TABLE 1

Studies of the IL6−174G>C SNP in type 1 diabetes

Population (ref. no.)DesignStudy cohortSexAssociated alleleP
UK (15)C-C257 type 1 diabetic/120 controlM/FIL6-174G0.0001
UK (15)TDT53 triosM/FNoneNS
DK (8)TDT253 type 1 diabetic families*M/FIL6-174C0.04
TDT165 triosFIL6-174C0.0002
TDT168 triosMNoneNS
NL (16)TDT206 triosM/FNoneNA
  • C-C, case-control study; TDT, transmission disequilibrium testing, a family-based design.

  • *

    * 150 type 1 diabetic sibpair families and 103 type 1 diabetic trio families.