Commentaries:

An Apparent Role for Alox15 in the Pathogenesis of Diabetes in the NOD Mouse: Parsing the Supporting Genetic Data

Stuart P. Weisberg and Rudolph L. Leibel
Diabetes 2008 57: 1 -2. [Extract] [Full Text] [PDF]  

Diabetes and Protein Metabolism

Niels Møller and K. Sreekumaran Nair
Diabetes 2008 57: 3 -4. [Extract] [Full Text] [PDF]  

Metabolism:

Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E–Deficient Mice

Susanna M. Hofmann, Diego Perez-Tilve, Todd M. Greer, Beth A. Coburn, Erin Grant, Joshua E. Basford, Matthias H. Tschöp, and David Y. Hui
Diabetes 2008 57: 5 -12. First published on October 3, 2007 as 10.2337/db07-0403 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Denervation and High-Fat Diet Reduce Insulin Signaling in T-Tubules in Skeletal Muscle of Living Mice

Hans P.M. Mortensen Lauritzen, Thorkil Ploug, Hua Ai, Morten Donsmark, Clara Prats, and Henrik Galbo
Diabetes 2008 57: 13 -23. First published on October 3, 2007 as 10.2337/db07-0516 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Comparison of the Effects of Pioglitazone and Metformin on Hepatic and Extra-Hepatic Insulin Action in People With Type 2 Diabetes

Rita Basu, Pankaj Shah, Ananda Basu, Barbara Norby, Betty Dicke, Visvanathan Chandramouli, Ohad Cohen, Bernard R. Landau, and Robert A. Rizza
Diabetes 2008 57: 24 -31. First published on October 3, 2007 as 10.2337/db07-0827 [Abstract] [Full Text] [PDF]  

Fatty Acids and Insulin Modulate Myocardial Substrate Metabolism in Humans With Type 1 Diabetes

Linda R. Peterson, Pilar Herrero, Janet McGill, Kenneth B. Schechtman, Zulfia Kisrieva-Ware, Donna Lesniak, and Robert J. Gropler
Diabetes 2008 57: 32 -40. First published on October 3, 2007 as 10.2337/db07-1199 [Abstract] [Full Text] [PDF]  

Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes: Formation of S-(2-Succinyl)Cysteine, a Novel Chemical Modification of Protein and Possible Biomarker of Mitochondrial Stress

Matthew Blatnik, Norma Frizzell, Suzanne R. Thorpe, and John W. Baynes
Diabetes 2008 57: 41 -49. First published on October 12, 2007 as 10.2337/db07-0838 [Abstract] [Full Text] [PDF]  

Evidence That Processes Other Than Gluconeogenesis May Influence the Ratio of Deuterium on the Fifth and Third Carbons of Glucose: Implications for the Use of ²H₂O to Measure Gluconeogenesis in Humans

Gerlies Bock, William C. Schumann, Rita Basu, Shawn C. Burgess, Zheng Yan, Visvanathan Chandramouli, Robert A. Rizza, and Bernard R. Landau
Diabetes 2008 57: 50 -55. First published on October 12, 2007 as 10.2337/db07-0694 [Abstract] [Full Text] [PDF]  

Insulin Resistance of Protein Metabolism in Type 2 Diabetes

Sandra Pereira, Errol B. Marliss, José A. Morais, Stéphanie Chevalier, and Réjeanne Gougeon
Diabetes 2008 57: 56 -63. First published on October 16, 2007 as 10.2337/db07-0887 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Acute Diabetes Moderates Trafficking of Cardiac Lipoprotein Lipase Through p38 Mitogen-Activated Protein Kinase–Dependent Actin Cytoskeleton Organization

Min Suk Kim, Girish Kewalramani, Prasanth Puthanveetil, Vivian Lee, Ujendra Kumar, Ding An, Ashraf Abrahani, and Brian Rodrigues
Diabetes 2008 57: 64 -76. First published on October 17, 2007 as 10.2337/db07-0832 [Abstract] [Full Text] [PDF]  

Signal Transduction:

Resistance to Diet-Induced Obesity and Improved Insulin Sensitivity in Mice With a Regulator of G Protein Signaling–Insensitive G184S Gnai2 Allele

