TABLE 2

Effect of central and global CB1 blockade on plasma glucose, insulin, nonesterified fatty acid, and corticosterone levels in DIO rats

Central CB1 blockade
Global CB1 blockade
Vehicle (ad libitum fed)CB1 antagonistVehical (pair fed)Vehicle (ad libitum fed)CB1 antagonistVehical (pair fed)
Glucose (mmol/l)5.35 ± 0.773.78 ± 0.124.11 ± 0.244.07 ± 0.625.32 ± 0.594.53 ± 0.38
Insulin (ng/ml)1.67 ± 0.350.58 ± 0.121.04 ± 0.172.25 ± 0.361.38 ± 0.233.45 ± 0.73
Nonesterified fatty acids (mmol/l)0.87 ± 0.120.66 ± 0.130.98 ± 0.171.78 ± 0.490.95 ± 0.140.94 ± 0.1
Corticosterone (ng/ml)59.84 ± 9.2859.77 ± 7.2663.91 ± 7.1438.67 ± 4.6573.35 ± 10.1*75.08 ± 9.62*
  • Data are means ± SE of five to seven animals per group. Rats were intracerebroventricularly infused (5 μg/rat per day) or peripherally injected (10 mg · kg−1 · day−1) with either CB1 antagonist or vehicle (controls) for 6 days. Vehicle pair-fed animals were restricted to the same amount of food as that consumed by CB1 antagonist–infused rats.

  • *

    * P < 0.05 vs. controls.