TABLE 2

Univariate Cox proportional hazard analysis: time to menopause

Risk factorHRP95% Cl
Type 1 diabetes1.990.04(1.02–3.88)
Hashimoto’s thyroiditis1.340.33(0.75–2.41)
Any autoimmune disease*1.260.44(0.71–2.24)
Age at menarche1.110.29(0.92–1.31)
Menstrual irregularities <30 years of age1.870.04(1.04–3.35)
Nulliparous2.140.01(1.20–3.84)
OC use0.720.27(0.41–1.28)
Unilateral oophorectomy6.51<0.0001(2.84–14.9)
DQA1*0301-DQB1*03021.850.04(1.02–3.35)
DQA1*0501-DQB1*02010.740.33(0.40–1.37)
Family history of early menopause2.120.14(0.78–5.73)
Ever smoked1.230.48(0.69–2.17)
Duration smoking ≥1 pack/week1.000.91(0.98–1.02)
Alcohol consumption (drinks/week)0.960.34(0.87–1.05)
BMI1.010.82(0.95–1.07)
College attendance1.270.46(0.67–2.43)
Income >$40,000/year0.900.34(0.72–1.12)
  • *

    * Hashimoto’s thyroiditis, Graves’ disease, rheumatoid arthritis.