Xinyan Huang, Raelene A. Charbeneau, Ying Fu, Kuljeet Kaur, Isabelle Gerin, Ormond A. MacDougald, and Richard R. Neubig
Diabetes 2008 57: 77 -85. First published on October 10, 2007 as 10.2337/db07-0599 [Abstract] [Full Text] [PDF]  

Obesity Studies:

In Vivo Evidence for Inverse Agonism of Agouti-Related Peptide in the Central Nervous System of Proopiomelanocortin-Deficient Mice

Virginie Tolle and Malcolm J. Low
Diabetes 2008 57: 86 -94. First published on October 1, 2007 as 10.2337/db07-0733 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation

Camilla H. Andreasen, Kirstine L. Stender-Petersen, Mette S. Mogensen, Signe S. Torekov, Lise Wegner, Gitte Andersen, Arne L. Nielsen, Anders Albrechtsen, Knut Borch-Johnsen, Signe S. Rasmussen, Jesper O. Clausen, Annelli Sandbæk, Torsten Lauritzen, Lars Hansen, Torben Jørgensen, Oluf Pedersen, and Torben Hansen
Diabetes 2008 57: 95 -101. First published on October 17, 2007 as 10.2337/db07-0910 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Immunology and Transplantation:

Stromal Cell–Derived Factor-1/CXCL12 Stimulates Chemorepulsion of NOD/LtJ T-Cell Adhesion to Islet Microvascular Endothelium

Christopher D. Sharp, Meng Huang, John Glawe, D. Ross Patrick, Sible Pardue, Shayne C. Barlow, and Christopher G. Kevil
Diabetes 2008 57: 102 -112. First published on October 1, 2007 as 10.2337/db07-0494 [Abstract] [Full Text] [PDF]  

Functional Waning of Naturally Occurring CD4⁺ Regulatory T-Cells Contributes to the Onset of Autoimmune Diabetes

Michael Tritt, Evridiki Sgouroudis, Eva d'Hennezel, Alexandre Albanese, and Ciriaco A. Piccirillo
Diabetes 2008 57: 113 -123. First published on October 10, 2007 as 10.2337/db06-1700 [Abstract] [Full Text] [PDF]  

Islet Studies:

The Role of Nitric Oxide and the Unfolded Protein Response in Cytokine-Induced β-Cell Death

Kari T. Chambers, Julie A. Unverferth, Sarah M. Weber, Ronald C. Wek, Fumihiko Urano, and John A. Corbett
Diabetes 2008 57: 124 -132. First published on October 10, 2007 as 10.2337/db07-0944 [Abstract] [Full Text] [PDF]  

Long-Range Enhancers Are Required to Maintain Expression of the Autoantigen Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein in Adult Mouse Islets In Vivo

Yingda Wang, Brian P. Flemming, Cyrus C. Martin, Shelley R. Allen, Jay Walters, James K. Oeser, John C. Hutton, and Richard M. O'Brien
Diabetes 2008 57: 133 -141. First published on October 17, 2007 as 10.2337/db07-0092 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Partial Pancreatectomy in Adult Humans Does Not Provoke β-Cell Regeneration

Bjoern A. Menge, Andrea Tannapfel, Orlin Belyaev, Robert Drescher, Christophe Müller, Waldemar Uhl, Wolfgang E. Schmidt, and Juris J. Meier
Diabetes 2008 57: 142 -149. First published on October 24, 2007 as 10.2337/db07-1294 [Abstract] [Full Text] [PDF]  

Pathophysiology:

MT1-MMP Expression in First-Trimester Placental Tissue Is Upregulated in Type 1 Diabetes as a Result of Elevated Insulin and Tumor Necrosis Factor- Levels

Ursula Hiden, Elisabeth Glitzner, Marina Ivanisevic, Josip Djelmis, Christian Wadsack, Uwe Lang, and Gernot Desoye
Diabetes 2008 57: 150 -157. First published on October 10, 2007 as 10.2337/db07-0903 [Abstract] [Full Text] [PDF]  

Electronegative LDL Impairs Vascular Endothelial Cell Integrity in Diabetes by Disrupting Fibroblast Growth Factor 2 (FGF2) Autoregulation

