TABLE 3

Selected polymorphisms in and near the CNDP2 and CNDP1 loci

VariantGeneChangeAllele most associated with diabetic nephropathy*Odds ratio (95% CI)
D18S585′ of CNDP2CA repeat149 bp3.75 (0.45–31.26)
Rs10548323 (“DN33”)5′ of CNDP2Complex repeat208 bp1.40 (0.46–4.23)
Rs3080862 (“DN12”)5′ of CNDP2CA repeat259 bp2.53 (0.74–8.62)
Rs10464075′ of CNDP2C → TC2.33 (0.58–9.61)
Rs227781565′ of CNDP2C → TC1.86 (0.33–10.56)
Rs15598035′ of CNDP2T → AT2.94 (0.93–9.26)
Rs129659285′ of CNDP2C → TC1.57 (0.38–6.64)
DN31 (unpublished repeat 17.9 kb 3′ from rs22778156)5′ of CNDP2TA repeat341 bp1.56 (0.52–4.72)
rs7237740 (“PM”)5′ of CNDP2C → T*C1.40 (0.46–4.23)
rs3764509CNDP2 (intron)C → GC1.42 (0.43–4.76)
rs2278161 (Y126H)CNDP2A → GA1.79 (0.53–6.06)
rs2241509CNDP2 (intron)T → AT1.08 (0.35–3.26)
rs8903325′ of CNDP1T → C*T1.88 (0.43–8.26)
rs10596720 (“DN13”)CNDP1 (intron)CA repeat179 bp1.78 (0.36–8.85)
D18S880CNDP1CTG repeat6–7 Leu4.77 (1.01–22.5)
rs4892247CNDP1 (intron)T → CC1.80 (0.53–6.15)
D18S1161CNDP1 (intron)CA repeat96 bp1.16 (0.37–3.64)
rs2887CNDP1 (3′UTR)C → TC1.22 (0.22–6.76)
  • *

    * Test for association on 37 patients with diabetic nephropathy and 8 patients with no sign of diabetic nephropathy and a duration of type 2 diabetes >15 years.

  • D18S880 is a three-allele repeat encoding five, six, or seven leucine residues. It is the only variant significantly associated with diabetic nephropathy in this study. Hence, this variant was selected for further investigations.