TABLE 1

FOXC2 C-512T genotype-discordant sibling pair analysis identifies the T allele as a potential genetic factor protecting against insulin resistance

Sibling 1
vs.Sibling 2
OSDP
CCCT
CCvs.TT
CTvs.TT
Female pairs (n)8282
 Age (years)50.1 ± 1.749.5 ± 1.846.60.1
 BMI (kg/m2)25.0 ± 0.424.9 ± 0.410.80.7
 HOMA-IR1.99 (1.32–2.82)1.66 (1.08–2.49)390.007
 fP-Triglycerides (mmol/l)1.18 (0.85–1.70)1.05 (0.90–1.28)16.40.007
Male pairs (n)8787
 Age (years)45.3 ± 1.645.1 ± 1.625.30.4
 BMI (kg/m2)25.7 (24.0–27.2)25.2 (23.8–27.2)3.820.9
 HOMA-IR1.80 (1.40–2.72)2.10 (1.51–2.67)20.9
 fP-Triglycerides (mmol/l)1.16 (0.85–1.57)1.23 (0.92–1.64)−20.90.2
All pairs (n)169169
 Age (years)47.2 (36.0–60.0)44.6 (35.1–60.2)71.80.07
 BMI (kg/m2)25.4 (23.5–27.2)25.1 (23.3–27.3)14.60.8
 HOMA-IR1.94 (1.35–2.76)1.86 (1.23–2.50)410.052
 fP-Triglycerides (mmol/l)1.16 (0.85–1.62)1.14 (0.9–1.47)−4.50.9
  • Data are means ± SE or median (interquartile range).