Diabetes -- Table of Contents (May 2008, 57 [5])

Commentaries:

Abdominal Adiposity and Diabetes Risk: The Importance of Precise Measures and Longitudinal Studies: Anthony J.G. Hanley and Lynne E. Wagenknecht
Diabetes 2008 57: 1153 -1155. [Extract] [Full Text] [PDF]

Islet Autoreactive CD8 T-cells in Type 1 Diabetes: Licensed to Kill?: Bart O. Roep
Diabetes 2008 57: 1156 . [Extract] [Full Text] [PDF]

Central Versus Peripheral Glucose Sensing and the Response to Hypoglycemia: Alan D. Cherrington
Diabetes 2008 57: 1158 -1159. [Extract] [Full Text] [PDF]

Genetic Similarities Between Latent Autoimmune Diabetes and Type 1 and Type 2 Diabetes: Andrea K. Steck and George S. Eisenbarth
Diabetes 2008 57: 1160 -1162. [Extract] [Full Text] [PDF]

Editorial:

Intensive Glycemic Control and Cardiovascular Disease Observations From the ACCORD Study: Now What Can a Clinician Possibly Think?: William T. Cefalu and Karol Watson
Diabetes 2008 57: 1163 -1165. [Extract] [Full Text] [PDF]

Metabolism:

Asian Indians Have Enhanced Skeletal Muscle Mitochondrial Capacity to Produce ATP in Association With Severe Insulin Resistance: K. Sreekumaran Nair, Maureen L. Bigelow, Yan W. Asmann, Lisa S. Chow, Jill M. Coenen-Schimke, Katherine A. Klaus, Zeng-Kui Guo, Raghavakaimal Sreekumar, and Brian A. Irving
Diabetes 2008 57: 1166 -1175. First published on February 19, 2008 as 10.2337/db07-1556 [Abstract] [Full Text] [PDF] Online-Only Appendix

Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism: Christopher R. Cederroth, Manlio Vinciguerra, Asllan Gjinovci, Françoise Kühne, Marcella Klein, Manon Cederroth, Dorothée Caille, Mariane Suter, Dietbert Neumann, Richard W. James, Daniel R. Doerge, Theo Wallimann, Paolo Meda, Michelangelo Foti, Françoise Rohner-Jeanrenaud, Jean-Dominique Vassalli, and Serge Nef
Diabetes 2008 57: 1176 -1185. First published on April 16, 2008 as 10.2337/db07-0630 [Abstract] [Full Text] [PDF] Online-Only Appendix

Plasma Free Fatty Acid Storage in Subcutaneous and Visceral Adipose Tissue in Postabsorptive Women: Christina Koutsari, Daniel A. Dumesic, Bruce W. Patterson, Susanne B. Votruba, and Michael D. Jensen
Diabetes 2008 57: 1186 -1194. First published on February 19, 2008 as 10.2337/db07-0664 [Abstract] [Full Text] [PDF]

Signal Transduction:

Rab GTPase-Activating Protein AS160 Is a Major Downstream Effector of Protein Kinase B/Akt Signaling in Pancreatic β-Cells: Karim Bouzakri, Pascale Ribaux, Alejandra Tomas, Geraldine Parnaud, Katharina Rickenbach, and Philippe A. Halban
Diabetes 2008 57: 1195 -1204. First published on February 14, 2008 as 10.2337/db07-1469 [Abstract] [Full Text] [PDF] Figures

Exendin-4 Protects β-Cells From Interleukin-1β–Induced Apoptosis by Interfering With the c-Jun NH₂-Terminal Kinase Pathway: Mourad Ferdaoussi, Saida Abdelli, Jiang-Yan Yang, Marion Cornu, Guy Niederhauser, Dimitri Favre, Christian Widmann, Romano Regazzi, Bernard Thorens, Gérard Waeber, and Amar Abderrahmani
Diabetes 2008 57: 1205 -1215. First published on February 5, 2008 as 10.2337/db07-1214 [Abstract] [Full Text] [PDF]

FALDH Reverses the Deleterious Action of Oxidative Stress Induced by Lipid Peroxidation Product 4-Hydroxynonenal on Insulin Signaling in 3T3-L1 Adipocytes: Damien Demozay, Jean-Christophe Mas, Stephane Rocchi, and Emmanuel Van Obberghen
Diabetes 2008 57: 1216 -1226. First published on January 3, 2008 as 10.2337/db07-0389 [Abstract] [Full Text] [PDF]

