TABLE 2

Metabolic characteristics of aging rats


young
SO
SC
VF
CR
n66868
Glucose (mmol/l)
 Basal7.2 ± 0.27.6 ± 0.57.4 ± 0.77.7 ± 0.37.2 ± 0.7
 Clamp7.3 ± 0.37.5 ± 0.37.5 ± 0.47.6 ± 0.37.3 ± 0.7
Insulin (μU/ml)
 Basal14 ± 229.5 ± 3.5*25 ± 2*18 ± 215 ± 2
 Clamp98 ± 1396 ± 10102 ± 11102 ± 2292 ± 18
FFA (mmol/l)
 Basal0.99 ± 0.151.1 ± 0.240.81 ± 0.141.06 ± 0.141.11 ± 0.11
 Clamp0.21 ± 0.080.35 ± 0.10.23 ± 0.10.27 ± 0.040.32 ± 0.03
Ra (mg · kg−1 · min−1)
 Basal12.1 ± 0.49.1 ± 0.3*8.7 ± 0.2*10.7 ± 0.311.0 ± 0.8
GIR (mg · kg−1 · min−1)
 Clamp21.3 ± 3.08.4 ± 4.2*10.4 ± 3.2*18.0 ± 2.021.8 ± 4.6
Gly (mg · kg−1 · min−1)
 Basal7.1 ± 0.66.0 ± 0.26.4 ± 0.56.2 ± 0.37.4 ± 0.7
 Clamp14.4 ± 1.56.9 ± 0.4*8.6 ± 1.4*14.7 ± 2.113.7 ± 2.0
GS (mg · kg−1 · min−1)
 Basal5.0 ± 0.73.1 ± 0.1*2.3 ± 0.5*4.4 ± 0.33.6 ± 0.3
 Clamp12.6 ± 1.45.1 ± 0.7*6.5 ± 0.6*9.3 ± 0.910.4 ± 2.4
  • Plasma glucose, insulin, FFA concentrations, basal rate of EGP (Ra), glucose infusion rate (GIR), glycolysis (Gly), and glycogen synthesis (GS) during the basal period and during the pancreatic (euglycemic) clamp are shown. These parameters were measured at basal conditions and during the insulin clamps (see group description in research design and methods).

  • *

    * P < 0.001 vs. young, VF, and CR. All data are presented as means ± SE.