Diabetes -- Table of Contents (April 2008, 57 [4])

Commentaries:

Thioredoxin-Interacting Protein Is Killing My β-cells!: John A. Corbett
Diabetes 2008 57: 797 -798. [Extract] [Full Text] [PDF]

Insulin Mutations in Diabetes: The Clinical Spectrum: Benjamin Glaser
Diabetes 2008 57: 799 -800. [Extract] [Full Text] [PDF]

Metabolism:

Omentin-1, a Novel Adipokine, Is Decreased in Overweight Insulin-Resistant Women With Polycystic Ovary Syndrome: Ex Vivo and In Vivo Regulation of Omentin-1 by Insulin and Glucose: Bee K. Tan, Raghu Adya, S. Farhatullah, Kris C. Lewandowski, Paul O’Hare, Hendrik Lehnert, and Harpal S. Randeva
Diabetes 2008 57: 801 -808. First published on January 3, 2008 as 10.2337/db07-0990 [Abstract] [Full Text] [PDF] Online-Only Appendix

PPARGC1A Variation Associated With DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Health Study: Chao-Qiang Lai, Katherine L. Tucker, Laurence D. Parnell, Xian Adiconis, Bibiana García-Bailo, John Griffith, Mohsen Meydani, and José M. Ordovás
Diabetes 2008 57: 809 -816. First published on December 27, 2007 as 10.2337/db07-1238 [Abstract] [Full Text] [PDF] Online-Only Appendix Online-Only Appendix

Homocysteine Upregulates Resistin Production From Adipocytes In Vivo and In Vitro: Yin Li, Changtao Jiang, Guoheng Xu, Nanping Wang, Yi Zhu, Chaoshu Tang, and Xian Wang
Diabetes 2008 57: 817 -827. First published on January 11, 2008 as 10.2337/db07-0617 [Abstract] [Full Text] [PDF]

Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal: Jenny D. Chiu, Joyce M. Richey, L. Nicole Harrison, Edward Zuniga, Cathryn M. Kolka, Erlinda Kirkman, Martin Ellmerer, and Richard N. Bergman
Diabetes 2008 57: 828 -835. First published on January 25, 2008 as 10.2337/db07-1444 [Abstract] [Full Text] [PDF]

Activation of Central Lactate Metabolism Lowers Glucose Production in Uncontrolled Diabetes and Diet-Induced Insulin Resistance: Madhu Chari, Carol K.L. Lam, Penny Y.T. Wang, and Tony K.T. Lam
Diabetes 2008 57: 836 -840. First published on January 9, 2008 as 10.2337/db07-1464 [Abstract] [Full Text] [PDF]

Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate: Jose E. Galgani, Leonie K. Heilbronn, Koichiro Azuma, David E. Kelley, Jeanine B. Albu, Xavier Pi-Sunyer, Steven R. Smith, Eric Ravussin and the Look AHEAD Adipose Research Group
Diabetes 2008 57: 841 -845. First published on February 19, 2008 as 10.2337/db08-0043 [Abstract] [Full Text] [PDF]

Signal Transduction:

Inhibition of Foxo1 Protects Pancreatic Islet β-Cells Against Fatty Acid and Endoplasmic Reticulum Stress–Induced Apoptosis: Sara C. Martinez, Katsuya Tanabe, Corentin Cras-Méneur, Nada A. Abumrad, Ernesto Bernal-Mizrachi, and M. Alan Permutt
Diabetes 2008 57: 846 -859. First published on January 3, 2008 as 10.2337/db07-0595 [Abstract] [Full Text] [PDF] Online-Only Appendix

AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5: Sean L. McGee, Bryce J.W. van Denderen, Kirsten F. Howlett, Janelle Mollica, Jonathan D. Schertzer, Bruce E. Kemp, and Mark Hargreaves
Diabetes 2008 57: 860 -867. First published on January 9, 2008 as 10.2337/db07-0843 [Abstract] [Full Text] [PDF] Online-Only Appendix

Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca²⁺ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets: Byung-Ju Kim, Kwang-Hyun Park, Chang-Yeol Yim, Shin Takasawa, Hiroshi Okamoto, Mie-Jae Im, and Uh-Hyun Kim
Diabetes 2008 57: 868 -878. First published on January 9, 2008 as 10.2337/db07-0443 [Abstract] [Full Text] [PDF] Online-Only Appenidx

Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes: Narkunarajaa Shanmugam, James L. Figarola, Yan Li, Piotr M. Swiderski, Samual Rahbar, and Rama Natarajan
Diabetes 2008 57: 879 -888. First published on November 14, 2007 as 10.2337/db07-1204 [Abstract] [Full Text] [PDF] Online-Only Appendix

