TABLE 1

Baseline characteristics stratified by peak response curve morphology group

VariableGroup 1: normal peakGroup 2: early nondominant peakGroup 3: early dominant peakP for trend
n1379341
Sex (% male)4340640.06
Age (years)53 ± 7.855 ± 7.055 ± 8.50.053
Ethnicity (% European)5544510.2
Blood pressure measures
    Resting brachial systolic (mmHg)133 ± 20142 ± 24146 ± 260.001
    Resting brachial diastolic (mmHg)81 ± 984 ± 1185 ± 110.01
    Ankle systolic (mmHg)148 ± 17155 ± 22158 ± 260.002
    Ambulatory daytime systolic (mmHg)113 ± 12119 ± 19122 ± 150.001
    Ambulatory nighttime systolic (mmHg)104 ± 14107 ± 17104 ± 310.5
    Ankle-brachial index1.12 ± 0.111.11 ± 0.111.09 ± 0.150.2
Femoral-dorsalis pedis PWV (m/s)10.9 ± 2.011.4 ± 2.810.6 ± 2.50.8
Height (cm)167 ± 9167 ± 9169 ± 100.07
Weight (kg)81 ± 1584 ± 1690 ± 19<0.001
Waist (cm)92 ± 1295 ± 1399 ± 200.005
Fasting insulin (IU/dl)*6.3 (4.4–9.4)6.8 (4.3–8.7)7.4 (4.3–18.4)0.18
Fasting glucose (mmol/l)*5.6 (4.9–6.0)6.1 (4.9–6.8)6.6 (4.9–10.1)0.001
Cholesterol (mmol/l)5.2 ± 0.95.1 ± 1.15.1 ± 1.30.7
HDL (mmol/l)1.30 ± 0.351.25 ± 0.331.20 ± 0.350.08
Fasting triglyceride (mmol/l)*1.08 (0.78–1.40)1.15 (0.72–1.52)1.23 (0.92–1.85)0.1
Diabetes (%)3142510.012
Statin therapy (%)1215200.5
Antihypertensive therapy (%)2530400.2
Smokers (current/ex/never) (%)14/37/4924/23/5332/37/320.02
Peak response (au)47.2 (33.5–69.4)50.3 (34.9–76.2)46.9 (34.7–70.4)0.8
  • Data are means ± SD except where data are skewed, for which geometric mean and 25th and 75th percentiles are shown.

  • *

    * Log-transformed data. PWV, pulse wave velocity.