TABLE 2

mRNA expression in skeletal muscle posttreatment

MetforminRosiglitazonePlaceboP value
n91010
Lipid transport and metabolism
    CD361060 ± 1861027 ± 1331000 ± 161NS
    FAT410.5 ± 2.310.5 ± 2.312.3 ± 4.4NS
    ACC-α2.7 ± 0.63.3 ± 0.63.4 ± 0.9NS
    ACC-β61 ± 1365 ± 1368 ± 12NS
    LPL104 ± 25253 ± 88144 ± 28NS
    SCD0.7 ± 0.31.4 ± 0.40.9 ± 0.2NS
    UCP3420 ± 87285 ± 46480 ± 114NS
    DGK δ36 ± 1030 ± 438 ± 14NS
Glucose transport and metabolism
    GLUT4145 ± 40151 ± 35193 ± 47NS
    Hexokinase 225 ± 1128 ± 922 ± 8NS
    CAP265 ± 40281 ± 39224 ± 33NS
    Adiponectin receptor 1322 ± 49277 ± 42244 ± 40NS
Transcription factors
    PPAR-γ3.4 ± 0.84.2 ± 0.65.1 ± 2.0NS
    PGC1-α148 ± 16169 ± 29126 ± 15NS
    PGC1-β11.8 ± 2.214.4 ± 2.917.6 ± 5.6NS
    PRC7.3 ± 1.67.3 ± 1.67.6 ± 1.9NS
    NRF-152 ± 1447 ± 870 ± 33NS
    FOXO1A30 ± 524 ± 328 ± 3NS
    SREBP133.6 ± 7.727.7 ± 4.232.3 ± 8.8NS
  • Data are mean ± SE arbitrary units normalized to GAPDH.