TABLE 4

VBM-estimated brain region volume estimates in 82 type 1 diabetic patients: correlations (Pearson) between lifetime A1C levels and percentage gray matter density

Region (cluster level)Stereotaxic coordinates (mm)
SPM99 T map
Pearson [ρ (95% CI)]
XYZTZ*P values
Left posterior cingulate (634)−20−6394.474.20< 0.001−0.49 (−0.31 to −0.64)
Left parahippocampal gyrus−12−3664.264.02< 0.001−0.49 (−0.31 to −0.64)
Left sub-gyral−23−4123.713.55< 0.001−0.49 (−0.31 to −0.64)
Right parahippocampal gyrus (331)12−3824.083.87< 0.001−0.44 (−0.24 to −0.60)
Right cuneus (545)6−9084.063.86< 0.001−0.45 (−0.25 to −0.61)
Right posterior cingulate15−62123.673.51< 0.001−0.45 (−0.25 to −0.61)
Right posterior cingulate9−68123.363.23< 0.001−0.45 (−0.25 to −0.61)
Left superior temporal gyrus (102)−59933.873.69< 0.001−0.39 (−0.18 to −0.56)
  • *

    * SPM99 T maps from the statistical comparisons were transformed into Z values, and the statistical significance was estimated using random Gaussian fields methods.

  • These areas represent connected regions on the SPM map and therefore have the same percentage of gray matter density loss.