STAT3 Sensitizes Insulin Signaling by Negatively Regulating Glycogen Synthase Kinase-3β: Akira Moh, Wenjun Zhang, Sidney Yu, Jun Wang, Xuming Xu, Jiliang Li, and Xin-Yuan Fu
Diabetes 2008 57: 1227 -1235. First published on February 11, 2008 as 10.2337/db06-1582 [Abstract] [Full Text] [PDF] Online-Only Appendix

Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways: Zeynep Dogusan, Mónica García, Daisy Flamez, Lena Alexopoulou, Michel Goldman, Conny Gysemans, Chantal Mathieu, Claude Libert, Decio L. Eizirik, and Joanne Rasschaert
Diabetes 2008 57: 1236 -1245. First published on January 25, 2008 as 10.2337/db07-0844 [Abstract] [Full Text] [PDF] Online-Only Appendix

Obesity Studies:

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans: Xinmei Zhang, Dennis C.Y. Yeung, Michal Karpisek, David Stejskal, Zhi-Guang Zhou, Feng Liu, Rachel L.C. Wong, Wing-Sun Chow, Annette W.K. Tso, Karen S.L. Lam, and Aimin Xu
Diabetes 2008 57: 1246 -1253. First published on February 5, 2008 as 10.2337/db07-1476 [Abstract] [Full Text] [PDF] Online-Only Appendix

Macrophage Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue: Elizabeth A. Kirk, Zachary K. Sagawa, Thomas O. McDonald, Kevin D. O'Brien, and Jay W. Heinecke
Diabetes 2008 57: 1254 -1261. First published on February 11, 2008 as 10.2337/db07-1061 [Abstract] [Full Text] [PDF]

The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids: Tara M. D'Eon, Kerry A. Pierce, Jeffery J. Roix, Andrew Tyler, Hong Chen, and Sandra R. Teixeira
Diabetes 2008 57: 1262 -1268. First published on February 14, 2008 as 10.2337/db07-1186 [Abstract] [Full Text] [PDF]

Visceral Adiposity, Not Abdominal Subcutaneous Fat Area, Is Associated With an Increase in Future Insulin Resistance in Japanese Americans: Tomoshige Hayashi, Edward J. Boyko, Marguerite J. McNeely, Donna L. Leonetti, Steven E. Kahn, and Wilfred Y. Fujimoto
Diabetes 2008 57: 1269 -1275. First published on February 25, 2008 as 10.2337/db07-1378 [Abstract] [Full Text] [PDF]

Immunology and Transplantation:

Identification of Tyrosine Phosphatase 2_(256–760) Construct as a New, Sensitive Marker for the Detection of Islet Autoimmunity in Type 2 Diabetic Patients: The Non–Insulin Requiring Autoimmune Diabetes (NIRAD) Study 2: Claudio Tiberti, Carla Giordano, Mattia Locatelli, Emanuele Bosi, Gian Franco Bottazzo, Raffaella Buzzetti, Domenico Cucinotta, Aldo Galluzzo, Alberto Falorni, and Francesco Dotta
Diabetes 2008 57: 1276 -1283. First published on March 10, 2008 as 10.2337/db07-0874 [Abstract] [Full Text] [PDF] Online-Only Appendix

Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells: Mark D. McKenzie, Emma M. Carrington, Thomas Kaufmann, Andreas Strasser, David C.S. Huang, Thomas W.H. Kay, Janette Allison, and Helen E. Thomas
Diabetes 2008 57: 1284 -1292. First published on February 5, 2008 as 10.2337/db07-1692 [Abstract] [Full Text] [PDF] Online-Only Appendix Figures

COOH-Terminal Clustering of Autoantibody and T-Cell Determinants on the Structure of GAD65 Provide Insights Into the Molecular Basis of Autoreactivity: Gustavo Fenalti, Christiane S. Hampe, Yasir Arafat, Ruby H.P. Law, J. Paul Banga, Ian R. Mackay, James C. Whisstock, Ashley M. Buckle, and Merrill J. Rowley
Diabetes 2008 57: 1293 -1301. First published on January 9, 2008 as 10.2337/db07-1461 [Abstract] [Full Text] [PDF]

Regulatory T-Cells Protect From Type 1 Diabetes After Induction by Coxsackievirus Infection in the Context of Transforming Growth Factor-β: Martin J. Richer, Nadine Straka, Dianne Fang, Iryna Shanina, and Marc S. Horwitz
Diabetes 2008 57: 1302 -1311. First published on February 11, 2008 as 10.2337/db07-1460 [Abstract] [Full Text] [PDF] Online-Only Appendix Figures

