TABLE 2

Comparison of ORs for TCF7L2 SNPs genotyped in Finnish and in Icelandic, Danish, and American (U.S.) samples

SNPTCF7L2 locationGenomic position§Relative positionRisk alleleFinnish sample (current study)Combined Icelandic, Danish, and American (U.S.) samples*Test for heterogeneity of OR between four samples
OR95% CITwo-sided P valueOR¶95% CITwo-sided P valueP value
rs11196175Intron 3114726604−72.288C1.160.59–1.350.070
rs7079711Intron 3114735778−63.114G1.080.93–1.260.30
rs11196181Intron 3114739008−59.884G1.010.81–1.260.94
rs17747324Intron 3114742493−56.399C1.261.07–1.480.0054
rs7901695Intron 3114744078−54.814C1.251.07–1.450.00421.491.35–1.653.9 × 10−150.21
rs7903146Intron 3114748339−50.553T1.331.14–1.560.000421.541.39–1.702.1 × 10−170.29
rs7896811Intron 3114756707−42.185C1.010.86–1.180.93
rs11196192Intron 3114772277−26.615G1.350.97–1.870.080
rs11196199Intron 3114786107−12.785A1.040.89–1.210.65
rs17685538Intron 3114787461−11.431C1.140.96–1.360.14
rs7895340Intron 4114791515−7.377A1.161.02–1.320.0291.311.19–1.441.4 × 10−80.45
rs11196205Intron 4114797037−1.855C1.151.01–1.310.0301.311.19–1.444.6 × 10−80.41
rs12255372Intron 41147988920T1.361.15–1.610.000261.521.38–1.682.5 × 10−160.41
rs11196213Intron 411481154412.652T1.141.00–1.290.049
rs11196228Intron 411485428755.395T1.391.07–1.810.015
rs290494Intron 411487586176.969G1.140.94–1.370.18
rs1555485Intron 4114902524103.632C1.020.88–1.180.82
  • * From Grant et al. (2); see online appendix Table 4.

  • Test for OR heterogeneity between the individual Finnish, Icelandic, Danish, and American (U.S.) samples.

  • Intronic location from Ensemble ENST00000347863.

  • § Genomic position on chromosome 10 in NCBI Build 35.

  • Genomic position (in kilobytes) relative to rs12255372.

  • OR calculated using an additive genetic model that in logistic regression is multiplicative on the OR scale.