TABLE 2

Association of SNPs in ACDC with diabetes, BMI, and other metabolic variables

SNPGenotypeAsssociation with type 2 diabetes
Association with BMI
Association with serum adiponectin
Diabetes n (%)Odds ratio (95% CI)Pμ (kg/m2)*β (95% CI)Pm (mg/ml)*β (95% CI)P
-12823GG601 (60.7)572 (35.3)316 (4.54)
GA412 (55.6)398 (36.0)240 (5.04)
AA43 (58.1)1.19 (0.94–1.52)0.1541 (35.8)0.00 (−0.02 to 0.02)0.9426 (5.64)−0.11 (−0.18 to −0.04)0.002
-11365GG279 (62.4)273 (35.0)156 (4.93)
GC520 (56.4)501 (35.9)300 (4.86)
CC188 (65.4)0.91 (0.74–1.13)0.41176 (35.8)−0.01 (−0.03 to 0.01)0.3186 (4.29)0.06 (−0.01 to 0.12)0.07
45TT846 (58.3)808 (35.6)462 (4.78)
TG177 (61.0)171 (36.0)100 (4.76)
GG5 (40.0)0.90 (0.63–1.30)0.595 (29.3)0.00 (−0.04 to 0.05)0.903 (6.45)−0.01 (−0.11 to 0.09)0.85
276CC620 (59.8)595 (35.7)331 (4.83)
CT333 (60.1)318 (35.3)179 (4.67)
TT50 (52.0)1.09 (0.85–1.40)0.5246 (34.6)0.00 (−0.02 to 0.03)0.7928 (4.67)0.04 (−0.03 to 0.11)0.29
3286CC505 (58.2)485 (35.7)273 (4.93)
CT459 (60.4)438 (35.5)255 (4.71)
TT94 (51.1)1.05 (0.83–1.32)0.6990 (35.0)0.00 (−0.03 to 0.02)0.8554 (4.64)0.04 (−0.02 to 0.10)0.15
SNPGenotypeAssociation with HDL cholesterol
Association with ISI
Association with CIR
μ (mM)β (95% CI)Pμ (SD)β (95% CI)Pμ (SD)β (95% CI)P
-12823GG116 (1.19)351 (0.03)281 (0.06)
GA87 (1.17)263 (−0.03)222 (0.07)
AA12 (1.16)0.04 (−0.04 to 0.11)0.3328 (0.17)0.03 (−0.10 to 0.16)0.1626 (0.19)−0.13 (−0.28 to 0.01)0.07
-11365GG60 (1.16)168 (−0.01)142 (0.01)
GC106 (1.18)324 (0.01)276 (0.01)
CC26 (1.33)−0.08 (−0.15 to −0.01)0.03100 (0.04)0.00 (−0.12 to 0.12)0.9774 (0.02)0.00 (−0.16 to 0.15)0.96
45TT168 (1.19)515 (0.01)424 (0.04)
TG40 (1.15)108 (−0.01)92 (−0.10)
GG2 (1.20)0.03 (−0.07 to 0.13)0.602 (0.37)0.03 (−0.17 to 0.22)0.8000.09 (−0.15 to 0.34)0.45
276CC123 (1.17)372 (0.02)307 (0.05)
CT67 (1.18)194 (−0.03)159 (−0.03)
TT8 (1.37)−0.04 (−0.13 to 0.05)0.3630 (0.11)0.02 (−0.12 to 0.16)0.8324 (−0.20)0.10 (−0.06 to 0.26)0.21
3286CC102 (1.16)311 (0.02)256 (0.06)
CT92 (1.14)274 (−0.01)226 (0.07)
TT21 (1.17)−0.01 (−0.08 to 0.05)0.7057 (0.00)0.02 (−0.09 to 0.14)0.7046 (−0.29)0.13 (−0.01 to 0.28)0.07
SNPGenotypeAssociation with triglycerides
Association with insulin secretion
Association with insulin sensitivity
m (mM)*β (95% CI)Pm (pmol/l)*β (95% CI)Pm (mg · kg−1 · min−1)*β (95% CI)P
-12823GG113 (1.30)124 (1,115)181 (3.58)
GA82 (1.25)82 (1,300)130 (3.53)
AA11 (1.25)0.03 (−0.09 to 0.15)0.637 (1,250)−0.05 (−0.27 to 0.17)0.6610 (3.46)−0.01 (−0.08 to 0.06)0.85
-11365GG57 (1.32)36 (1,480)63 (3.54)
GC100 (1.25)115 (1,200)166 (3.54)
CC26 (1.11)0.08 (−0.04 to 0.19)0.1939 (1,025)0.10 (−0.05 to 0.24)0.1960 (3.62)−0.01 (−0.07 to 0.04)0.61
45TT160 (1.25)174 (1,150)266 (3.56)
TG39 (1.43)28 (1,375)40 (3.42)
GG2 (1.25)−0.09 (−0.25 to 0.07)0.283 (1,535)−0.12 (−0.33 to 0.09)0.273 (5.22)−0.02 (−0.13 to 0.08)0.66
276CC118 (1.32)130 (1,235)188 (3.56)
CA63 (1.17)58 (1,150)96 (3.48)
AA9 (1.83)−0.01 (−0.16 to 0.13)0.8710 (1,020)0.03 (−0.12 to 0.18)0.6619 (3.48)0.04 (−0.03 to 0.11)0.24
3286CC96 (1.28)109 (1,175)159 (3.56)
CT87 (1.17)90 (1,160)138 (3.53)
TT22 (1.66)−0.05 (−0.15 to 0.05)0.3415 (1,265)−0.04 (−0.18 to 0.11)0.6225 (3.60)0.01 (−0.06 to 0.07)0.84
  • Odds ratios for diabetes and differences (β) between genotypes (GT) for continuous variables are adjusted for age, sex, ethnicity, and birth year in generalized estimating equation models that allow for the effect of sibship. Odds ratios or differences are analyzed under an additive model and are expressed per copy of the more common allele (the allele listed first). Means (μ) for continuous variables are adjusted for age and sex.

  • *

    * Represents geometric mean.

  • Difference (β) is expressed in terms of the natural logarithm of the relevant variable. Analysis of insulin secretion is restricted to those with normal glucose tolerance.