Table 1

Animal, liver, and plasma characteristics

CDCD-MKWDWD-MK
Body weight (g)27.5 ± 0.627.7 ± 0.739.0 ± 1.4*37.2 ± 1.4*
Liver weight (g)1.14 ± 0.041.02 ± 0.05#1.46 ± 0.08*1.16 ± 0.04*#
Fat pad mass (g)0.76 ± 0.090.84 ± 0.112.80 ± 0.14*2.52 ± 0.21*
Body fat (%)14.5 ± 2.217.7 ± 0.635.1 ± 0.8*36.7 ± 1.7*
Food intake (kcal/week)84.0 ± 3.481.7 ± 4.989.7 ± 3.6*95.2 ± 5.1*
Plasma ALT (units/L)12.3 ± 1.014.2 ± 0.822.4 ± 2.8*18.3 ± 1.9*
Plasma total cholesterol (mg/dL)112.9 ± 7.4111.9 ± 7.0137.7 ± 8.1*126.1 ± 7.8*
Plasma triglycerides (mg/dL)54.1 ± 3.159.6 ± 4.4#61.1 ± 5.367.9 ± 3.8#
Plasma NEFA (nmol/L)0.70 ± 0.060.70 ± 0.080.83 ± 0.080.76 ± 0.07
Plasma uric acid (mg/dL)0.45 ± 0.040.40 ± 0.03#0.72 ± 0.08*0.49 ± 0.04*#
Liver DPP-4 activity (RLUs)28,391 ± 1,5519,729 ± 1,362#27,567 ± 1,9317,336 ± 679#
  • Values are means ± SE. n = 8–12 per group except n = 6–7 per group for percent body fat and n = 6–8 per group for food intake. Fat pad mass is the sum of epididymal and retroperitoneal fat pads. RLUs, relative light units.

  • *P < 0.05, main effect of diet.

  • #P < 0.05, main effect of MK compound.