TABLE 4

Strongest association results in present study for SNPs in regions identified as associated with type 2 diabetes in multiple high-density genome-wide association studies

GeneSentinel SNP*Chr.MbSNP in present studyMbAlleleFrequencyOR§PSNPs (n)
PPARGrs1801281312.38rs1051042212.51T/C0.922.310.038419
IGF2BP2rs44029603187.99rs6763887187.97G/A0.281.340.09453
CDKAL1rs10946398620.77rs775885120.65C/T0.941.820.208515
SLC30A8rs132666348118.25rs10505309118.31C/T0.142.180.033228
CDKN2Ars1081161922.12rs202579822.27G/A0.971.930.086412
HHEXrs11118751094.45rs209617794.50T/G0.791.630.04466
TCF7L2rs790314610114.75rs10509970114.91G/T0.531.300.07199
KCNJ11rs52191117.34rs219045417.49C/T0.101.270.46004
FTOrs80501361652.37rs1052130852.42T/C0.051.270.329913
  • *

    * The sentinel SNP is that with the strongest association with diabetes across multiple genome-wide association studies (refs. 4750).

  • The SNP with the smallest P value within a 200-kb window on either side of the sentinel SNP is reported.

  • Frequency of the allele listed first, which gave OR >1.

  • §

    § OR in the within-family analysis per copy of the allele listed first.

  • SNPs from the present study in the 400-kb window surrounding the sentinal SNP. Chr., chromosome.