TABLE 5

Univariate association of SOD1 SNPs in other studies

StudySNP GenotypeCase subjects
Control subjects
Cochran-Armitage POdds ratio (95% CI)
m/mm/MM/Mm/mm/MM/M
GoKinDRs178001351 (0.1%)98 (11.9%)727 (88.0%)2 (0.2%)98 (10.9%)802 (88.9%)0.611.08 (0.81–1.44)
rs178811801 (0.1%)93 (11.2%)737 (88.7%)1 (0.1%)94 (10.3%)812 (89.5%)0.581.09 (0.81–1.46)
rs20244614 (1.7%)187 (22.5%)629 (75.8%)17 (1.8%)221 (24.3%)670 (73.8%)0.350.91 (0.75–1.11)
rs20473216 (1.9%)211 (25.5%)599 (72.5%)28 (3.1%)221 (24.4%)655 (72.5%)0.620.95 (0.79–1.15)
Irelandrs178801351 (0.4%)38 (14.2%)228 (85.4%)2 (0.5%)53 (12.0%)386 (87.5%)0.461.18 (0.77–1.79)
Pittsburgh Epidemiology of Diabetes Complications (cross-sectional analysis)
    Microalbuminuriars178001351 (1.0%)9 (9.2%)88 (89.8%)0 (0.0%)29 (12.0%)213 (88.0%)0.850.94 (0.46–1.89 )
    Microalbuminuriars178011800 (0.0%)10 (10.1%)89 (89.9%)0 (0.0%)26 (10.6%)219 (89.4%)0.890.95 (0.44–2.04)
    Severe nephropathyrs178001352 (1.8%)13 (11.8%)95 (86.3%)0 (0.0%)29 (12.0%)213 (88.0%)0.391.31 (0.71–2.42)
    Severe nephropathyrs178011800 (0.0%)13 (11.8%)97 (88.2%)0 (0.0%)26 (10.6%)219 (89.4%)0.741.13 (0.56–2.29)
    Meta-analysis*rs178801351.13 (0.69–1.84)
Cross-sectional analysis of DCCT/EDIC
    PMrs178801353 (1.0%)39 (12.5%)271 (86.6%)5 (0.5%)90 (9.2%)879 (90.3%)0.0591.40 (0.98–2.00)
    PMrs20244613 (4.3%)79 (26.0%)212 (69.7%)14 (1.5%)231 (24.5%)697 (74.0%)0.0331.31 (1.02–1.68)
    SNrs178801352 (1.7%)20 (17.4%)93 (80.9%)5 (0.5%)90 (9.2%)879 (90.3%)0.00142.05 (1.30–3.24)
    SNrs2024467 (6.3%)29 (26.1%)75 (67.6%)14 (1.5%)231 (24.5%)697 (74.0%)0.0231.51 (1.05–2.17)
  • The inclusion/exclusion criteria for case and control subjects for each study is provided in the online appendix text. The association of SNP genotypes with diabetic nephropathy was performed using the Cochran-Armitage exact trend test, and association was estimated by odds ratios using logistic regression with additive coding of the number of minor alleles as a covariate. Meta-analysis was conducted by linear regression of the log odds ratio estimates on study indicators, with inverse variance weighting, in fixed and random effects models. M, major allele; m, minor allele; PM, persistent microalbuminuria; SN, severe nephropathy.

  • *

    * Case definition from each study differed. †Overt nephropathy and ESRD were combined from Pittsburgh Epidemiology of Diabetes Complications.