Jonathan Lu, Wei Jiang, Jun-Hai Yang, Po-Yuan Chang, Jeffrey P. Walterscheid, Hsin-Hung Chen, Marco Marcelli, Daming Tang, Yuan-Teh Lee, Warren S.L. Liao, Chao-Yuh Yang, and Chu-Huang Chen
Diabetes 2008 57: 158 -166. First published on October 24, 2007 as 10.2337/db07-1287 [Abstract] [Full Text] [PDF]  

Endothelial Dysfunction and C-Reactive Protein Are Risk Factors for Diabetes in Essential Hypertension

Francesco Perticone, Raffele Maio, Angela Sciacqua, Francesco Andreozzi, Giuseppina Iemma, Maria Perticone, Carmine Zoccali, and Giorgio Sesti
Diabetes 2008 57: 167 -171. First published on October 10, 2007 as 10.2337/db07-1189 [Abstract] [Full Text] [PDF]  

Complications:

Expression of N^G,N^G-Dimethylarginine Dimethylaminohydrolase and Protein Arginine N-Methyltransferase Isoforms in Diabetic Rat Kidney: Effects of Angiotensin II Receptor Blockers

Maristela L. Onozato, Akihiro Tojo, James Leiper, Toshiro Fujita, Fredrik Palm, and Christopher S. Wilcox
Diabetes 2008 57: 172 -180. First published on October 1, 2007 as 10.2337/db06-1772 [Abstract] [Full Text] [PDF]  

Neuritin Mediates Nerve Growth Factor–Induced Axonal Regeneration and Is Deficient in Experimental Diabetic Neuropathy

Eugenia Karamoysoyli, Rebecca C. Burnand, David R. Tomlinson, and Natalie J. Gardiner
Diabetes 2008 57: 181 -189. First published on October 1, 2007 as 10.2337/db07-0895 [Abstract] [Full Text] [PDF]  

Pharmacology and Therapeutics:

Differential Antidiabetic Efficacy of Incretin Agonists Versus DPP-4 Inhibition in High Fat–Fed Mice

Benjamin J. Lamont and Daniel J. Drucker
Diabetes 2008 57: 190 -198. First published on October 10, 2007 as 10.2337/db07-1202 [Abstract] [Full Text] [PDF]  

Genetics:

Nonobese Diabetic (NOD) Mice Congenic for a Targeted Deletion of 12/15-Lipoxygenase Are Protected From Autoimmune Diabetes

Marcia McDuffie, Nelly A. Maybee, Susanna R. Keller, Brian K. Stevens, James C. Garmey, Margaret A. Morris, Elizabeth Kropf, Claudia Rival, Kaiwen Ma, Jeffrey D. Carter, Sarah A. Tersey, Craig S. Nunemaker, and Jerry L. Nadler
Diabetes 2008 57: 199 -208. First published on October 16, 2007 as 10.2337/db07-0830 [Abstract] [Full Text] [PDF]  

Genetic Variants Within the LPIN1 Gene, Encoding Lipin, Are Influencing Phenotypes of the Metabolic Syndrome in Humans

Silke Wiedmann, Marcus Fischer, Martina Koehler, Katharina Neureuther, Guenter Riegger, Angela Doering, Heribert Schunkert, Christian Hengstenberg, and Andrea Baessler
Diabetes 2008 57: 209 -217. First published on October 16, 2007 as 10.2337/db07-0083 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Multiple Superoxide Dismutase 1/Splicing Factor Serine Alanine 15 Variants Are Associated With the Development and Progression of Diabetic Nephropathy: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics Study

Hussam Al-Kateb, Andrew P. Boright, Lucia Mirea, Xinlei Xie, Rinku Sutradhar, Alireza Mowjoodi, Bhupinder Bharaj, Michelle Liu, Jean M. Bucksa, Valerie L. Arends, Michael W. Steffes, Patricia A. Cleary, Wanjie Sun, John M. Lachin, Paul S. Thorner, Michael Ho, Amy Jayne McKnight, A. Peter Maxwell, David A. Savage, Kenneth K. Kidd, Judith R. Kidd, William C. Speed, Trevor J. Orchard, Rachel G. Miller, Lei Sun, Shelley B. Bull, Andrew D. Paterson, and the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
Diabetes 2008 57: 218 -228. First published on October 3, 2007 as 10.2337/db07-1059 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes

