TABLE 4

Alcohol consumption, ADH1C polymorphism, and risk of type 2 diabetes among 640 case and 1,000 control subjects from the NHS and 383 case and 382 control subjects from the HPFS

ADH1C*1/*1ADH1C*1/*2ADH1C*2/*2Ptrend
Women
    0 g/day
Cases/controls139/132144/19240/53
Multivariate adjusted1.00.76 (0.53–1.09)0.78 (0.46–1.33)0.20
    0–4.9 g/day
Cases/controls75/10995/14044/71
Multivariate adjusted0.60 (0.39–0.91)0.74 (0.50–1.10)0.62 (0.38–1.02)0.76
    ≥5 g/day
Cases/controls24/10649/14130/56
Multivariate adjusted0.24 (0.14–0.43)0.41 (0.26–0.66)0.60 (0.34–1.07)0.009
Men
    0 g/day
Cases/controls34/3246/4819/18
Multivariate adjusted1.00.64 (0.31–1.30)0.96 (0.40–2.35)0.72
    0–9.9 g/day
Cases/controls65/5068/6923/15
Multivariate adjusted†1.16 (0.58–2.30)0.86 (0.44–1.67)1.22 (0.49–3.04)0.63
    ≥10 g/day
Cases/controls39/5067/7522/25
Multivariate adjusted0.73 (0.35–1.54)0.96 (0.48–1.91)0.93 (0.39–2.25)0.29
  • Adjusted for BMI, physical activity, smoking, family history of diabetes, postmenopausal hormone replacement therapy, energy intake, and energy-adjusted intake of saturated fat, trans fatty acids, polyunsaturated fat, dietary fiber, glycemic load, and coffee consumption.