TABLE 6

IL-6 as an insulin resistance–inducing agent in skeletal muscle

SettingResult (ref. no.)Indicates IL-6 induction of insulin resistance
In vivo rodentFive-day continuous subcutaneous infusion of hIL-6 (sixfold elevation of IL-6 ∼ levels reached in obesity) does not suppress skeletal muscle insulin receptor signal transduction in mice at rest (71).No
Two-hour IL-6 challenge reduces insulin-stimulated glucose uptake in skeletal muscle in mice and is associated with defects in insulin-stimulated IRS-1–associated PI3K activity, increased levels of fatty acyl-CoA, and increased tyrosine phosphorylation of STAT3 in skeletal muscle (52).Yes
In vivo humanThree-hour IL-6 (high- and low-dose) administration does not affect muscle glucose uptake at rest (70).No
SOCS-3 expression in human skeletal muscle is not related to insulin resistance in the presence of elevated IL-6 (65).No
  • PI3K, phosphatidylinositol 3-kinase.