Peroxynitrite Mediates Retinal Neurodegeneration by Inhibiting Nerve Growth Factor Survival Signaling in Experimental and Human Diabetes: Tayyeba K. Ali, Suraporn Matragoon, Bindu A. Pillai, Gregory I. Liou, and Azza B. El-Remessy
Diabetes 2008 57: 889 -898. First published on February 19, 2008 as 10.2337/db07-1669 [Abstract] [Full Text] [PDF] Online-Only Appendix

Obesity Studies:

Physiological and Molecular Determinants of Insulin Action in the Baboon: Alberto O. Chavez, Juan C. Lopez-Alvarenga, M. Elizabeth Tejero, Curtis Triplitt, Raul A. Bastarrachea, Apiradee Sriwijitkamol, Puntip Tantiwong, V. Saroja Voruganti, Nicolas Musi, Anthony G. Comuzzie, Ralph A. DeFronzo, and Franco Folli
Diabetes 2008 57: 899 -908. First published on January 3, 2008 as 10.2337/db07-0790 [Abstract] [Full Text] [PDF] Online-Only Appendix

Immunology and Transplantation:

B-Cells Promote Intra-Islet CD8⁺ Cytotoxic T-Cell Survival to Enhance Type 1 Diabetes: Gillian M. Brodie, Maja Wallberg, Pere Santamaria, F. Susan Wong, and E. Allison Green
Diabetes 2008 57: 909 -917. First published on January 9, 2008 as 10.2337/db07-1256 [Abstract] [Full Text] [PDF]

Targeting of Pancreatic Glia in Type 1 Diabetes: Hubert Tsui, Yin Chan, Lan Tang, Shawn Winer, Roy K. Cheung, Geoffrey Paltser, Thirumahal Selvanantham, Alisha R. Elford, James R. Ellis, Dorothy J. Becker, Pamela S. Ohashi, and Hans-Michael Dosch
Diabetes 2008 57: 918 -928. First published on January 15, 2008 as 10.2337/db07-0226 [Abstract] [Full Text] [PDF] Online-Only Appendix

Association of IL-1ra and Adiponectin With C-Peptide and Remission in Patients With Type 1 Diabetes: Christian Pfleger, Henrik B. Mortensen, Lars Hansen, Christian Herder, Bart O. Roep, Hillary Hoey, Henk-Jan Aanstoot, Mirjana Kocova, Nanette C. Schloot on behalf of the Hvidøre Study Group on Childhood Diabetes
Diabetes 2008 57: 929 -937. First published on February 25, 2008 as 10.2337/db07-1697 [Abstract] [Full Text] [PDF] Online-Only Appendix

Islet Studies:

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and β-Cell Apoptosis: Junqin Chen, Geetu Saxena, Imran N. Mungrue, Aldons J. Lusis, and Anath Shalev
Diabetes 2008 57: 938 -944. First published on January 2, 2008 as 10.2337/db07-0715 [Abstract] [Full Text] [PDF]

mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes: Merav Fraenkel, Mali Ketzinel-Gilad, Yafa Ariav, Orit Pappo, Melis Karaca, Julien Castel, Marie-France Berthault, Christophe Magnan, Erol Cerasi, Nurit Kaiser, and Gil Leibowitz
Diabetes 2008 57: 945 -957. First published on January 3, 2008 as 10.2337/db07-0922 [Abstract] [Full Text] [PDF] Online-Only Appendix

Regulated β-Cell Regeneration in the Adult Mouse Pancreas: David A. Cano, Ingrid C. Rulifson, Patrick W. Heiser, Lamorna B. Swigart, Stella Pelengaris, Mike German, Gerard I. Evan, Jeffrey A. Bluestone, and Matthias Hebrok
Diabetes 2008 57: 958 -966. First published on December 14, 2007 as 10.2337/db07-0913 [Abstract] [Full Text] [PDF] Online-Only Appendix

Obestatin Promotes Survival of Pancreatic β-Cells and Human Islets and Induces Expression of Genes Involved in the Regulation of β-Cell Mass and Function: Riccarda Granata, Fabio Settanni, Davide Gallo, Letizia Trovato, Luigi Biancone, Vincenzo Cantaluppi, Rita Nano, Marta Annunziata, Pietro Campiglia, Elisa Arnoletti, Corrado Ghè, Marco Volante, Mauro Papotti, Giampiero Muccioli, and Ezio Ghigo
Diabetes 2008 57: 967 -979. First published on December 27, 2007 as 10.2337/db07-1104 [Abstract] [Full Text] [PDF]

