TABLE 1

Clinical and laboratory characteristics

LeanObeseType 2 diabetes
n7814
Sex (M/F)4/33/55/9
Age (years)45 ± 244 ± 352 ± 3
BMI (kg/m2)25.3 ± 0.730.5 ± 0.6*31.8 ± 1.2*
Fasting glucose (mmol/l)5.4 ± 0.25.6 ± 0.17.8 ± 0.6*
Glucose AUC during OGTT (mg/dl · 2 h)120 ± 11121 ± 8230 ± 18*
Fasting insulin (pmol/l)19 ± 492 ± 16*86 ± 16*
HOMA-IR0.6 ± 0.12.0 ± 0.3*2.1 ± 0.4*
Fasting FFAs (μmol/l)351 ± 37479 ± 59*750 ± 29*
FFA AUC during OGTT (μmol/l · 2 h)22.8 ± 1.131.3 ± 3.3*55.9 ± 3.7*
TNF-α (pg/ml)1.26 ± 0.101.63 ± 0.302.13 ± 0.32*
IL-6 (pg/ml)1.17 ± 0.151.91 ± 0.402.42 ± 0.33*
  • Data are means ± SE.

  • *

    * P < 0.05 vs. lean;

  • P < 0.05 vs. obese.