TABLE 3

Single-marker multivariate results for time to renal outcomes for SNPs in SOD1 and SFRS15 in DCCT/EDIC probands

SNPAllele
Persistent microalbuminuria
Severe nephropathy
MajorMinor (%)χ12P valueHR (95% CI)q valueχ12P valueHR (95% CI)q value
rs9974610AG (17.6)16.474.9 × 10−51.59 (1.27–1.96)NA2.000.161.28 (0.91–1.82)NA
rs202446CA (14.3)17.153.5 × 10−51.64 (1.29–2.08)NA7.640.00571.65 (1.16–2.35)NA
rs17881180GA (5.2)15.189.8 × 10−52.04 (1.43–2.92)NA20.55.8 × 10−63.03 (1.88–4.89)NA
rs17884536CA (3.8)0.370.551.15 (0.73–1.81)0.960.930.340.67 (0.29–1.51)0.88
rs17880998GA (10.4)0.920.341.15 (0.86–1.54)0.960.110.751.07 (0.68–1.72)0.88
rs17878806AT (45.5)0.500.480.93 (0.78–1.14)NA0.920.340.86 (0.65–1.15)NA
rs17880753TG (3.7)0.800.371.23 (0.79–1.91)NA0.480.490.75 (0.33–1.68)NA
rs17880196GA (32)1.690.190.88 (0.72–1.06)0.961.420.230.83 (0.61–1.12)0.88
rs17880135AC (5.7)11.646.4 × 10−41.82 (1.29–2.57)0.4816.25.6 × 10−52.62 (1.64–4.18)0.07
rs17881203AG (1.5)1.730.191.56 (0.80–3.00)NA4.190.0402.38 (1.04–5.26)NA
rs204732CT (15.4)16.484.9 × 10−51.59 (1.28–2.00)NA3.620.0571.39 (0.99–1.96)NA
  • NA, not calculated because that SNP was not genotyped on the initial Illumina assay. According to dbSNP build 125, the following are identical: rs17884536 = rs6650814; rs17880998 = rs4998557; rs17880196 = rs1041740; rs17880753 = rs2234694; rs17878806 = rs9967983. The HR is specified for each minor allele using the common homozygote genotype as the baseline. The P value is from the Wald test. Sample sizes for this analysis are provided in online appendixes 5 and 15.