TABLE 3

Muscle ceramide concentrations

nCeramide
C16C16 DHCC18C20C22C24:1C24:0Total
Lean
 Basal82.07 ± 0.261.27 ± 0.367.81 ± 0.840.23 ± 0.082.95 ± 0.365.06 ± 0.585.7 ± 0.5825.1 ± 2.1
 30 min32.66 ± 0.904.59 ± 2.157.84 ± 0.380.91 ± 0.214.64 ± 0.656.03 ± 1.056.03 ± 1.0529.3 ± 4.2
 45–60 min81.51 ± 0.181.16 ± 0.227.74 ± 1.940.28 ± 0.102.51 ± 0.484.81 ± 0.824.94 ± 1.0922.9 ± 4.6
Obese
 Basal98.53 ± 4.71*3.03 ± 1.45*12.8 ± 1.85*1.39 ± 0.72*4.71 ± 0.66*7.79 ± 0.95*8.02 ± 0.93*46.3 ± 8.8*
 30 min63.02 ± 1.071.29 ± 0.3510.98 ± 1.470.90 ± 0.374.21 ± 0.636.69 ± 0.728.79 ± 2.1635.9 ± 5.6
 45–60 min72.17 ± 0.611.35 ± 0.448.64 ± 1.970.37 ± 0.113.78 ± 0.816.34 ± 1.906.52 ± 1.5329.2 ± 5.8
  • Data are means ± SE. Ceramide content of biopsies of vastus lateralis muscle was assayed as described in the text. Units are given in picomoles per 2 mg muscle.

  • *

    * P < 0.05 vs. lean control subjects.