Pathophysiology:

Adiponectin, Change in Adiponectin, and Progression to Diabetes in the Diabetes Prevention Program: Kieren J. Mather, Tohru Funahashi, Yuji Matsuzawa, Sharon Edelstein, George A. Bray, Steven E. Kahn, Jill Crandall, Santica Marcovina, Barry Goldstein, Ronald Goldberg for the Diabetes Prevention Program
Diabetes 2008 57: 980 -986. First published on January 11, 2008 as 10.2337/db07-1419 [Abstract] [Full Text] [PDF] Online-Only Appendix

Mitochondrial Capacity in Skeletal Muscle Is Not Stimulated by Weight Loss Despite Increases in Insulin Action and Decreases in Intramyocellular Lipid Content: Frederico G.S. Toledo, Elizabeth V. Menshikova, Koichiro Azuma, Zofia Radiková, Carol A. Kelley, Vladimir B. Ritov, and David E. Kelley
Diabetes 2008 57: 987 -994. First published on February 5, 2008 as 10.2337/db07-1429 [Abstract] [Full Text] [PDF]

Complications:

Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial—Revisited: John M. Lachin, Saul Genuth, David M. Nathan, Bernard Zinman, Brandy N. Rutledge for the DCCT/EDIC Research Group
Diabetes 2008 57: 995 -1001. First published on January 25, 2008 as 10.2337/db07-1618 [Abstract] [Full Text] [PDF] Online-Only Appendix

Receptor for Advanced Glycation End Products (RAGEs) and Experimental Diabetic Neuropathy: Cory Toth, Ling Ling Rong, Christina Yang, Jose Martinez, Fei Song, Noor Ramji, Valentine Brussee, Wei Liu, Jeff Durand, Minh Dang Nguyen, Ann Marie Schmidt, and Douglas W. Zochodne
Diabetes 2008 57: 1002 -1017. First published on November 26, 2007 as 10.2337/db07-0339 [Abstract] [Full Text] [PDF]

ACE2 Deficiency Modifies Renoprotection Afforded by ACE Inhibition in Experimental Diabetes: Chris Tikellis, Katarzyna Bialkowski, Josepha Pete, Karen Sheehy, Qui Su, Colin Johnston, Mark E. Cooper, and Merlin C. Thomas
Diabetes 2008 57: 1018 -1025. First published on January 30, 2008 as 10.2337/db07-1212 [Abstract] [Full Text] [PDF] Figures

Pharmacology and Therapeutics:

Intravitreal Triamcinolone Acetonide Inhibits Breakdown of the Blood-Retinal Barrier Through Differential Regulation of VEGF-A and Its Receptors in Early Diabetic Rat Retinas: Xinyuan Zhang, Shisan Bao, Donna Lai, Robert W. Rapkins, and Mark C. Gillies
Diabetes 2008 57: 1026 -1033. First published on January 3, 2008 as 10.2337/db07-0982 [Abstract] [Full Text] [PDF]

Genetics:

Insulin Mutation Screening in 1,044 Patients With Diabetes: Mutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood: Emma L. Edghill, Sarah E. Flanagan, Ann-Marie Patch, Chris Boustred, Andrew Parrish, Beverley Shields, Maggie H. Shepherd, Khalid Hussain, Ritika R. Kapoor, Maciej Malecki, Michael J. MacDonald, Julie Støy, Donald F. Steiner, Louis H. Philipson, Graeme I. Bell, the Neonatal Diabetes International Collaborative Group, Andrew T. Hattersley, and Sian Ellard
Diabetes 2008 57: 1034 -1042. First published on December 27, 2007 as 10.2337/db07-1405 [Abstract] [Full Text] [PDF]

A Polymorphism in the Zinc Transporter Gene SLC30A8 Confers Resistance Against Posttransplantation Diabetes Mellitus in Renal Allograft Recipients: Eun Seok Kang, Myoung Soo Kim, Yu Seun Kim, Chul Hoon Kim, Seung Jin Han, Sung Wan Chun, Kyu Yeon Hur, Chung Mo Nam, Chul Woo Ahn, Bong Soo Cha, Soon Il Kim, and Hyun Chul Lee
Diabetes 2008 57: 1043 -1047. First published on December 27, 2007 as 10.2337/db07-0761 [Abstract] [Full Text] [PDF] Online-Only Appendix

