TABLE 1

In vitro inhibition of human and rat SGLT2 and SGLT1 by dapagliflozin and phlorizin

Human SGLT2Human SGLT1Rat SGLT2Rat SGLT1
Dapagliflozin1.12 ± 0.065 (n = 18)1,391 ± 7 (n = 16)3.0 ± 0.5 (n = 5)620 ± 70 (n = 6)
Phlorizin35.6 ± 4.2 (n = 11)330 ± 50 (n = 10)75 ± 8 (n = 4)302 ± 30 (n = 4)
  • Data are mean EC50 ± SE (nmol/l).