TABLE 2

Plasma insulin and FFA concentrations during euglycemic-hyperinsulinemic clamps

Time (min)
−30−20−100102030405060
Plasma insulin (μU/ml)
 Lean4 ± 14 ± 14 ± 14 ± 157 ± 347 ± 247 ± 248 ± 247 ± 353 ± 4
 Obese9 ± 1*8 ± 1*9 ± 1*9 ± 1*77 ± 6*70 ± 4*65 ± 4*60 ± 4*64 ± 5*69 ± 4*
Plasma FFAs (mmol/l)
 Lean0.65 ± .070.63 ± .070.59 ± 0.060.61 ± 0.070.59 ± 0.060.36 ± 0.040.23 ± 0.020.17 ± 0.040.16 ± 0.040.14 ± 0.04
 Obese0.88 ± 0.66*0.88 ± 0.07*0.85 ± 0.07*0.86 ± 0.07*0.79 ± 0.08*0.68 ± 0.07*0.49 ± 0.06*0.50 ± 0.09*0.50 ± 0.10*0.50 ± 0.10*
  • Data are means ± SE. Plasma insulin and FFA concentrations achieved during euglycemic clamps are shown.

  • *

    * P < 0.01 vs. lean subjects.