TABLE 1

Physical and metabolic parameters of high-fat–fed BNP-Tg mice

Wild typeBNP-Tg
Body weight (g)
    18 weeks old43.0 ± 0.938.9 ± 0.9*
Glucose (mg/dl)
    Ad libitum feeding230.2 ± 10.5196.7 ± 16.5
    24-h fasting135.9 ± 7.9104.0 ± 10.2
Insulin (ng/dl)
    Ad libitum feeding9.87 ± 1.95.25 ± 1.1
    24-h fasting1.05 ± 0.20.86 ± 0.1
Triglyceride (mg/dl)
    Ad libitum feeding131.9 ± 13.2126.7 ± 15.6
    24-h fasting90.9 ± 7.992.6 ± 8.8
Fatty acid (mEq/l)
    Ad libitum feeding1.28 ± 0.101.08 ± 0.09
    24-h fasting1.70 ± 0.171.75 ± 0.21
Epinephrine (ng/day)
    Urinary excretion26.5 ± 2.928.0 ± 4.2
Norepinephrine (ng/day)
    Urinary excretion358.0 ± 15.1349.0 ± 52.8
  • *P < 0.01,

  • P < 0.05, compared with wild type.