/db07-0345 [Abstract] [Full Text] [PDF]  

Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic ß-Cell Dysfunction

Mingming Hao, W. Steven Head, Subhadra C. Gunawardana, Alyssa H. Hasty, and David W. Piston
Diabetes 2007 56: 2328 -2338. First published on June 15, 2007 as 10.2337/db07-0056 [Abstract] [Full Text] [PDF]  

Congenital Hyperinsulinism–Associated ABCC8 Mutations That Cause Defective Trafficking of ATP-Sensitive K⁺ Channels: Identification and Rescue

Fei-Fei Yan, Yu-Wen Lin, Courtney MacMullen, Arupa Ganguly, Charles A. Stanley, and Show-Ling Shyng
Diabetes 2007 56: 2339 -2348. First published on June 15, 2007 as 10.2337/db07-0150 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Pathophysiology:

Reduced Expression of Nuclear-Encoded Genes Involved in Mitochondrial Oxidative Metabolism in Skeletal Muscle of Insulin-Resistant Women With Polycystic Ovary Syndrome

Vibe Skov, Dorte Glintborg, Steen Knudsen, Thomas Jensen, Torben A. Kruse, Qihua Tan, Klaus Brusgaard, Henning Beck-Nielsen, and Kurt Højlund
Diabetes 2007 56: 2349 -2355. First published on June 11, 2007 as 10.2337/db07-0275 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

Jan A. Ehses, Aurel Perren, Elisabeth Eppler, Pascale Ribaux, John A. Pospisilik, Ranit Maor-Cahn, Xavier Gueripel, Helga Ellingsgaard, Marten K.J. Schneider, Gregoire Biollaz, Adriano Fontana, Manfred Reinecke, Francoise Homo-Delarche, and Marc Y. Donath
Diabetes 2007 56: 2356 -2370. First published on June 19, 2007 as 10.2337/db06-1650 [Abstract] [Full Text] [PDF]  

Complications:

The Vascular Ectonucleotidase ENTPD1 Is a Novel Renoprotective Factor in Diabetic Nephropathy

David J. Friedman, Helmut G. Rennke, Eva Csizmadia, Keiichi Enjyoji, and Simon C. Robson
Diabetes 2007 56: 2371 -2379. First published on May 1, 2007 as 10.2337/db06-1593 [Abstract] [Full Text] [PDF]  

Proteolytic Degradation of VE-Cadherin Alters the Blood-Retinal Barrier in Diabetes

Deepti Navaratna, Paul G. McGuire, Gina Menicucci, and Arup Das
Diabetes 2007 56: 2380 -2387. First published on May 29, 2007 as 10.2337/db06-1694 [Abstract] [Full Text] [PDF]  

Genetics:

Alcohol Consumption and Type 2 Diabetes: Influence of Genetic Variation in Alcohol Dehydrogenase

Joline W.J. Beulens, Eric B. Rimm, Henk F.J. Hendriks, Frank B. Hu, JoAnn E. Manson, David J. Hunter, and Kenneth J. Mukamal
Diabetes 2007 56: 2388 -2394. First published on June 11, 2007 as 10.2337/db07-0181 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Brief Reports:

Hepatic Lipin 1ß Expression Is Diminished in Insulin-Resistant Obese Subjects and Is Reactivated by Marked Weight Loss

Michelle A. Croce, J. Christopher Eagon, Lori L. LaRiviere, Kevin M. Korenblat, Samuel Klein, and Brian N. Finck
Diabetes 2007 56: 2395 -2399. First published on June 11, 2007 as 10.2337/db07-0480 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Screening for Insulitis in Adult Autoantibody-Positive Organ Donors

Peter In't Veld, Dirk Lievens, Joeri De Grijse, Zhidong Ling, Bart Van der Auwera, Miriam Pipeleers-Marichal, Frans Gorus, and Daniel Pipeleers
Diabetes 2007 56: 2400 -2404. First published on June 11, 2007 as 10.2337/db07-0416 [Abstract] [Full Text] [PDF]  

HLA-DPB1*0402 Protects Against Type 1A Diabetes Autoimmunity in the Highest Risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY Population

Erin E. Baschal, Theresa A. Aly, Sunanda R. Babu, Maria S. Fernando, Liping Yu, Dongmei Miao, Katherine J. Barriga, Jill M. Norris, Janelle A. Noble, Henry A. Erlich, Marian J. Rewers, and George S. Eisenbarth
Diabetes 2007 56: 2405 -2409. First published on May 18, 2007 as 10.2337/db07-0029 [Abstract] [Full Text] [PDF]  

A CTG Polymorphism in the CNDP1 Gene Determines the Secretion of Serum Carnosinase in Cos-7–Transfected Cells

Eva Riedl, Hannes Koeppel, Paul Brinkkoetter, Paula Sternik, Herbert Steinbeisser, Sibylle Sauerhoefer, Bart Janssen, Fokko J. van der Woude, and Benito A. Yard
Diabetes 2007 56: 2410 -2413. First published on June 29, 2007 as 10.2337/db07-0128 [Abstract] [Full Text] [PDF]  

Online Letters to the Editor:

Comment on: Hosagai et al. (2007) Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation: Diabetes 56:901–911

Paul Trayhurn, Bohan Wang, and I. Stuart Wood
Diabetes 2007 56: e14 . [Extract] [Full Text] [PDF]  

Comment on: Harmancey et al. (2007) Adrenomedullin Inhibits Adipogenesis Under Transcriptional Control of Insulin: Diabetes 56:553–563

Kazuhiro Takahashi
Diabetes 2007 56: e15 . [Extract] [Full Text] [PDF]  

Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

Santiago Rodriguez, Tom R. Gaunt, Igor Vorechovsky, Jana Kralovicová, Peter J. Wood, and Ian N.M. Day
Diabetes 2007 56: e16 . [Extract] [Full Text] [PDF]  

Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

Luc Marchand and Constantin Polychronakos
Diabetes 2007 56: e17 . [Extract] [Full Text] [PDF]  

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