TABLE 2

Metabolic characteristics of the study cohort across visceral tertiles, adjusted for age, sex, and race/ethnicity

Tertile 1: 0.027–0.089Tertile 2: 0.089–0.12Tertile 3: 0.122–0.224P for trend
UnadjustedAdjusted
n394039
Fasting glucose (mg/dl)*93.0 (90.0–95.9)92.5 (89.7–95.3)92.8 (89.9–95.8)0.690.33
2-h glucose (mg/dl)*115.7 (108.4–123.0)123.1 (116.3–129.9)129.7 (122.5–137.0)0.0060.003
Fasting insulin (μU/ml)29.4 (25.1–34.4)34.2 (29.5–40.0)41.3 (35.3–48.2)0.02<0.001
Proinsulin (pmol/l)19.1 (15.2–24.2)24.1 (19.4–29.8)27.5 (21.8–34.7)0.010.01
Fasting C-peptide (pmol/l)1,034 (905–1,181)1,227 (1,085–1,388)1,401 (1,229–1,598)0.0010.002
Insulin sensitivity (Matsuda index)1.87 (1.53–2.28)1.35 (1.13–1.61)1.04 (0.87–1.26)<0.001<0.001
Homeostasis model assesment6.7 (5.7–8.0)7.8 (6.6–9.1)9.4 (8.0–11.1)0.02<0.001
Fasting FFA (μmol/l)*463.8 (413.3–514.2)508.2 (460.4–555.9)545.7 (493.3–598.1)0.140.22
Triglycerides (mg/dl)71.6 (60.4–84.8)88.4 (75.6–103.4)103.9 (87.9–122.8)<0.001<0.001
HDL (mg/dl)45.4 (42.5–48.4)44.1 (41.4–46.9)41.8 (38.8–44.7)<0.0010.03
Adiponectin (μg/ml)8.1 (6.9–9.5)6.9 (5.9–8.0)6.2 (5.3–7.3)0.120.08
High–molecular-weight adiponectin (μg/ml)1.67 (1.25–2.24)1.20 (0.92–1.57)1.21 (0.91–1.61)0.280.11
Leptin (ng/ml)40.6 (35.6–45.6)33.8 (29.3–38.3)27.9 (23.1–32.7)<0.0010.003
CRP (mg/dl)1.2 (0.8–1.8)1.8 (1.3–2.6)1.5 (1.0–2.2)0.790.40
IL-6 (pg/ml)1.4 (1.1–1.8)1.9 (1.6–2.4)1.7 (1.4–2.1)0.620.16
  • Data are n (%),

  • *

    * means (95% CI), and

  • geometic means (95% CI). Data in bold indicate significance.