TABLE 4

In vitro IL-6 effects on islet insulin production

Ref. no.SpeciesIL-6 concentrationTime ofincubation (h)Medium insulin accumulationInsulin release (glucose concentration [mmol/l])
32Rat500–2,000 ng/ml48→ (1.67), ↓ (16.7)
5,000 ng/ml48→ (1.67), ↓ (16.7)
31Rat0.1 pmol/l to 1.0 nmol/l0.5NA→ (8)
0.1 pmol/l24NA→ (2), → (20)
10 pmol/l24NA→ (2), ↓ (20)
1 nmol/l24NA↑ (2), ↓ (20)
34Rat10 nmol/l2↓ (16.7)
47Mouse500–5,000 units/ml24–72NA↑ (NA)
37Mouse400 ng/ml24NA→ (2), → (20)
33Human125 ng/ml48→ (1.67), → (16.7)
  • NA, not available. →, unchanged; ↑, increased; ↓, decreased.