TABLE 3

Tissue specificity of the monoclonal antibodies produced by the 22 pancreas negative antibody–secreting hybridomas in several NOD.RAG-2−/− mouse organs

HybridomaIsotypeSourceParotidMixed salivary glandBronchial glandThyroidBrainStomachKidney
221BIgM κNOD+++
285IgG1 κNOD
279IgM κNOD
253IgG1 κNOD
243IgM κNOD
221IgM κNOD
212IgM κNOD
56IgG1 κ8.3-NOD
112IgM κ8.3-NOD+
74IgG1 κ8.3-NOD+
98IgM κ8.3-NOD
147IgM κ8.3-NOD
156IgG1 κ8.3-NOD
205IgM κ8.3-F1
270IgG1 κ8.3-F1
117IgM κ8.3-F1
192IgM κ(NODXNOR)F1
298IgG1 κ(NODXNOR)F1
183-39IgM κ(NODXNOR)F1++
171DIgM κ(NODXNOR)F1++++
172BIgM κ(NODXNOR)F1+
84CIgM κ(NODXNOR)F1++