TABLE 4

Risk of incident dementia associated with diabetes and APOE ε4: the HAAS

UnadjustedAdjusted*Adjusted
Total dementia
 Diabetes only1.3 (0.9–2.0)1.2 (0.8–1.9)1.4 (0.9–2.2)
 APOE ε4 only1.4 (0.8–2.4)1.6 (0.9–2.7)1.4 (0.8–2.5)
 Diabetes/ε41.9 (1.1–3.6)2.3 (1.2–4.4)2.6 (1.3–5.1)
 ε4 × diabetes interaction term P > 0.2
VsD
 Diabetes only1.6 (0.7–3.5)2.0 (0.8–4.7)1.9 (0.8–4.6)
 APOE ε4 only0.7 (0.2–2.9)0.8 (0.2–3.6)0.7 (0.1–3.1)
 Diabetes/ε42.6 (0.8–7.9)3.7 (1.1–12.5)2.8 (0.8–9.8)
 ε4 × diabetes interaction term P > 0.2
AD§
 Diabetes only1.5 (0.9–2.6)1.4 (0.8–2.4)1.6 (0.9–2.8)
 APOE ε4 only1.9 (0.9–3.7)2.1 (1.1–4.3)2.0 (0.9–4.0)
 Diabetes/ε42.7 (1.3–5.8)3.4 (1.5–7.5)4.4 (1.9–10.0)
 ε4 × diabetes interaction term P > 0.2
AD without CVD
 Diabetes only1.0 (0.5–2.1)1.0 (0.5–2.0)1.1 (0.5–2.4)
 APOE ε4 only1.7 (0.8–3.9)2.0 (0.9–4.6)1.7 (0.7–4.2)
 Diabetes/ε43.3 (1.5–7.6)4.2 (1.8–9.9)5.5 (2.2–13.7)
 ε4 × diabetes interaction term P = 0.114
  • Data are RR (95% CI). Participants with no diabetes and no ε4 served as the reference group to calculate RR and 95% CI.

  • *

    * Adjusted for age, education, smoking status, and alcohol use;

  • adjusted for age, education, smoking status, alcohol, midlife cholesterol, systolic blood pressure, BMI, ABI, stroke, and CHD;

  • ε4 × diabetes interaction term represents the cross-product between ε4 and diabetes, the analysis was adjusted as in the model in the † footnote;

  • §

    § AD definition includes subjects with concomitant CVD contribution to dementia.