TABLE 4

Multistate analyses of SOD1 SNPs

SNPFrom normal to PM
From PM to SN
From normal to PM vs. from PM to SN P valueFrom normal to SN
χ2P valueHR (95% CI)χ2P valueHR (95% CI)χ2P valueHR (95% CI)
rs997461016.484.9 × 10−51.56 (1.25–1.92)0.370.551.11 (0.79–1.54)0.0871.470.231.22 (0.88–1.69)
rs20244616.893.9 × 10−51.61 (1.28–2.03)2.490.111.33 (0.93–1.89)0.364.470.0351.44 (1.03–2.03)
rs1788118013.702.1 × 10−41.93 (1.36–2.73)6.600.011.85 (1.16–2.95)0.8912.633.8 × 10−42.25 (1.44–3.52)
rs178845360.150.71.09 (0.70–1.69)3.100.0780.47 (0.21–1.09)0.0823.520.0610.45 (0.20–1.04)
rs178809980.890.351.15 (0.87–1.51)0.040.840.95 (0.59–1.54)0.510.530.460.84 (0.53–1.33)
rs178788060.460.50.93 (0.78–1.14)1.060.30.85 (0.64–1.15)0.614.080.0430.74 (0.55–0.99)
rs178807530.420.521.15 (0.75–1.77)2.530.110.51 (0.23–1.17)0.0872.220.140.54 (0.24–1.21)
rs178801961.720.190.88 (0.72–1.06)1.010.320.85 (0.62–1.16)0.863.370.0660.75 (0.55–1.02)
rs1788013510.380.00131.74 (1.24–2.43)4.590.0321.65 (1.04–2.60)0.8610.510.00122.07 (1.33–3.22)
rs178812031.680.21.54 (0.80–2.94)0.330.571.30 (0.53–3.12)0.761.090.31.56 (0.68–3.58)
rs20473216.345.3 × 10−51.56 (1.27–1.96)0.060.811.04 (0.75–1.45)0.0440.900.341.16 (0.85–1.61)
  • For details, see legend to Table 2 and online appendix text. Note that this model includes all the covariates in the multivariate model (see research design and methods and online appendix 2) except for the updated indicator for hypertension. P values are based on the Wald test. PM, persistent microalbuminuria; SN, severe nephropathy.