TABLE 3

Additional genes altered in type 2 diabetes (D2− and D2+)

Probe setFold Δ
Gene nameClass/function
AB
HG2239-HT2324↑11*(↑1.3)Potassium channel proteinIon channel
U90546↑5.8*(↑1.7)Butyrophilin 4Immune system
X89267↑3.6*(↑1.5)Uroporphyrinogen decarboxylaseHeme biosynthesis
L24564↑3.2(↑1.8)RadRas-oncogene associated with diabetes
D43951↑3.1§(↑1.3)KIAA0099Unknown
D79986↑2.3§(↑1.3)KIAA0164Unknown
J02611↑2.1(↑1.8)Apolipoprotein DLipid transport
L11238↓3.2§(↓1.6)Platelet membrane glycoprotein VHomeostasis
X59405↓3.0(↓1.5)Membrane cofactor proteinRegulatory glycoprotein
X63575↓2.8(↓1.5)Calcium ATPaseCalcium homeostasis
M16714↓2.6§(↓1.6)MHC I lymphocyte antigenImmune system
X00371↓2.5*(↓1.8)MyoglobinOxygen transport
X91103↓2.5§(↓1.2)Hr44Immune system
X01060↓2.4(↓1.6)Transferrin receptorIron uptake
U90313↓2.3§(↓1.4)Glutathione-S-transferaseGlutathione metabolism
X75755↓2.3(↓1.3)PR264Unknown
U33286↓2.2§(↓1.2)Chromosome segregation gene CASCell proliferation/apoptosis
X15729↓2.1§(↓1.5)Nuclear p68 proteinCell poliferation
X06700↓2.1§(↓1.7)Pro-α (III) collagenExtracellular matrix protein
AB000220↓1.9*(↓1.4)Semaphorin EImmune system
  • A, control versus D2− patients; B, control versus D2+ patients.

  • *

    * P < 0.05,

  • P > 0.05,

  • P < 0.001,

  • §

    § P < 0.01,

  • P < 0.0001, with P values calculated from t test on the average difference between control subjects and D2− (A) or D2+ (B) patients.