TABLE 1

Single-marker multivariate results with q value <0.5 in DCCT/EDIC probands for severe nephropathy and persistent microalbuminuria

Gene symbolSNPAllele
χ12P valueHR (95% CI)q value
MajorMinor (%)
Severe nephropathy
SOD1rs17880135AC (5.7)16.245.6 × 10−52.62 (1.64–4.18)0.07
CASP3rs2705897CA (26.4)9.871.7 × 10−31.62 (1.20–2.17)0.46
TRPC6rs3824935GA (9.9)9.771.8 × 10−32.00 (1.29–3.08)0.46
TGFBR2rs2276768GA (10.8)9.522.0 × 10−30.40 (0.22–0.71)0.46
HPSErs4693614AG (23.2)9.442.1 × 10−31.61 (1.19–2.19)0.46
CYP11B2rs7844961GA (8.4)8.932.8 × 10−31.89 (1.25–2.88)0.46
COX5Ars8042694AG (28.8)8.922.8 × 10−31.59 (1.17–2.16)0.46
NPHS1rs3814995GA (32.5)8.583.4 × 10−30.61 (0.44–0.85)0.46
ATP5G3rs10497435AG (4.3)8.573.4 × 10−32.39 (1.33–4.29)0.46
FLT4rs307806GA (14.9)8.074.5 × 10−31.66 (1.17–2.37)0.46
FLT4rs2279622GA (6.4)8.014.7 × 10−31.95 (1.23–3.10)0.46
UQCRC1rs11715496CA (2.0)7.885.0 × 10−32.63 (1.34–5.16)0.46
BDKRB2rs4900312GA (20.0)7.815.2 × 10−30.57 (0.39–0.85)0.46
LIPCrs1968685CG (48.2)7.825.2 × 10−30.65 (0.47–0.88)0.46
PARP1rs2027440AG (15.8)7.506.2 × 10−31.60 (1.14–2.24)0.48
PARP1rs3219065AG (15.8)7.506.2 × 10−31.60 (1.14–2.24)0.48
Persistent microalbuminuria
SOD1rs17880135AC (5.7)11.646.5 × 10−41.82 (1.29–2.57)0.48
PON1rs1157745CA (27.6)10.561.2 × 10−30.68 (0.54–0.86)0.48
PON1rs3917532AT (27.6)10.561.2 × 10−30.68 (0.54–0.86)0.48
AKR1B1rs2259458CA (30.7)10.191.4 × 10−31.36 (1.13–1.64)0.48
FLT4rs307806GA (14.9)6.471.1 × 10−21.37 (1.08–1.75)0.66
FLT4rs10516142GA (3.0)6.291.2 × 10−21.85 (1.15–3.03)0.66
  • Sample size for the analysis of persistent microalbuminuria, 1,296; sample size for the analysis of severe nephropathy, 1,362. No SNPs had q values <0.5 for any of the retinal outcomes. The HR is specified for each minor allele using the common homozygote genotype as the baseline. Results for two FLT4 SNPs are included for the persistent microalbuminuria results because SNPs in FLT4 also show evidence for association with severe nephropathy. P values are based on the Wald test.