TABLE 3

Association between SNPs in TCF7L2 and obesity and diabetes-related phenotypes among nondiabetic Pima Indians

rs7903146
Prs7895340
Prs7895307
P
CCCTTTGGGAAAAAAGGG
Nondiabetic
Male/females (n)171/13430/300/2189/13642/370/2114/6691/8026/26
Age (years)26.6 ± 6.0026.1 ± 6.1628.2 ± 7.0026.6 ± 6.0126.4 ± 6.1628.2 ± 7.0026.8 ± 6.2626.9 ± 6.0425.5 ± 5.93
Percent body fat*33.3 ± 8.5733.8 ± 8.3229.3 ± 7.920.2433.1 ± 8.6033.6 ± 8.3029.3 ± 7.920.2733.3 ± 8.5433.1 ± 8.7333.1 ± 8.230.03
BMI (kg/m2)*34.3 ± 7.3034.3 ± 7.8926.1 ± 9.830.5734.2 ± 7.3334.4 ± 8.3426.1 ± 9.830.5334.9 ± 7.9134.0 ± 7.4232.5 ± 6.220.009
Fasting plasma glucose (mmol/l)*§5.01 ± 0.554.96 ± 0.575.36 ± 0.510.744.99 ± 0.554.99 ± 0.555.36 ± 0.510.884.98 ± 0.535.03 ± 0.574.97 ± 0.540.87
2-h plasma glucose (mmol/l)*§6.79 ± 1.697.13 ± 1.608.220.086.77 ± 1.697.19 ± 1.648.220.036.72 ± 1.667.05 ± 1.756.70 ± 1.560.82
Log10 fasting plasma insulin (μU/ml)*§1.57 ± 0.211.58 ± 0.221.47 ± 0.380.541.56 ± 0.211.56 ± 0.221.47 ± 0.380.81.57 ± 0.211.55 ± 0.211.58 ± 0.210.55
Log10 2-h plasma insulin (μU/ml)*§2.20 ± 0.342.21 ± 0.362.51 ± 0.070.582.20 ± 0.342.18 ± 0.352.51 ± 0.070.942.22 ± 0.342.18 ± 0.342.18 ± 0.320.28
Log10 glucose disposal (mg · kg EMBS−1 · min−1)*§0.54 ± 0.110.54 ± 0.120.57 ± 0.050.940.54 ± 0.120.54 ± 0.110.57 ± 0.050.80.54 ± 0.120.54 ± 0.110.56 ± 0.120.54
Normal glucose tolerant
Male/female (n)138/8624/140/1153/9032/160/188/4577/4421/15
Log10 AIR (μU/ml)*§2.36 ± 0.282.32 ± 0.272.010.062.35 ± 0.272.33 ± 0.272.010.072.33 ± 0.302.33 ± 0.252.45 ± 0.260.02
Log10 30-min plasma insulin (μU/ml)*§2.35 ± 0.272.34 ± 0.242.100.152.35 ± 0.262.33 ± 0.232.100.092.35 ± 0.262.32 ± 0.232.42 ± 0.300.11
  • Data are raw means ± SD for each trait grouped by genotype. P values were calculated for the adjusted means. Covariates for adjustments are listed as:

  • *

    * age,

  • sex,

  • family membership,

  • §

    § percentage of body fat,

  • glucose disposal rate, and

  • ¶30 min glucose levels. Significant P values (<0.05) are shown in boldface. Analysis of early insulin secretion (AIR and 30-min plasma insulin during an OGTT) is restricted to subjects with normal glucose tolerance. EMBS, estimated metabolic body size; IVGTT, intravenous glucose tolerance test.