TABLE 5

Regression analysis of diabetes and APOE ε4 status on infarcts, NP, NFT, and CAA

Diabetes onlyAPOE ε4 onlyDiabetes/APOE ε4
Lacune*1.0 (0.6–1.8)0.9 (0.4–1.9)1.5 (0.8–3.5)
Large infarct*1.8 (1.1–3.0)1.6 (0.7–3.6)1.2 (0.5–3.2)
NP (cortex)*0.8 (0.5–1.4)1.1 (0.6–2.3)1.5 (0.7–3.1)
NP (hippocampus)*1.2 (0.5–2.3)2.0 (0.6–6.6)3.0 (1.2–7.6)
NFT (cortex)1.0 (0.6–2.4)2.9 (1.1–7.8)3.5 (1.6–7.5)
NFT (hippocampus)*1.0 (0.6–1.4)1.7 (1.1–2.8)2.4 (1.5–3.7)
CAA0.6 (0.3–1.2)3.6 (1.0–10.6)6.6 (1.5–29.6)
  • Data are IRR (95% CI) or RR (95% CI). Participants with no diabetes and no ε4 served as the reference group to calculate RR and 95% CI. Analyses were adjusted for age at exam 4, interval between exam 4 and death, education, smoking status, alcohol, midlife cholesterol and systolic blood pressure, BMI, and ABI.

  • *

    * Poisson regression, IRR,

  • logistic regression, RR.