TABLE 1

Characteristics of the study cohort examined by a hyperglycemic clamp

nBMI (kg/m2)Fasting glucose (mmol/l)HbA1c (%)First-phase insulin (pmol/l)*Second-phase insulin (pmol/l)
Noncarriers9028.46.565.7694312
A3243G carriers224.76.355.9390141
  • *

    * First-phase integrated insulin concentrations at 2.5, 5, 7, and 10 min after application of 10 mmol/l hyperglycemia.

  • Second-phase average insulin concentration in the 120- to 180-min range, minus basal.