TABLE 1

Clinical and metabolic characteristics of lean, obese, and diabetic subjects

LeanObeseDiabetic
Age (years)45 ± 546 ± 350 ± 2
BMI (kg/m2)24.4 ± 0.633.4 ± 1.4*34.7 ± 1.1*
HbA1c (%)5.1 ± 0.25.2 ± 0.210.1 ± 1.2*
Glucose (mmol/l)4.8 ± 0.15.1 ± 0.19.4 ± 0.8*
Insulin (pmol/l)49 ± 1086 ± 21142 ± 22.8
Clamp insulin (pmol/l)6,400 ± 6006,108 ± 9604,012 ± 696§
Free fatty acids (mmol/l)0.36 ± 0.060.53 ± 0.070.80 ± 0.10*
GDR (mg · kg−1 · min−1)13.2 ± 0.99.8 ± 0.4*5.0 ± 0.4*
  • Data are means ± SD. The study comprised 15 lean (all male), 16 obese (all male), and 21 obese type 2 diabetic (18 male and 3 female) subjects. Glucose, insulin, and free fatty acids were measured after an overnight fast.

  • *

    * P < 0.001 vs. lean;

  • P < 0.001 vs. obese;

  • P < 0.01 vs. lean;

  • §

    § P < 0.05 vs. lean;

  • P < 0.05 vs. obese.