TABLE 2

Association of SNPs detected in the genome-wide association study with evidence for replicated association in additional individuals

SNPChr.MbAlleleFrequency*Genome-wide association group
Replication group
Full population group
ORPORPHRRPAR§
rs10493685181.33C/T0.981.6 × 10−43.650.00431.93
rs6994019889.34C/A0.983.8 × 10−43.490.01891.68
rs1500415320.80A/G0.988.6 × 10−43.690.04891.63
rs18594411246.71T/C0.882.721.7 × 10−41.860.00271.170.25
rs424695321.47G/A0.882.332.6 × 10−41.630.01491.150.23
rs10520926525.36T/A0.552.172.6 × 10−51.360.03351.070.07
rs105009381122.60A/G0.202.144.6 × 10−41.650.00111.140.05
rs67284911113.54A/G0.192.841.5 × 10−51.340.01641.140.05
rs68698911113.54A/G0.193.262.7 × 10−61.270.03331.130.05
rs92900753162.50A/C0.252.477.0 × 10−51.390.01341.100.04
rs105068551280.88T/G0.026.705.7 × 10−41.790.03351.360.02
  • Data are listed in order of descending PAR.

  • *

    * Frequency of the allele listed first, which gave OR >1.

  • OR per copy of the allele listed first in the within-family analysis.

  • HRR per copy of the allele listed first.

  • §

    § Not shown for SNPs for which the number of low-risk homozygotes was too small for reliable estimation. Chr., chromosome.