TABLE 2

Plasma parameters immediately before (Preclamp) and during insulin stimulation (Clamp) in the euglycemic-hyperinsulinemic clamp performed on standard diet-fed (CH-Con) or high-fat-fed rats 24 h after AICAR (HF-AIC) or saline (HF-Con) injection

CH-Con
HF-Con
HF-AIC
PreclampClampPreclampClampPreclampClamp
Glucose (mmol/l)7.9 ± 0.37.9 ± 0.19.5 ± 0.37.6 ± 0.28.4 ± 0.2§7.5 ± 0.2
Insulin (mU/l)38 ± 5108 ± 963 ± 7*131 ± 1453 ± 5127 ± 8
Fatty acids (mmol/l)0.60 ± 0.060.43 ± 0.060.36 ± 0.04*0.37 ± 0.050.48 ± 0.050.32 ± 0.03
Triglycerides (mmol/l)0.97 ± 0.160.40 ± 0.110.49 ± 0.050.15 ± 0.040.41 ± 0.040.14 ± 0.03
Glycerol (mmol/l)0.15 ± 0.040.24 ± 0.040.10 ± 0.020.18 ± 0.040.14 ± 0.010.15 ± 0.01
  • Data are means ± SE. n = 6–12 per group.

  • *

    * P < 0.05,

  • P < 0.01,

  • P < 0.001 vs. CH-Con preclamp;

  • §

    § P < 0.05 vs. HF-Con pre-clamp;

  • P < 0.05 vs. CH-Con clamp.