TABLE 4

Effects of AICAR administration on in vivo insulin action in standard diet-fed rats

CH-Con2CH-AICP
GIR (mg · kg−1 · min−1)32.0 ± 1.437.6 ± 3.4NS
Rd (mg · kg−1 · min−1)30.4 ± 1.437.6 ± 2.9<0.05
HGO (mg · kg−1 · min−1)−1.6 ± 0.10.0 ± 1.3NS
Red muscle Rg′ (μmol · 100g−1 · min−1)33.8 ± 3.841.8 ± 7.3NS
White muscle Rg′ (μmol · 100g−1 · min−1)5.9 ± 0.513.4 ± 2.4<0.05
  • Data are means ± SE. Responses determined during euglycemic-hyperinsulinemic clamps performed on standard diet-fed rats 24 h after AICAR (CH-AIC) or saline (CH-Con2) injection (n ≥ 7 per group).