TABLE 2

Tissue mass and insulin-mediated glucose uptake

Control subjects
Type 2 diabetes
P* obesityType 2 diabetes
NonobeseObeseNonobeseObese
Tissue mass (kg)
    Intra-abdominal fat1.5 ± 0.12.7 ± 0.21.8 ± 0.22.6 ± 0.2<0.0001NS
    Abdominal SC fat3.1 ± 0.36.7 ± 0.73.3 ± 0.25.0 ± 0.4<0.00010.02
    Whole-body SC fat14.1 ± 1.027.0 ± 1.415.6 ± 1.024.2 ± 1.3<0.0001NS
    Whole-body fat15.6 ± 1.129.7 ± 1.317.4 ± 1.026.8 ± 1.5<0.0001NS
    Skeletal muscle27.9 ± 0.732.9 ± 0.827.2 ± 0.629.2 ± 0.7<0.00010.01
Depot GU (μmol/min)
    Intra-abdominal fat33 ± 233 ± 434 ± 341 ± 5NSNS
    Whole-body SC fat193 ± 16204 ± 23183 ± 22251 ± 18NSNS
    Whole-body fat226 ± 17237 ± 26217 ± 24292 ± 22NSNS
    Skeletal muscle1,190 ± 148756 ± 1521,060 ± 159717 ± 68<0.01NS
Sum1,417 ± 147993 ± 1671,276 ± 1691,009 ± 68<0.02NS
  • Data are means ± SE.

  • *

    * P value for the effect of obesity and type 2 diabetes by two-way ANOVA.

  • Sum of glucose uptake by whole-body fat and skeletal muscle. SC, subcutaneous.