TABLE 3

Morphometric data on ganglion cells

GroupnCell area (μm2)Nuclear area (μm2)Nuclear area–to–cellular area ratio (%)Density (n/mm2)
Lm7656.0 ± 33.9102.1 ± 3.917.6 ± 0.62,685 ± 264
Tg8608.3 ± 23.4104.0 ± 4.219.3 ± 0.32,716 ± 122
LmDM8651.5 ± 26.8105.3 ± 3.518.4 ± 0.52,604 ± 87
TgDM6469.8 ± 43.9*86.4 ± 4.4*20.9 ± 1.02,838 ± 198
LmDM+ARI9623.4 ± 44.899.7 ± 4.418.8 ± 0.62,826 ± 111
TgDM+ARI8583.3 ± 31.598.9 ± 4.119.0 ± 0.63,167 ± 220
  • Data are means ± SE. Lm, littermate control mice; Tg, mice transgenic for human aldose reductase; LmDM, diabetic littermate mice; TgDM, diabetic transgenic mice; LmDM+ARI, diabetic littermate mice treated with ARI; TgDM+ARI, diabetic transgenic mice treated with ARI.

  • *

    * P < 0.05 vs. littermate mice, transgenic mice, diabetic littermate mice, diabetic littermate mice treated with ARI, and diabetic transgenic mice treated with ARI;

  • P < 0.05 vs. littermate mice, diabetic littermate mice, diabetic littermate mice treated with ARI, and diabetic transgenic mice treated with ARI.