TABLE 2

Glucose and insulin metabolism measured using euglycemic-hyperinsulinemic clamps and fasting glucose and insulin levels in women pregravid and during both early and late pregnancy

PregravidEarly pregnancyLate pregnancy
ISCLAMP (10−2 mg · kg−1 FFM · min−1/μU · ml−1)
 Lean NGT14.3 ± 1.317.4 ± 1.29.9 ± 0.5*
 Obese NGT14.2 ± 1.915.4 ± 3.19.5 ± 1.5*
 Obese GDM8.8 ± 2.59.8 ± 2.04.9 ± 0.8*
Fasting glucose (mg/dl)
 Lean NGT90.4 ± 2.083.6 ± 1.2*81.0 ± 0.9*
 Obese NGT93.2 ± 1.786.8 ± 1.881.0 ± 1.9*
 Obese GDM98.0 ± 1.887.4 ± 2.988.6 ± 4.5*
Fasting insulin (μU/ml)
 Lean NGT8.2 ± 0.96.1 ± 0.610.7 ± 0.9*
 Obese NGT9.0 ± 1.69.2 ± 3.011.9 ± 2.7*
 Obese GDM18.9 ± 4.116.8 ± 5.827.5 ± 5.6*
  • Data are means ± SE; n = 5 per group. IS, insulin sensitivity derived from euglycemic-hyperinsulinemic clamp studies.

  • *

    * Significantly different from pregravid, P < 0.001.

  • Significantly different from lean NGT group, P < 0.05.