The Frequency and Immunodominance of Islet-Specific CD8⁺ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment: Emanuela Martinuzzi, Giulia Novelli, Matthieu Scotto, Philippe Blancou, Jean-Marie Bach, Lucy Chaillous, Graziella Bruno, Lucienne Chatenoud, Peter van Endert, and Roberto Mallone
Diabetes 2008 57: 1312 -1320. First published on February 27, 2008 as 10.2337/db07-1594 [Abstract] [Full Text] [PDF] Figures

On the Pathogenicity of Autoantigen-Specific T-Cell Receptors: Amanda R. Burton, Erica Vincent, Paula Y. Arnold, Greig P. Lennon, Matthew Smeltzer, Chin-Shang Li, Kathryn Haskins, John Hutton, Roland M. Tisch, Eli E. Sercarz, Pere Santamaria, Creg J. Workman, and Dario A.A. Vignali
Diabetes 2008 57: 1321 -1330. First published on February 25, 2008 as 10.2337/db07-1129 [Abstract] [Full Text] [PDF] Figures

Inhibition of Dipeptidyl Peptidase IV With Sitagliptin (MK0431) Prolongs Islet Graft Survival in Streptozotocin-Induced Diabetic Mice: Su-Jin Kim, Cuilan Nian, Doris J. Doudet, and Christopher H.S. McIntosh
Diabetes 2008 57: 1331 -1339. First published on February 25, 2008 as 10.2337/db07-1639 [Abstract] [Full Text] [PDF] Online-Only Appendix Figures

Pathophysiology:

Separate Impact of Obesity and Glucose Tolerance on the Incretin Effect in Normal Subjects and Type 2 Diabetic Patients: Elza Muscelli, Andrea Mari, Arturo Casolaro, Stefania Camastra, Giuseppe Seghieri, Amalia Gastaldelli, Jens J. Holst, and Ele Ferrannini
Diabetes 2008 57: 1340 -1348. First published on December 27, 2007 as 10.2337/db07-1315 [Abstract] [Full Text] [PDF]

Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients: Antonio Ceriello, Katherine Esposito, Ludovica Piconi, Michael A. Ihnat, Jessica E. Thorpe, Roberto Testa, Massimo Boemi, and Dario Giugliano
Diabetes 2008 57: 1349 -1354. First published on February 25, 2008 as 10.2337/db08-0063 [Abstract] [Full Text] [PDF]

Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis: Luca Valenti, Raffaela Rametta, Paola Dongiovanni, Marco Maggioni, Anna Ludovica Fracanzani, Marco Zappa, Enzo Lattuada, Giancarlo Roviaro, and Silvia Fargion
Diabetes 2008 57: 1355 -1362. First published on March 3, 2008 as 10.2337/db07-0714 [Abstract] [Full Text] [PDF]

Complications:

Increased GABAergic Tone in the Ventromedial Hypothalamus Contributes to Suppression of Counterregulatory Reponses After Antecedent Hypoglycemia: Owen Chan, Haiying Cheng, Raimund Herzog, Daniel Czyzyk, Wanling Zhu, Ajin Wang, Rory J. McCrimmon, Margretta R. Seashore, and Robert S. Sherwin
Diabetes 2008 57: 1363 -1370. First published on March 28, 2008 as 10.2337/db07-1559 [Abstract] [Full Text] [PDF] Figures

Ventromedial Hypothalamic Glucokinase Is an Important Mediator of the Counterregulatory Response to Insulin-Induced Hypoglycemia: Barry E. Levin, Thomas C. Becker, Jun-ichi Eiki, Bei B. Zhang, and Ambrose A. Dunn-Meynell
Diabetes 2008 57: 1371 -1379. First published on February 21, 2008 as 10.2337/db07-1755 [Abstract] [Full Text] [PDF]

The Locus for Hypoglycemic Detection Shifts With the Rate of Fall in Glycemia: The Role of Portal–Superior Mesenteric Vein Glucose Sensing: Maziyar Saberi, MaryAnn Bohland, and Casey M. Donovan
Diabetes 2008 57: 1380 -1386. First published on February 21, 2008 as 10.2337/db07-1528 [Abstract] [Full Text] [PDF]

5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy: Rose A. Gubitosi-Klug, Ramaprasad Talahalli, Yunpeng Du, Jerry L. Nadler, and Timothy S. Kern
Diabetes 2008 57: 1387 -1393. First published on March 17, 2008 as 10.2337/db07-1217 [Abstract] [Full Text] [PDF] Figures

Pharmacology and Therapeutics:

Selective Activation of Peroxisome Proliferator–Activated Receptor (PPAR) ${alpha}$ and PPAR ${gamma}$ Induces Neoangiogenesis Through a Vascular Endothelial Growth Factor–Dependent Mechanism: Federico Biscetti, Eleonora Gaetani, Andrea Flex, Tamar Aprahamian, Teresa Hopkins, Giuseppe Straface, Giovanni Pecorini, Egidio Stigliano, Roy C. Smith, Flavia Angelini, John J. Castellot, Jr., and Roberto Pola
Diabetes 2008 57: 1394 -1404. First published on February 11, 2008 as 10.2337/db07-0765 [Abstract] [Full Text] [PDF] Figures

Liver-Specific Peroxisome Proliferator–Activated Receptor ${alpha}$ Target Gene Regulation by the Angiotensin Type 1 Receptor Blocker Telmisartan: Markus Clemenz, Nikolaj Frost, Michael Schupp, Sandrine Caron, Anna Foryst-Ludwig, Christian Böhm, Martin Hartge, Ronald Gust, Bart Staels, Thomas Unger, and Ulrich Kintscher
Diabetes 2008 57: 1405 -1413. First published on January 9, 2008 as 10.2337/db07-0839 [Abstract] [Full Text] [PDF] Online-Only Appendix

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action: Nigel Turner, Jing-Ya Li, Alison Gosby, Sabrina W.C. To, Zhe Cheng, Hiroyuki Miyoshi, Makoto M. Taketo, Gregory J. Cooney, Edward W. Kraegen, David E. James, Li-Hong Hu, Jia Li, and Ji-Ming Ye
Diabetes 2008 57: 1414 -1418. First published on February 19, 2008 as 10.2337/db07-1552 [Abstract] [Full Text] [PDF] Online-Only Appendix

Genetics:

Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI: Rachel M. Freathy, Nicholas J. Timpson, Debbie A. Lawlor, Anneli Pouta, Yoav Ben-Shlomo, Aimo Ruokonen, Shah Ebrahim, Beverley Shields, Eleftheria Zeggini, Michael N. Weedon, Cecilia M. Lindgren, Hana Lango, David Melzer, Luigi Ferrucci, Giuseppe Paolisso, Matthew J. Neville, Fredrik Karpe, Colin N.A. Palmer, Andrew D. Morris, Paul Elliott, Marjo-Riitta Jarvelin, George Davey Smith, Mark I. McCarthy, Andrew T. Hattersley, and Timothy M. Frayling
Diabetes 2008 57: 1419 -1426. First published on March 17, 2008 as 10.2337/db07-1466 [Abstract] [Full Text] [PDF] Online-Only Appendix

AHSG Tag Single Nucleotide Polymorphisms Associate With Type 2 Diabetes and Dyslipidemia: Studies of Metabolic Traits in 7,683 White Danish Subjects: Gitte Andersen, Kristoffer Sølvsten Burgdorf, Thomas Sparsø, Knut Borch-Johnsen, Torben Jørgensen, Torben Hansen, and Oluf Pedersen
Diabetes 2008 57: 1427 -1432. First published on March 3, 2008 as 10.2337/db07-0558 [Abstract] [Full Text] [PDF] Online-Only Appendix

Genetic Similarities Between Latent Autoimmune Diabetes in Adults, Type 1 Diabetes, and Type 2 Diabetes: Camilla Cervin, Valeriya Lyssenko, Ekaterine Bakhtadze, Eero Lindholm, Peter Nilsson, Tiinamaija Tuomi, Corrado M. Cilio, and Leif Groop
Diabetes 2008 57: 1433 -1437. First published on February 29, 2008 as 10.2337/db07-0299 [Abstract] [Full Text] [PDF]

Online Letters to the Editor:

Comment on: Edghill et al. (2008) Insulin Mutation Screening in 1,044 Patients With Diabetes: Mutations in the INS Gene Are a Common Cause of Neonatal Diabetes but a Rare Cause of Diabetes Diagnosed in Childhood or Adulthood: Diabetes 57:1034–1042, 2008: Sten A. Ivarsson and Åke Lernmark
Diabetes 2008 57: e9 . [Extract] [Full Text] [PDF]

Comment on: DiChiara et al. (2007) The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Diabetes 56:3014–3019, 2007: Petra-Susanne Klein
Diabetes 2008 57: e10 . [Extract] [Full Text] [PDF]

Response to Comment on: DiChiara et al. (2007) The Effect of Aspirin Dosing on Platelet Function in Diabetic and Nondiabetic Patients: An Analysis From the Aspirin-Induced Platelet Effect (ASPECT) Study: Diabetes 56:3014–3019, 2007: Joseph DiChiara, Kevin P. Bliden, Udaya S. Tantry, Miruais S. Hamed, Mark J. Antonino, Thomas A. Suarez, Oscar Bailon, Anand Singla, and Paul A. Gurbel
Diabetes 2008 57: e11 . [Extract] [Full Text] [PDF]