Evidence of Interaction Between PPARG2 and HNF4A Contributing to Variation in Insulin Sensitivity in Mexican Americans: Mary Helen Black, Tasha E. Fingerlin, Hooman Allayee, Weiming Zhang, Anny H. Xiang, Enrique Trigo, Jaana Hartiala, Allison B. Lehtinen, Steven M. Haffner, Richard N. Bergman, Richard C. McEachin, Siri L. Kjos, Jean M. Lawrence, Thomas A. Buchanan, and Richard M. Watanabe
Diabetes 2008 57: 1048 -1056. First published on December 27, 2007 as 10.2337/db07-0848 [Abstract] [Full Text] [PDF] Online-Only Appendix

Association of the Distal Region of the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Gene With Type 2 Diabetes in an African-American Population Enriched for Nephropathy: Keith L. Keene, Josyf C. Mychaleckyj, Shelly G. Smith, Tennille S. Leak, Peter S. Perlegas, Carl D. Langefeld, Barry I. Freedman, Stephen S. Rich, Donald W. Bowden, and Michèle M. Sale
Diabetes 2008 57: 1057 -1062. First published on January 9, 2008 as 10.2337/db07-0886 [Abstract] [Full Text] [PDF] Online-Only Appendix

The Common –866G>A Variant in the Promoter of UCP2 Is Associated With Decreased Risk of Coronary Artery Disease in Type 2 Diabetic Men: Nadir Cheurfa, Danièle Dubois-Laforgue, Daniela A.F. Ferrarezi, André F. Reis, Guilherme M. Brenner, Clara Bouché, Claude Le Feuvre, Frédéric Fumeron, José Timsit, Michel Marre, and Gilberto Velho
Diabetes 2008 57: 1063 -1068. First published on January 11, 2008 as 10.2337/db07-1292 [Abstract] [Full Text] [PDF] Online-Only Appendix

HNF4 ${alpha}$ and the Ca-Channel TRPC1 Are Novel Disease Candidate Genes in Diabetic Nephropathy: Monika Niehof and Jürgen Borlak
Diabetes 2008 57: 1069 -1077. First published on January 9, 2008 as 10.2337/db07-1065 [Abstract] [Full Text] [PDF] Online-Only Appendix

Variations of the Perforin Gene in Patients With Type 1 Diabetes: Elisabetta Orilieri, Giuseppe Cappellano, Rita Clementi, Angela Cometa, Massimo Ferretti, Elisa Cerutti, Francesco Cadario, Miryam Martinetti, Daniela Larizza, Valeria Calcaterra, Giuseppe D’Annunzio, Renata Lorini, Franco Cerutti, Graziella Bruno, Annalisa Chiocchetti, and Umberto Dianzani
Diabetes 2008 57: 1078 -1083. First published on January 15, 2008 as 10.2337/db07-0947 [Abstract] [Full Text] [PDF]

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families: Henry Erlich, Ana Maria Valdes, Janelle Noble, Joyce A. Carlson, Mike Varney, Pat Concannon, Josyf C. Mychaleckyj, John A. Todd, Persia Bonella, Anna Lisa Fear, Eva Lavant, Anthony Louey, Priscilla Moonsamy for the Type 1 Diabetes Genetics Consortium
Diabetes 2008 57: 1084 -1092. First published on February 5, 2008 as 10.2337/db07-1331 [Abstract] [Full Text] [PDF] Online-Only Appendix

Quantitative Trait Analysis of Type 2 Diabetes Susceptibility Loci Identified From Whole Genome Association Studies in the Insulin Resistance Atherosclerosis Family Study: Nicholette D. Palmer, Mark O. Goodarzi, Carl D. Langefeld, Julie Ziegler, Jill M. Norris, Steven M. Haffner, Michael Bryer-Ash, Richard N. Bergman, Lynne E. Wagenknecht, Kent D. Taylor, Jerome I. Rotter, and Donald W. Bowden
Diabetes 2008 57: 1093 -1100. First published on February 5, 2008 as 10.2337/db07-1169 [Abstract] [Full Text] [PDF] Online-Only Appendix

Genetic Variants in the UCP2-UCP3 Gene Cluster and Risk of Diabetes in the Women's Health Initiative Observational Study: Yi-Hsiang Hsu, Tianhua Niu, Yiqing Song, Lesley Tinker, Lewis H. Kuller, and Simin Liu
Diabetes 2008 57: 1101 -1107. First published on January 25, 2008 as 10.2337/db07-1269 [Abstract] [Full Text] [PDF]

Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study: Allison B. Lehtinen, Christopher Newton-Cheh, Julie T. Ziegler, Carl D. Langefeld, Barry I. Freedman, Kurt R. Daniel, David M. Herrington, and Donald W. Bowden
Diabetes 2008 57: 1108 -1114. First published on January 30, 2008 as 10.2337/db07-1365 [Abstract] [Full Text] [PDF] Online-Only Appendix

Heterozygous Missense Mutations in the Insulin Gene Are Linked to Permanent Diabetes Appearing in the Neonatal Period or in Early Infancy: A Report From the French ND (Neonatal Diabetes) Study Group: Michel Polak, Aurélie Dechaume, Hélène Cavé, Revital Nimri, Hélène Crosnier, Véronique Sulmont, Marc de Kerdanet, Raphael Scharfmann, Yael Lebenthal, Philippe Froguel, and Martine Vaxillaire
Diabetes 2008 57: 1115 -1119. First published on January 2, 2008 as 10.2337/db07-1358 [Abstract] [Full Text] [PDF]

Quantitative Linkage Analysis for Pancreatic B-cell Function and Insulin Resistance in a Large Twin Cohort: Mario Falchi, Scott G. Wilson, Dimitrios Paximadas, Ramasamyiyer Swaminathan, and Tim D. Spector
Diabetes 2008 57: 1120 -1124. First published on January 3, 2008 as 10.2337/db07-0708 [Abstract] [Full Text] [PDF] Online-Only Appendix

The ENPP1 K121Q Polymorphism Is Associated With Type 2 Diabetes in European Populations: Evidence From an Updated Meta-Analysis in 42,042 Subjects: Jarred B. McAteer, Sabrina Prudente, Simonetta Bacci, Helen N. Lyon, Joel N. Hirschhorn, Vincenzo Trischitta, Jose C. Florez for the ENPP1 Consortium
Diabetes 2008 57: 1125 -1130. First published on December 10, 2007 as 10.2337/db07-1336 [Abstract] [Full Text] [PDF] Online-Only Appendix

Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes: Anders Molven, Monika Ringdal, Anita M. Nordbø, Helge Ræder, Julie Støy, Gregory M. Lipkind, Donald F. Steiner, Louis H. Philipson, Ines Bergmann, Dagfinn Aarskog, Dag E. Undlien, Geir Joner, Oddmund Søvik, the Norwegian Childhood Diabetes Study Group, Graeme I. Bell, and Pål R. Njølstad
Diabetes 2008 57: 1131 -1135. First published on January 11, 2008 as 10.2337/db07-1467 [Abstract] [Full Text] [PDF]

Association of Variants in the Sterol Regulatory Element-Binding Factor 1 (SREBF1) Gene With Type 2 Diabetes, Glycemia, and Insulin Resistance: A Study of 15,734 Danish Subjects: Niels Grarup, Kirstine L. Stender-Petersen, Ehm A. Andersson, Torben Jørgensen, Knut Borch-Johnsen, Annelli Sandbæk, Torsten Lauritzen, Ole Schmitz, Torben Hansen, and Oluf Pedersen
Diabetes 2008 57: 1136 -1142. First published on January 11, 2008 as 10.2337/db07-1534 [Abstract] [Full Text] [PDF] Online-Only Appendix

A Novel Susceptibility Locus for Type 1 Diabetes on Chr12q13 Identified by a Genome-Wide Association Study: Hakon Hakonarson, Hui-Qi Qu, Jonathan P. Bradfield, Luc Marchand, Cecilia E. Kim, Joseph T. Glessner, Rosemarie Grabs, Tracy Casalunovo, Shayne P. Taback, Edward C. Frackelton, Andrew W. Eckert, Kiran Annaiah, Margaret L. Lawson, F. George Otieno, Erin Santa, Julie L. Shaner, Ryan M. Smith, Chioma C. Onyiah, Robert Skraban, Rosetta M. Chiavacci, Luke J. Robinson, Charles A. Stanley, Susan E. Kirsch, Marcella Devoto, Dimitri S. Monos, Struan F.A. Grant, and Constantin Polychronakos
Diabetes 2008 57: 1143 -1146. First published on January 15, 2008 as 10.2337/db07-1305 [Abstract] [Full Text] [PDF]

Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels, and Resting Metabolic Rate in the Quebec Family Study: Ron Do, Swneke D. Bailey, Katia Desbiens, Alexandre Belisle, Alexandre Montpetit, Claude Bouchard, Louis Pérusse, Marie-Claude Vohl, and James C. Engert
Diabetes 2008 57: 1147 -1150. First published on March 3, 2008 as 10.2337/db07-1267 [Abstract] [Full Text] [PDF] Online-Only Appendix