Table 2

Lipid content of liver, plasma, and the subcutaneous adipose depot

Study AStudy B
ZDF controlsInsulinS597ZDF controlsInsulinS597
Liver
 TG (mg/liver)660 ± 100805 ± 115719 ± 126384 ± 35416 ± 43337 ± 32
 Palmitate (mg/liver)153 ± 15204 ± 9190 ± 27159 ± 9204 ± 9*177 ± 15
 Cholesterol (mg/liver)50.3 ± 2.953.6 ± 2.847.1 ± 4.363.7 ± 2.368.3 ± 3.757.9 ± 3.2
Plasma
 TG (mg/dL)541 ± 68637 ± 122275 ± 42*,††624 ± 58964 ± 54***462 ± 47†††
 Palmitate (mg/dL)12.4 ± 1.717.3 ± 3.47.1 ± 1.0††20.8 ± 1.734.0 ± 2.8***19.6 ± 1.9†††
 FFA (mg/dL)N/AN/AN/A6.41 ± 1.193.40 ± 0.282.22 ± 0.26*
 Cholesterol (mg/dL)177 ± 4199 ± 8*225 ± 5***,146 ± 7132 ± 4147 ± 7
Subcutaneous adipose depot
 TG (g/depot)N/AN/AN/A31.9 ± 3.040.1 ± 5.2**39.7 ± 4.5**
 Palmitate (g/depot)N/AN/AN/A2.27 ± 0.202.60 ± 0.382.56 ± 0.33
  • TG, palmitate, and cholesterol were all quantified in the liver. TG, palmitate, FFA, and cholesterol were quantified in plasma. Palmitate was quantified and TG content was estimated based on fat pad mass in the subcutaneous adipose depot. Values are expressed as mean ± SEM. N/A, not available.

  • *P < 0.05 as compared with ZDF controls (one-way ANOVA with Bonferroni posttests).

  • **P < 0.01 as compared with ZDF controls (one-way ANOVA with Bonferroni posttests).

  • ***P < 0.001 as compared with ZDF controls (one-way ANOVA with Bonferroni posttests).

  • P < 0.05 as compared with insulin (one-way ANOVA with Bonferroni posttests).

  • ††P < 0.01 as compared with insulin (one-way ANOVA with Bonferroni posttests).

  • †††P < 0.001 as compared with insulin (one-way ANOVA with Bonferroni posttests).