Magdalena Zoledziewska, Chiara Perra, Valeria Orrù, Loredana Moi, Paola Frongia, Mauro Congia, Nunzio Bottini, and Francesco Cucca
Diabetes 2008 57: 229 -234. First published on October 12, 2007 as 10.2337/db07-0289 [Abstract] [Full Text] [PDF]  

Genome-Wide Scan for Estimated Glomerular Filtration Rate in Multi-Ethnic Diabetic Populations: The Family Investigation of Nephropathy and Diabetes (FIND)

Jeffrey R. Schelling, Hanna E. Abboud, Susanne B. Nicholas, Madeleine V. Pahl, John R. Sedor, Sharon G. Adler, Nedal H. Arar, Donald W. Bowden, Robert C. Elston, Barry I. Freedman, Katrina A.B. Goddard, Xiuqing Guo, Robert L. Hanson, Eli Ipp, Sudha K. Iyengar, Gyungah Jun, W.H. Linda Kao, Balakuntalam S. Kasinath, Paul L. Kimmel, Michael J. Klag, William C. Knowler, Robert G. Nelson, Rulan S. Parekh, Shannon R. Quade, Stephen S. Rich, Mohammed F. Saad, Marina Scavini, Michael W. Smith, Kent Taylor, Cheryl A. Winkler, Philip G. Zager, Vallabh O. Shah on behalf of the Family Investigation of Nephropathy and Diabetes Research Group
Diabetes 2008 57: 235 -243. First published on November 14, 2007 as 10.2337/db07-0313 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study

Martine Vaxillaire, Jacques Veslot, Christian Dina, Christine Proença, Stéphane Cauchi, Guillaume Charpentier, Jean Tichet, Frédéric Fumeron, Michel Marre, David Meyre, Beverley Balkau, Philippe Froguel for the DESIR Study Group
Diabetes 2008 57: 244 -254. First published on October 31, 2007 as 10.2337/db07-0615 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Mosaic Paternal Uniparental Isodisomy and an ABCC8 Gene Mutation in a Patient With Permanent Neonatal Diabetes and Hemihypertrophy

Julian P.H. Shield, Sarah E. Flanagan, Deborah J. Mackay, Lorna W. Harries, Peter Proks, Christophe Girard, Frances M. Ashcroft, I. Karen Temple, and Sian Ellard
Diabetes 2008 57: 255 -258. First published on October 17, 2007 as 10.2337/db07-0999 [Abstract] [Full Text] [PDF]  

An ABCC8 Gene Mutation and Mosaic Uniparental Isodisomy Resulting in Atypical Diffuse Congenital Hyperinsulinism

Khalid Hussain, Sarah E. Flanagan, Virpi V. Smith, Michael Ashworth, Michael Day, Agostino Pierro, and Sian Ellard
Diabetes 2008 57: 259 -263. First published on October 17, 2007 as 10.2337/db07-0998 [Abstract] [Full Text] [PDF]  

Variants in the Fat Mass–and Obesity-Associated (FTO) Gene Are Not Associated With Obesity in a Chinese Han Population

Huaixing Li, Ying Wu, Ruth J.F. Loos, Frank B. Hu, Yong Liu, Jing Wang, Zhijie Yu, and Xu Lin
Diabetes 2008 57: 264 -268. First published on October 24, 2007 as 10.2337/db07-1130 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Unaltered Diabetes Presentation in NOD Mice Lacking the Vitamin D Receptor

Conny Gysemans, Evelyne van Etten, Lutgart Overbergh, Annapaula Giulietti, Guy Eelen, Mark Waer, Annemieke Verstuyf, Roger Bouillon, and Chantal Mathieu
Diabetes 2008 57: 269 -275. First published on October 24, 2007 as 10.2337/db07-1095 [Abstract] [Full Text] [PDF] Online-Only Appendix  

Online Letters to the Editor:

Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959

Simeon Pierre Choukem and Jean-François Gautier
Diabetes 2008 57: e1 . [Extract] [Full Text] [PDF]  

Response to Comment on: Knop et al. (2007) Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes 56:1951–1959

Filip K. Knop, Tina Vilsbøll, Sten Madsbad, Thure Krarup, and Jens J. Holst
Diabetes 2008 57: e2 -e3. [Extract] [Full Text] [PDF]  

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