TABLE 2

Body composition as measured by DEXA and abdominal MRI, with fasting serum lipids and leptin

LipodystrophyControlP value*
Whole-body DEXA
 Fat-free mass (kg)58.62 ± 2.5457.54 ± 1.230.71
 Total body fat (kg)14.27 ± 2.5419.83 ± 3.640.23
 Body fat (%)18.8 ± 2.724.3 ± 9.30.18
 Trunk fat (kg)9.23 ± 1.759.97 ± 2.040.79
 Central abdominal fat (kg)1.41 ± 0.241.34 ± 0.260.85
 Central abdominal fat (% of total body fat)9.9 ± 0.56.7 ± 0.3< 0.0001
 Limb fat (kg)4.24 ± 0.759.01 ± 1.630.02
 Limb fat (% of total body fat)29.9 ± 1.945.9 ± 2.1< 0.0001
Abdominal MRI scans
 TAT (l)2.75 ± 0.462.77 ± 0.590.98
 VAT (l)1.49 ± 0.291.00 ± 0.200.18
 SAT (l)1.26 ± 0.221.77 ± 0.430.31
 VAT as % of TAT52.7 ± 3.637.0 ± 2.60.002
 VAT:SAT ratio1.25 ± 0.210.61 ± 0.080.01
Serum lipids and leptin
 Total cholesterol (mmol/l)4.8 ± 0.34.3 ± 0.30.32
 HDL cholesterol (mmol/l)0.86 ± 0.051.07 ± 0.070.03
 Triglycerides (mmol/l)2.9 ± 0.51.6 ± 0.50.03†
 Free fatty acids (mmol/l)0.44 ± 0.050.35 ± 0.050.24
 Apolipoprotein B (g/l)1.11 ± 0.080.89 ± 0.060.03
 Leptin (ng/ml)2.8 ± 0.74.5 ± 1.60.30
 Leptin (ng · ml−1 · kg−1 total body fat)0.21 ± 0.030.19 ± 0.020.48
  • Values are mean ± SE.

  • * P values were calculated by a two-tailed t test.

  • Logarithmic transformation applied to serum triglycerides for statistical analyses.